Gastrointestinal Tract News and Research

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Chi-Med announces initiation of Phase III sulfatinib registration trial in patients with NETs in China

Hutchison China MediTech Limited today announces that Hutchison MediPharma Limited, its drug R&D subsidiary, has initiated SANET-ep, a Phase III sulfatinib (HMPL-012) registration trial in China in patients with extra-pancreatic neuroendocrine tumors ("NETs"), which are all non-pancreatic NETs, including, for example, NETs originating in the lymph, lung and across the gastrointestinal tract.

18 Dec 2015

Stem cell therapy not significantly better than conventional treatment for Crohn's disease

A clinical trial to test the effectiveness of a stem cell therapy among adults with difficult to treat Crohn's disease has found it is not significantly better than conventional treatment in producing sustained disease remission after one year.

18 Dec 2015

Hematopoietic stem cell transplantation does not provide improvement for patients with Crohn disease

Among adults with difficult to treat Crohn disease not amenable to surgery, hematopoietic stem cell transplantation, compared with conventional therapy, did not result in significant improvement in sustained disease remission at l year and was associated with significant toxicity, according to a study in the December 15 issue of JAMA.

16 Dec 2015

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Lexicon Pharmaceuticals, Inc. announced today that top-line data from its TELECAST Phase 3 study showed results of telotristat etiprate in treating carcinoid syndrome in cancer patients with metastatic neuroendocrine tumors consistent with the clinical benefit observed in its pivotal TELESTAR study.

1 Dec 2015

Genetic information of patients with IBD could provide road map for more effective treatments

Genetic variation in patients with inflammatory bowel disease (IBD) appears to play a major role in determining how sick they will become and could provide a road map for more effective treatments.

1 Dec 2015

Six-month markers predict long-term cGVHD outcomes

Researchers have identified measures early in the course of chronic graft-versus-host disease that predict long-term prognosis in haematopoietic cell transplantation recipients.

27 Nov 2015

Findings could offer doctors new method to diagnose pancreatic cancer earlier in patients

By collecting samples from the portal vein--which carries blood from the gastrointestinal tract, including from the pancreas, to the liver--physicians can learn far more about a patient's pancreatic cancer than by relying on peripheral blood from a more easily accessed vein in the arm.

23 Nov 2015

Scientists show how absence of microbiota has remarkable effect against obesity

In the past few years, research on gut microbiota (that is, all microorganisms, mainly bacteria, inhabiting our gut) has started to unravel its tremendous role in our body, and how it symbiotically affects the functioning of our organs. In particular, microbiota has also an impact on the way calories are absorbed and how fat cells develop.

17 Nov 2015

Improved gene therapy treatment shows promise in mice with cystic fibrosis

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular Virology and Gene Therapy at KU Leuven, Belgium.

17 Nov 2015

EU-funded research project aims to reduce oxidation in processed meat products

An EU-funded research project is to make sausages, patties and other meat products healthier in the future. Researchers at Lund University in Sweden, the Swedish University of Agricultural Sciences (SLU) and four other European research institutions have launched a joint project to reduce the risk of colon cancer - the most common cancer of the gastrointestinal tract in Sweden.

13 Nov 2015

Sausages With Antioxidants From Berries To Prevent Cancer

An EU-funded research project is to make sausages, patties and other meat products healthier in the future.

11 Nov 2015

Gastric reduction surgery can significantly increase patient's risk of developing allergy

Amongst other things, operations to reduce the size of the stomach can significantly increase the patient's risk of developing an allergy. This is the conclusion of a study conducted by the Medical University of Vienna.

4 Nov 2015

Unique funding opportunity seeks countermeasures to protect healthy tissue from radiation exposure

Small U.S.-based companies developing countermeasures to protect healthy tissue from the effects of radiation exposures may be eligible for a unique funding opportunity offered through the National Space Biomedical Research Institute. NSBRI's Industry Forum is soliciting applications for its Space Medical and Related Technologies Commercialization Assistance Program (SMARTCAP).

31 Oct 2015

Scientists call for coordinated effort to drive cutting edge microbiome research

A consortium of 48 scientists from 50 institutions in the United States - including Pamela Silver, Ph.D., a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard University - are calling for a Unified Microbiome Initiative that would span national cross-institutional and cross-governmental agency support.

29 Oct 2015

Oral formulation of insulin shows promise in management of blood glucose in diabetic rats

An intestinal patch device containing insulin that can be swallowed in the form of a capsule, in development by researchers at University of California Santa Barbara, has demonstrated efficacy of blood glucose management in diabetic rats. This work is being presented Oct. 27 at the 2015 American Association of Pharmaceutical Scientists Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Orlando, Fla. Oct. 25-29.

28 Oct 2015

Study links antibiotic use during childhood to weight gain

Children who take antibiotics during the course of their childhood gain weight more quickly than those who do not, according to a study published in the International Journal of Obesity.

22 Oct 2015

Children who receive repeated antibiotics gain weight faster over time

Kids who receive antibiotics throughout the course of their childhoods gain weight significantly faster than those who do not, according to new Johns Hopkins Bloomberg School of Public Health research.

22 Oct 2015

Veltassa (patiromer for oral suspension) gets FDA approval for treatment of hyperkalemia

The U.S. Food and Drug Administration today approved Veltassa (patiromer for oral suspension) to treat hyperkalemia, a serious condition in which the amount of potassium in the blood is too high.

22 Oct 2015

Lexicon's telotristat etiprate improves social and physical function, emotional well-being in cancer patients

Lexicon Pharmaceuticals, Inc.'s telotristat etiprate, the first oral therapy in development for the treatment of carcinoid syndrome (CS), was associated with patient-reported improvements in social and physical function and emotional well-being according to new exit interview data from the Phase 3 TELESTAR study presented at the 2015 Neuroendocrine Tumor Society Annual Symposium in Austin, Texas.

19 Oct 2015

Study could lead to better understanding of metabolic processes behind type 2 diabetes

Scientists in Sweden have discovered that human intestinal flora regulates the levels of the body's main antioxidant, glutathione, which fights a host of diseases. The findings could lead to new probiotic-delivering foods, and a better understanding of the metabolic processes behind diseases such as type 2 diabetes.

19 Oct 2015

Gastrointestinal Tract News and Research

Chi-Med announces initiation of Phase III sulfatinib registration trial in patients with NETs in China

Stem cell therapy not significantly better than conventional treatment for Crohn's disease

Hematopoietic stem cell transplantation does not provide improvement for patients with Crohn disease

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Genetic information of patients with IBD could provide road map for more effective treatments

Six-month markers predict long-term cGVHD outcomes

Findings could offer doctors new method to diagnose pancreatic cancer earlier in patients

Scientists show how absence of microbiota has remarkable effect against obesity

Improved gene therapy treatment shows promise in mice with cystic fibrosis

EU-funded research project aims to reduce oxidation in processed meat products

Sausages With Antioxidants From Berries To Prevent Cancer

Gastric reduction surgery can significantly increase patient's risk of developing allergy

Unique funding opportunity seeks countermeasures to protect healthy tissue from radiation exposure

Scientists call for coordinated effort to drive cutting edge microbiome research

Oral formulation of insulin shows promise in management of blood glucose in diabetic rats

Study links antibiotic use during childhood to weight gain

Children who receive repeated antibiotics gain weight faster over time

Veltassa (patiromer for oral suspension) gets FDA approval for treatment of hyperkalemia

Lexicon's telotristat etiprate improves social and physical function, emotional well-being in cancer patients

Study could lead to better understanding of metabolic processes behind type 2 diabetes

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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