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Notch1 and Jagged1 genes are likely markers indicating a patient's probable aggressive breast cancer

In a new study, scientists at The Hospital for Sick Children and Princess Margaret Hospital have shown that two genes called Notch1 and Jagged1 are linked to more aggressive breast cancers and that patients are less likely to survive the disease when these two genes are highly expressed.

26 Sep 2005

New approach to treating brain aneurysm combining the use of intracranial stents and coil embolization

A fender-bender may have saved Douglas Collins' life. A CT scan following the accident discovered Collins, 64, had a brain aneurysm, a weakness in the arterial wall that if ruptured could cause a stroke or death. It was not caused by the accident, but likely could have been a ticking time bomb present for years. The aneurysm was large and previously thought to require open surgery and a lengthy recovery.

26 Sep 2005

Questionnaire helps identify women who have inherited genetic mutations that increase their risk for breast or ovarian cancer

A simplified way for patients to report and update their family medical histories could help identify women who have inherited genetic mutations that increase their risk for breast or ovarian cancer.

26 Sep 2005

People use discretion in deciding when show up in the emergency department

When is a medical emergency really an emergency? Not during key Boston Red Sox games, report investigators from Children's Hospital Boston in a letter published in the October issue of Annals of Emergency Medicine.

26 Sep 2005

Neurologix announces positive interim results of gene therapy clinical trial for patients with Parkinson's disease

Neurologix has announced positive interim results of its landmark gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase I trial is the world's first study to use a viral vector (the non-pathogenic adeno-associated virus, or AAV) for the treatment of an adult neurological disease.

26 Sep 2005

Study shows that nursing homes should consider diabetes a significant risk factor for falling

Falling is the leading cause of accidental death for elderly people, and a new study from Columbia University Medical Center and NewYork-Presbyterian Hospital/The Allen Pavilion suggests that nursing home residents with diabetes are four times more likely to fall than those who are not diabetic.

26 Sep 2005

Leaving deprivation out of standard risk assessments for heart disease is potentially denying life saving treatment to those who need it most

A person's estimated chances of developing heart disease, and being allocated "primary preventive" treatment, is currently calculated using the standard risk factors of smoking, blood pressure, cholesterol, age, sex, and diabetes. These are typically pulled together in the internationally used Framingham Risk Score.

26 Sep 2005

Change in gene may be underlying molecular defect in some colorectal cancers

Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer, according to a new study in the current issue of the Journal of the National Cancer Institute.

22 Sep 2005

Presence of environmental chemicals in human milk does not necessarily indicate health risks for infants

"We strongly emphasize that the mere presence of an environmental chemical in human milk does not indicate that a health risk exists for breast-fed infants," said Cheston M. Berlin, Jr., M.D., Penn State University professor of pediatrics and pharmacology.

22 Sep 2005

Long-term alcoholics are at a higher risk for postoperative infections following elective cardiac surgery

Previous research has shown that post-surgery rates of disease and death are two-to-five times greater among long-term alcoholics than nonalcoholic patients. Of all the possible complications, infection can be the most serious.

22 Sep 2005

$Genetic factors influence elderly individual's propensity to bone fractures$

Genetic factors influence elderly individual's propensity to bone fractures

The importance of genetic factors in an elderly individual's propensity to bone fractures depends on the individual's age and the type of fracture, according to a study in the Archives of Internal Medicine.

21 Sep 2005

Pediatricians may fail to diagnose obesity in kids

Many physicians may be missing the chance to talk to obese children and their parents about ways to control the children's weight, according to Saint Louis University research reported in Pediatrics.

21 Sep 2005

Scintigraphy scan may help clinicians properly diagnose and then treat two forms of cardiac amyloidosis

"Clinically, this finding helps differential diagnosis and reduces the risk of misdiagnosis between two conditions with very different therapeutic options," said Claudio Rapezzi, M.D. from the University of Bologna and S. Orsola-Malpighi Hospital in Bologna, Italy.

21 Sep 2005

Antibiotic resistance has put humans in an escalating 'arms race' with infectious bacteria

...as scientists try to develop new antibiotics faster than the bacteria can evolve new resistance strategies. But now, researchers have a new strategy that may give them a leg up in the race -- reproducing in the lab the natural evolution of the bacterial enzymes that confer resistance.

21 Sep 2005

Digital mammography detects more cancers than screen film mammography

A landmark breast cancer screening trial shows that digital mammography detected more cancers - up to 28 percent more - than screen film mammography in women 50 and younger, premenopausal and perimenopausal women, and women with dense breasts.

21 Sep 2005

First true animal model for psoriasis

Scientists at the Research Institute of Molecular Pathology in Vienna have developed the first true animal model for psoriasis and have been able to address the initial steps and possible causes of the disease.

20 Sep 2005

Gene mutation may increase the risk of prostate cancer up to three times in African-American

Researchers have identified a gene mutation that may increase the risk of prostate cancer up to three times in African-American men with a family history of the disease.

20 Sep 2005

Change in gene may be underlying molecular defect in some colorectal cancers

Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer, according to a new study in the September 21 issue of the Journal of the National Cancer Institute.

20 Sep 2005

Family-centered approach improves communication and care in intensive care unit

A nationwide hospital program developed to support families visiting loved ones in the intensive care unit (ICU) has significant benefits for families, patients, and team members in the ICU, shows a new study.

20 Sep 2005

Important new lessons learned from aspirin

No other medicine is as common, inexpensive, and yet powerful in so many ways as aspirin; yet despite a century of experience with the drug, researchers are still learning important new lessons, while raising new questions, according to seven special articles in the Sept. 20, 2005, issue of the Journal of the American College of Cardiology.

20 Sep 2005

Hospital News and Research

Notch1 and Jagged1 genes are likely markers indicating a patient's probable aggressive breast cancer

New approach to treating brain aneurysm combining the use of intracranial stents and coil embolization

Questionnaire helps identify women who have inherited genetic mutations that increase their risk for breast or ovarian cancer

People use discretion in deciding when show up in the emergency department

Neurologix announces positive interim results of gene therapy clinical trial for patients with Parkinson's disease

Study shows that nursing homes should consider diabetes a significant risk factor for falling

Leaving deprivation out of standard risk assessments for heart disease is potentially denying life saving treatment to those who need it most

Change in gene may be underlying molecular defect in some colorectal cancers

Presence of environmental chemicals in human milk does not necessarily indicate health risks for infants

Long-term alcoholics are at a higher risk for postoperative infections following elective cardiac surgery

Genetic factors influence elderly individual's propensity to bone fractures

Pediatricians may fail to diagnose obesity in kids

Scintigraphy scan may help clinicians properly diagnose and then treat two forms of cardiac amyloidosis

Antibiotic resistance has put humans in an escalating 'arms race' with infectious bacteria

Digital mammography detects more cancers than screen film mammography

First true animal model for psoriasis

Gene mutation may increase the risk of prostate cancer up to three times in African-American

Change in gene may be underlying molecular defect in some colorectal cancers

Family-centered approach improves communication and care in intensive care unit

Important new lessons learned from aspirin

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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