Mutation News and Research

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BRCA mutations carry risks for salivary gland cancer, breast cancer

The risk of developing cancer in a salivary gland might be higher in people with mutations in either of two genes associated with breast and ovarian cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

9 Oct 2014

AT2101 drug, evaluated for Gaucher disease, slows progression of Parkinson's disease in mice

A new study from UCLA found that a drug being evaluated to treat an entirely different disorder helped slow the progression of Parkinson's disease in mice.

9 Oct 2014

Study: H7N9 flu vaccine combined with adjuvant is essential to promote protective immune response

A large, NIH-sponsored clinical trial of an experimental H7N9 avian influenza vaccine found an immune response that was believed to be protective in 59 percent of study participants who received two injections of the inactivated vaccine at the lowest dosage tested when mixed with an adjuvant – a component that boosts the body's immune response and enhances the effectiveness of inactivated influenza vaccines.

8 Oct 2014

UW-Madison's Yoshihiro Kawaoka recognized for efforts to prevent pandemic influenza

The University of Wisconsin-Madison's Yoshihiro Kawaoka has been recognized as a 2014 Popular Mechanics Breakthrough Award recipient for his efforts to understand and prevent pandemic influenza.

8 Oct 2014

USC scientists find new way to suppress obesity

Imagine being able to take a pill that lets you eat all of the ice cream, cookies, and cakes that you wanted – without gaining any weight.

7 Oct 2014

Scientists show how BRCA2 protein works to repair damaged DNA

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA.

6 Oct 2014

Researchers discover rare disease that affects heart rate, intestinal movements

Physicians and researchers at CHU Sainte-Justine, Universit- de Montr-al, CHU de Qu-bec, Universit- Laval, and Hubrecht Institute have discovered a rare disease affecting both heart rate and intestinal movements.

6 Oct 2014

TyrRS enzyme protects DNA during cellular stress

Scientists at The Scripps Research Institute have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress.

3 Oct 2014

Diet may influence susceptibility to autoinflammatory bone disease in at-risk individuals

Diet-induced changes in the gut's bacterial ecosystem can alter susceptibility to an autoinflammatory bone disease by modifying the immune response, St. Jude Children's Research Hospital scientists reported. The findings appeared September 28 as an advanced online publication of the scientific journal Nature.

3 Oct 2014

IRCM researchers discover mechanism that promotes progression of medulloblastoma

Scientists at the IRCM discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumour found in children. The team, led by Fr-d-ric Charron, PhD, found that a protein known as Sonic Hedgehog induces DNA damage, which causes the cancer to develop.

3 Oct 2014

Viewpoints: Another troubled website rollout; insurers fight consumer measures in Calif.

If the federal government's new Open Payments website were a consumer product, it would be returned to the manufacturer for a full refund. Open Payments is the government's site for publishing payments made to doctors and teaching hospitals by drug and medical device manufacturers. It includes 4.4 million payments, worth $3.5 billion, to more than half a million doctors and almost 1,360 teaching hospitals (Charles Ornstein, 10/1).

3 Oct 2014

Women can now take proactive steps to reduce breast cancer risk

Now that medical professionals have identified gene mutations that predispose for breast cancer, patients can take proactive steps to reduce their risk.

3 Oct 2014

ERK and JNK enzymes may offer solutions for treating endometrial, colon cancers

In the quest to solve cancer's mysteries, they come in handy when describing tongue-twisting processes and pathways that somehow allow tumors to form and thrive. Two examples are ERK (extracellular-signal-related kinase) and JNK (c-June N-Terminal Kinase), enzymes that may offer unexpected solutions for treating some endometrial and colon cancers.

3 Oct 2014

Empirical sulphonylurea therapy an option for neonatal diabetes

A report of empirical sulphonylurea therapy in neonatal diabetes prior to genetic diagnosis highlights contrasting approaches to the problem.

2 Oct 2014

Gaucher disease: an interview with Dr Clement Olivier, Shire

Gaucher disease is the most common condition within a family of rare diseases known as the lysosomal storage diseases. The disease causes lipids to accumulate in cells, which is why it is referred to as a storage disorder. The accumulation occurs mainly in the spleen, liver, and bones, but may also occur in the lungs, heart, and central nervous system.

30 Sep 2014

Trovagene begins new study to assess precision cancer monitoring technology in lung cancer management

Trovagene, Inc., a developer of cell-free molecular diagnostics, announced today that it has expanded its clinical program to include a study designed to evaluate use of the Company's precision cancer monitoring technology in the management of lung cancer patients.

30 Sep 2014

Combination treatment prevents disease progression in patients with advanced melanoma

New data announced today has demonstrated that combinational treatment of cobimetinib with Zelboraf (vemurafenib), the first personalised medicine to extend life in the first-line setting for over 30 years, in patients with advanced melanoma (BRAFV600 mutation-positive) can prevent disease progression (progression-free survival; PFS) by 9.9 months compared to 6.2 months following treatment of vemurafenib alone.

30 Sep 2014

AZD9291 shows median progression-free survival in patients with EGFRm T790M+ advanced NSCLC

Updated data from the ongoing AURA study of AZD9291 shows encouraging, although still immature, median progression free survival of 9.6 months (95% CI 8.3 to NC) in patients with epidermal growth factor receptor mutation positive (EGFRm) T790M+ advanced non-small cell lung cancer (NSCLC) who had disease progression following treatment with an EGFR tyrosine kinase inhibitor (EGFR TKI).

30 Sep 2014

Researchers uncover molecular interaction between key proteins in cell division

Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos' Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG, key proteins in forming the internal cellular framework that enables and sustains cell division.

30 Sep 2014

Pemetrexed/docetaxel with cisplatin achieve similar progression-free survival in NSCLC patients

The first direct comparison of treating non-squamous lung cancer with either pemetrexed or docetaxel in addition to cisplatin has shown that the two combinations achieve similar progression-free survival, although docetaxel was associated with more frequent adverse events.

30 Sep 2014

Mutation News and Research

BRCA mutations carry risks for salivary gland cancer, breast cancer

AT2101 drug, evaluated for Gaucher disease, slows progression of Parkinson's disease in mice

Study: H7N9 flu vaccine combined with adjuvant is essential to promote protective immune response

UW-Madison's Yoshihiro Kawaoka recognized for efforts to prevent pandemic influenza

USC scientists find new way to suppress obesity

Scientists show how BRCA2 protein works to repair damaged DNA

Researchers discover rare disease that affects heart rate, intestinal movements

TyrRS enzyme protects DNA during cellular stress

Diet may influence susceptibility to autoinflammatory bone disease in at-risk individuals

IRCM researchers discover mechanism that promotes progression of medulloblastoma

Viewpoints: Another troubled website rollout; insurers fight consumer measures in Calif.

Women can now take proactive steps to reduce breast cancer risk

ERK and JNK enzymes may offer solutions for treating endometrial, colon cancers

Empirical sulphonylurea therapy an option for neonatal diabetes

Gaucher disease: an interview with Dr Clement Olivier, Shire

Trovagene begins new study to assess precision cancer monitoring technology in lung cancer management

Combination treatment prevents disease progression in patients with advanced melanoma

AZD9291 shows median progression-free survival in patients with EGFRm T790M+ advanced NSCLC

Researchers uncover molecular interaction between key proteins in cell division

Pemetrexed/docetaxel with cisplatin achieve similar progression-free survival in NSCLC patients

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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