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Ohio State researchers enter federal cooperative agreement to develop radiation biodosimetry solutions

Researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have entered a federal cooperative agreement, valued up to $9.42 million, that will help them further develop Ohio State's biodosimetry technology to discover noninvasive biomarkers for radiation exposure – work that will have national security applications.

2 Nov 2022

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

Researchers demonstrated how interferon-stimulated gene 15 (ISG15) is involved in the Vaccinia virus (VACV) dissemination.

1 Nov 2022

Scientists reveal anti-inflammatory molecules that play an important role in aging

Aging involves complicated plot twists and a large cast of characters: inflammation, stress, metabolism changes, and many others. Now, a team of Salk Institute and UC San Diego scientists reveal another factor implicated in the aging process - a class of lipids called SGDGs (3-sulfogalactosyl diacylglycerols) that decline in the brain with age and may have anti-inflammatory effects.

31 Oct 2022

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Researchers analyzed the phenotypes of the SARS-CoV-2 variants of concern (VOCs), the molecular responses to infections from these VOCs, and the evolving virus-host interactions using a comparative genomic and proteomic approach.

26 Oct 2022

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

In a new study, researchers performed an in vitro analysis to isolate ultralong bovine heavy chains that showed binding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses (CoVs).

24 Oct 2022

The Emerging Field of Gene Therapy with Adeno-Associated Viruses

In this interview, Arnaud Delobel, the R&D and Innovation Director at Quality Assistance talks to NewsMed-LS about the emerging field of gene therapy with adeno-associated viruses (AAV).

From Waters | Wyatt Technology 18 Oct 2022

Do phthalates in face masks pose health hazards with increased usage during the COVID-19 pandemic?

In a new study, researchers investigated the presence of phthalic acid esters (PAEs) or phthalates in commercially available face masks to assess the health risks associated with the increased use of face masks during the coronavirus disease 2019 (COVID-19) pandemic.

17 Oct 2022

Investigating plasma signatures of platelet-derived proteins in acute pulmonary embolism

In a new study, researchers determined plasma signatures of proteins related to or derived from platelets in acute isolated pulmonary embolism (iPE) and deep vein thrombosis-associated PE (DVT-PE), compared to isolated DVT (iDVT).

17 Oct 2022

Mouse model reveals how RNA splicing defects contribute to neurodegeneration in Alzheimer's disease

Researchers have puzzled over the neurodegenerative disorder Alzheimer's disease for decades, but treatments to stop or reverse the disease's effects on the brain have remained elusive.

13 Oct 2022

Metabolite discovery offers a potential way to address metabolic conditions

"Metabolism" describes the body's chemical changes that create the necessary materials for growth and overall health. Metabolites are the substances made and used during these metabolic processes - or, as a new discovery out of Scripps Research and its drug development arm, Calibr, indicates, they could also be potent molecules for treating severe diseases.

13 Oct 2022

Key biophysical attributes of a self-amplifying viral RNA vaccine developed for SARS-CoV-2

Researchers used various analytical characterization techniques to determine the biophysical attributes of the Imperial College London self-amplifying viral RNA vaccine (IMP-1) developed for SARS-CoV-2.

5 Oct 2022

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

In a new study, researchers evaluated the anti-cancer therapeutic efficacy of two structurally-unrelated small molecules, PAV-617 and PAV-951.

4 Oct 2022

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Stanford University researchers have discovered a rapid and sustainable way to synthetically produce a promising cancer-fighting compound right in the lab.

3 Oct 2022

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Researchers investigated the use of aminoadamantane nitrate compounds as anti-SARS-CoV-2 drugs.

3 Oct 2022

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

In a new study, researchers explored the crystalline structure of the monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor.

30 Sep 2022

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

A Brazilian study published in the journal PNAS describes some of the effects infection by SARS-CoV-2 can have on the central nervous system.

30 Sep 2022

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

In a new study, researchers performed a proteomic multiple-reaction monitoring analysis of 91 pre-selected proteins using the plasma samples of 156 healthcare workers (HCW) in the United Kingdom (UK).

30 Sep 2022

Associations between potential endocrine-disrupting chemicals and female fertility in women attending fertility clinics

Researchers explored the correlation between female fertility and chemical mixtures.

30 Sep 2022

How are diet and exercise in bodybuilders associated with the gut microbiota and metabolites?

A recent study explored the diet-exercise-gut microbiome dynamics in male bodybuilders.

30 Sep 2022

Blood test could predict people's likelihood of developing long Covid

A blood test taken at the time of Covid-19 infection could predict who is most likely to develop long Covid, suggests a new small-scale study led by UCL researchers.

28 Sep 2022

Spectrometry News and Research

Ohio State researchers enter federal cooperative agreement to develop radiation biodosimetry solutions

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

Scientists reveal anti-inflammatory molecules that play an important role in aging

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

The Emerging Field of Gene Therapy with Adeno-Associated Viruses

Do phthalates in face masks pose health hazards with increased usage during the COVID-19 pandemic?

Investigating plasma signatures of platelet-derived proteins in acute pulmonary embolism

Mouse model reveals how RNA splicing defects contribute to neurodegeneration in Alzheimer's disease

Metabolite discovery offers a potential way to address metabolic conditions

Key biophysical attributes of a self-amplifying viral RNA vaccine developed for SARS-CoV-2

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

Associations between potential endocrine-disrupting chemicals and female fertility in women attending fertility clinics

How are diet and exercise in bodybuilders associated with the gut microbiota and metabolites?

Blood test could predict people's likelihood of developing long Covid

Enhancing confidence in chemical ionization spectrometry data eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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