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TSRI scientists awarded $6.6 million NIH grant to study Lassa fever virus

Scientists from The Scripps Research Institute have been awarded $6.6 million from the National Institutes of Health to lead an investigation of Lassa fever virus, the most prevalent virus-induced hemorrhagic fever disease in Africa.

14 Oct 2014

UMMS, UMMSM researchers identify key genetic pathway underlying bipolar disorder

A team of scientists led by researchers at the University of Massachusetts Medical School and the University of Miami Miller School of Medicine have identified what is likely a key genetic pathway underlying bipolar (manic depressive) disorder, a breakthrough that could lead to better drugs for treating bipolar affective disorder, as well as depression and other related mood disorders.

14 Oct 2014

LCSB scientists characterize new tumour suppressor gene

Scientists at the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have published their findings that mutations in a gene known as "ARMC5" promote the growth of benign tumours in the adrenal glands and on the meninges: ARMC5 appears to belong to the group of so-called tumour suppressor genes.

14 Oct 2014

Gene in soil-dwelling amoeba may hold key to isolating cancerous tumors

The dirt in your backyard may hold the key to isolating cancerous tumors and to potential new treatments for a host of cancers.

14 Oct 2014

Proteins linked to severe forms of ALS are less stable, suggests new study

A new study by scientists from The Scripps Research Institute, Lawrence Berkeley National Laboratory and other institutions suggests a cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

14 Oct 2014

Johnson & Johnson's sales increase 5.1% to $18.5 billion in Q3 2014

Johnson & Johnson today announced sales of $18.5 billion for the third quarter of 2014, an increase of 5.1% as compared to the third quarter of 2013. Operational results increased 5.8% and the negative impact of currency was 0.7%. Domestic sales increased 11.6%. International sales decreased 0.3%, reflecting operational growth of 1.0% and a negative currency impact of 1.3%.

14 Oct 2014

Cornell University researchers reveal details of how MERS-CoV enters host cells

Cornell University researchers have uncovered details of how the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) enters host cells, and offer possible new avenues for treatment.

14 Oct 2014

Penn State scientists find that mitochondrial disease more prevalent in older moms

The discovery of a "maternal age effect" by a team of Penn State scientists that could be used to predict the accumulation of mitochondrial DNA mutations in maternal egg cells -- and the transmission of these mutations to children -- could provide valuable insights for genetic counseling.

14 Oct 2014

Study reveals inner workings of PKA switch that regulates cellular functions, contributes to deadly disorders

A University of Utah-led study using X-rays and neutron beams has revealed the inner workings of a master switch that regulates basic cellular functions, but that also, when mutated, contributes to cancer, cardiovascular disease and other deadly disorders.

13 Oct 2014

Rockefeller University researchers gain new insight into how cholesterol processes in our body

In spite of its dangerous reputation, cholesterol is in fact an essential component of human cells. Manufactured by the cells themselves, it serves to stiffen the cell's membrane, helping to shape the cell and protect it. By mapping the structure of a key enzyme involved in cholesterol production, Rockefeller University researchers and a colleague in Italy have gained new insight into this complex molecular process.

12 Oct 2014

Recent clinical study sheds light on potential approach to more personalized care for pancreatic cancer

Pancreatic cancer is one of the deadliest cancers. Even with aggressive treatment, the prognosis is poor, with various factors stacking the odds against successful treatment: early detection is uncommon, it tends to spread quickly and recurrence is likely. However, several newer approaches show promise in increasing the response rate to pancreatic cancer treatment.

10 Oct 2014

Synthetic oil triheptanoin improves Rett syndrome, longevity

When young mice with the rodent equivalent of a rare autism spectrum disorder (ASD), called Rett syndrome, were fed a diet supplemented with the synthetic oil triheptanoin, they lived longer than mice on regular diets. Importantly, their physical and behavioral symptoms were also less severe after being on the diet, according to results of new research from The Johns Hopkins University.

10 Oct 2014

New UCLA study reveals why people with autism experience neural stem cell overgrowth after birth

People with autism spectrum disorder often experience a period of accelerated brain growth after birth. No one knows why, or whether the change is linked to any specific behavioral changes.

10 Oct 2014

CUMC researchers use innovative algorithm to find driving force behind aggressive form of glioblastoma

Using an innovative algorithm that analyzes gene regulatory and signaling networks, Columbia University Medical Center researchers have found that loss of a gene called KLHL9 is the driving force behind the most aggressive form of glioblastoma, the most common form of brain cancer.

10 Oct 2014

Study addresses the challenge of genomic heterogeneity

Known cancer-driving genomic aberrations in localized lung cancer appear to be so consistently present across tumors that a single biopsy of one region of the tumor is likely to identify most of them, according to a paper published today in Science.

10 Oct 2014

Researchers reveal new information about Protein Kinase A

Using X-rays and neutron beams, a team of researchers from the University of California, San Diego School of Medicine, University of Utah and Oak Ridge National Laboratory have teased out new information about Protein Kinase A (PKA), a ubiquitous master switch that helps regulate fundamental cellular functions like energy consumption and interactions with hormones, neurotransmitters and drugs.

10 Oct 2014

CTCs in blood of metastatic cancer patients give genomic read-out of breast cancer

The genetic fingerprint of a metastatic cancer is constantly changing, which means that the therapy that may have stopped a patient's cancer growth today, won't necessarily work tomorrow.

9 Oct 2014

GE Healthcare-Glaxo Smith Kline deal to create force in cancer testing

A recently announced deal between GE Healthcare-subsidiary Clarient and Glaxo Smith Kline will create a force in cancer testing, according to Kalorama Information. The healthcare market research publisher tracks companion products, and says that the two entities will form a multi-purpose, data analytics- and companion diagnostics-driven network of laboratories. Kalorama Information recently released a market study, Companion Diagnostics Market, for companion diagnostics such as the drug-test combinations envisioned in this deal.

9 Oct 2014

VAL-083 drug compound shows promise against non-small cell lung cancer

DelMar Pharmaceuticals, Inc., a clinical-stage oncology company, today announced the presentation of promising new data supporting the activity of its lead drug compound, VAL-083, in the treatment of non-small cell lung cancer (NSCLC) at the AACR's New Horizons in Cancer Research: Harnessing Breakthroughs – Targeting Cures. The conference takes place October 9th to 12th in Pudong, Shanghai.

9 Oct 2014

Specific perceptual learning deficit associated with Fragile X Syndrome

Researchers at Children's Hospital Los Angeles have described for the first time a specific perceptual learning deficit in mice with a mutation of the same gene as found in children with Fragile X Syndrome (FXS).

9 Oct 2014

Mutation News and Research

TSRI scientists awarded $6.6 million NIH grant to study Lassa fever virus

UMMS, UMMSM researchers identify key genetic pathway underlying bipolar disorder

LCSB scientists characterize new tumour suppressor gene

Gene in soil-dwelling amoeba may hold key to isolating cancerous tumors

Proteins linked to severe forms of ALS are less stable, suggests new study

Johnson & Johnson's sales increase 5.1% to $18.5 billion in Q3 2014

Cornell University researchers reveal details of how MERS-CoV enters host cells

Penn State scientists find that mitochondrial disease more prevalent in older moms

Study reveals inner workings of PKA switch that regulates cellular functions, contributes to deadly disorders

Rockefeller University researchers gain new insight into how cholesterol processes in our body

Recent clinical study sheds light on potential approach to more personalized care for pancreatic cancer

Synthetic oil triheptanoin improves Rett syndrome, longevity

New UCLA study reveals why people with autism experience neural stem cell overgrowth after birth

CUMC researchers use innovative algorithm to find driving force behind aggressive form of glioblastoma

Study addresses the challenge of genomic heterogeneity

Researchers reveal new information about Protein Kinase A

CTCs in blood of metastatic cancer patients give genomic read-out of breast cancer

GE Healthcare-Glaxo Smith Kline deal to create force in cancer testing

VAL-083 drug compound shows promise against non-small cell lung cancer

Specific perceptual learning deficit associated with Fragile X Syndrome

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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