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Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

Study shows expression of viral proteases may be used to quantitate SARS-CoV-2 infected cells

A new study describes a new method to quantify SARS-CoV-2 infection, which is much simpler and faster compared to existing methods.

14 Feb 2022

Researchers identify autoantibody targets in COVID-19 patients

In a new study, researchers have been investigating auto-immune responses to natural human antigens in COVID-19 patients.

14 Feb 2022

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

Super-resolution imaging of the human coronavirus genome during infection

Using high-throughput confocal super-resolution microscopy, scientists visualize the genomic material of the human coronavirus HCoV-229E.

9 Feb 2022

Novel, rapid and efficient assay for SARS-CoV-2 neutralizing antibodies

Researchers validate a quick, highly efficient, and automated assay to detect neutralizing antibodies against SARS-CoV-2.

7 Feb 2022

Evolutionary history of ACE2 binding across a diverse range of sarbecoviruses and ACE2 orthologs

Researchers have been investigating sarbecovirus lineages and the ability of those lineages to evolve the ability to bind ACE2.

7 Feb 2022

Neutralizing antibodies against SARS-CoV-2 variants induced by homologous and heterologous COVID-19 booster vaccination

In this study, scientists focused on identifying tentative cut-offs for large-scale evaluations of immune protection against SARS-CoV-2 and its variants.

3 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

Researchers discover why patients suffering with hypertension also have diabetes

The long-standing enigma of why so many patients suffering with high blood pressure (known as hypertension) also have diabetes (high blood sugar) has finally been cracked by an international team led by the universities of Bristol, UK, and Auckland, New Zealand.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Ingenza collaborates with Johnson Matthey for efficient industrial enzyme synthesis

Biotechnology company Ingenza is excited to report the successful conclusion to its recent six-month project with Johnson Matthey.

1 Feb 2022

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Researchers study the interaction between immunity to endemic coronaviruses and SARS-CoV-2.

30 Jan 2022

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Researchers demonstrate how cytotoxic T-lymphocytes (CTLs) with specificity for SARS-CoV-2 eliminate multiple infected targets.

30 Jan 2022

Alpaca-derived antibody fragment disrupts interaction between SARS-CoV-2 spike protein and human ACE2

Researchers have been investigating the potential for using nanobodies – special immune particles from llamas and alpacas – against the disease.

24 Jan 2022

Researchers are in the race to beat Omicron

David Veesler and his lab members aren't getting much sleep these days. In the final weeks of 2021, he and his team worked around the clock to post four coronavirus papers on the preprint server bioRxiv.

24 Jan 2022

Novel antibody that targets the N-terminal domain of SARS-CoV-2 identified

A new study discusses the targeted discovery of NTD-reactive antibodies from an individual who had recovered from SARS-CoV-2 infection.

19 Jan 2022

SARS-CoV-2 vaccination of convalescents suggested to boost neutralization capacity against variants

A new study assessed the neutralization capacity of sera from convalescents—some even vaccinated—against the Wuhan (D614G), Delta and Omicron variants of SARS-CoV-2.

19 Jan 2022

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

A new paper discusses the appearance of quasi-species in a single host with prolonged infection, with different rates of infectivity and sensitivity to neutralization by antibodies elicited by the Pfizer vaccine or those present in convalescent plasma.

17 Jan 2022

Study shows Omicron less severe than Delta among COVID-19 hospitalized patients

New research posted to the medRxiv* preprint server suggests the Omicron variant produces less severe COVID-19 symptoms than earlier severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

16 Jan 2022

High Throughput News and Research

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Study shows expression of viral proteases may be used to quantitate SARS-CoV-2 infected cells

Researchers identify autoantibody targets in COVID-19 patients

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Super-resolution imaging of the human coronavirus genome during infection

Novel, rapid and efficient assay for SARS-CoV-2 neutralizing antibodies

Evolutionary history of ACE2 binding across a diverse range of sarbecoviruses and ACE2 orthologs

Neutralizing antibodies against SARS-CoV-2 variants induced by homologous and heterologous COVID-19 booster vaccination

Nanomedicine can be improved with proper and more predictive in vitro assays

Researchers discover why patients suffering with hypertension also have diabetes

Mutational analysis of SARS-CoV-2 main protease

Ingenza collaborates with Johnson Matthey for efficient industrial enzyme synthesis

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Alpaca-derived antibody fragment disrupts interaction between SARS-CoV-2 spike protein and human ACE2

Researchers are in the race to beat Omicron

Novel antibody that targets the N-terminal domain of SARS-CoV-2 identified

SARS-CoV-2 vaccination of convalescents suggested to boost neutralization capacity against variants

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

Study shows Omicron less severe than Delta among COVID-19 hospitalized patients

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