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Suppression of FOXO1a gene might kill resistant alveolar rhabdomyosarcoma (ARMS) tumors

FOXO1a caused death of tumor cells in laboratory study by triggering expression of caspase-3, which blocks cell division and causes cells to undergo apoptosis, according to St. Jude.

20 Sep 2005

PUMA protein offers critical insights for developing new anti-cancer drugs

The discovery of how the activities of the protein p53 initiate signals that trigger cell suicide offers critical insights for developing new anti-cancer drugs, according to investigators from St. Jude Children's Research Hospital.

20 Sep 2005

High-fat fare increases risk of heart disease for hospital staff and visitors

Nutrition scientists with the Physicians Committee for Responsible Medicine (PCRM) have conducted a nationwide survey to determine if hospital cafeterias and restaurants are meeting the need for low-fat, cholesterol-free foods that can help people maintain a healthy weight and prevent heart disease, diabetes, and some cancers.

19 Sep 2005

Healthcare workers show general apathy towards the flu vaccination

Low flu vaccination rates among healthcare workers could be risking the lives of frail elderly patients and increasing winter pressures in UK hospitals, according to research published in the latest issue of Journal of Clinical Nursing.

19 Sep 2005

Public hospital patients are often denied access to Laparoscopic Adjustable Gastric Banding (LAGB) surgery

Public hospital patients are often denied access to one of the most effective forms of weight loss treatment Laparoscopic Adjustable Gastric Banding (LAGB) surgery, a Monash expert says.

19 Sep 2005

More than two thirds of meta-analyses available to critical care physicians have major methodological flaws

Research published in Critical Care concludes that the overall quality of meta-analyses in this field is poor, but has improved over time, possibly due to the publication of the Quality of Reporting of Meta-analyses statement (QUOROM) in 1999.

19 Sep 2005

Acute-leukemia sign may signal need for different therapy

A type of chromosome change that was thought to predict a good response to treatment in patients with acute myeloid leukemia (AML) might actually signal the need for a different therapy to achieve the best outcome.

19 Sep 2005

Researchers detail molecular images of a piece of the spike-shaped protein that the SARS virus uses initiate the first stages of infection

Researchers have determined the first detailed molecular images of a piece of the spike-shaped protein that the SARS virus uses to grab host cells and initiate the first stages of infection.

19 Sep 2005

Tarceva should be tested as front-line therapy for older lung cancer patients

The tyrosine kinase inhibitor erlotinib (Tarceva) showed encouraging activity with relatively tolerable side effects in elderly, previously untreated patients with advanced non-small cell lung cancer (NSCLC), reports a team led by investigators from Dana-Farber Cancer Institute in Boston.

19 Sep 2005

New research will play a major role in improving the future of breast cancer treatment

Cancer specialists at University of East Anglia have discovered that several 'ADAMTS' genes are turned off in breast cancer compared to normal breast tissue, while others are switched on. These genes could be targets for the development of 'smart' drugs tailored to treat individual patients' tumours.

19 Sep 2005

Natural daily body rhythms may influence the effectiveness of spinal-epidural pain medication

The study found that women who had day labor got longer pain relief than women with night labor with the same amount of labor pain medicine.

19 Sep 2005

Drug AMD-3100 may help cancer patients who need stem cell transplants

A new drug may help cancer patients mobilize the cells necessary to restore their blood-forming system after high-dose chemotherapy, according to results from a clinical trial at the Kimmel Cancer Center at Thomas Jefferson University Hospital in Philadelphia and at other centers across the nation.

19 Sep 2005

Women with atrial fibrillation face a higher risk of ischemic stroke than men

Women with atrial fibrillation who are not on anticoagulant therapy have a higher rate of ischemic stroke and face a higher absolute risk for stroke than do men with the condition, according to a joint study

19 Sep 2005

Manic depression linked to two chromosomal regions in the human genome

An international team of 53 researchers has offered the most convincing evidence so far linking bipolar disorder, also known as manic depression, to two chromosomal regions in the human genome. The finding gives scientists refined targets for further gene studies.

19 Sep 2005

MRC study to monitor Pentosan Polysulphate as a treatment for Creutzfeldt-Jakob disease receives approval

The plans for a monitoring study on patients being treated with Pentosan Polysulphate (PPS) for CJD and variant CJD have received a favourable opinion from the Eastern Multi-Centre Research Ethics Committee. This follows a provisional opinion from the committee in August.

19 Sep 2005

Does surgery induce angiogenesis in dormant breast cancer?

Analysis of breast-cancer relapse patterns from two independent databases provides indirect evidence for the theory that surgery to remove the primary tumor may initiate formation of a new blood supply (angiogenesis) in formerly dormant metastases, accounting for a pattern of early relapse in younger women.

12 Sep 2005

Healthcare workers may be unable or unwilling to report to work during certain disasters

In a first study of its kind, researchers at the Mailman School of Public Health assessed the ability and willingness of healthcare workers to report to work in the event of disasters involving weapons of mass destruction or virulent infectious disease outbreaks.

12 Sep 2005

Women who suffer heart attacks wait longer to be assessed

Women who suffer heart attacks wait longer to be assessed, admitted and receive treatment than men with the same condition, according to a paper in the latest Journal of Advanced Nursing.

12 Sep 2005

Helix receives approval to conduct a clinical trial of Topical Interferon Alpha-2b in Sweden

Helix BioPharma today announced that it has received approval from Sweden's drug regulatory authority, the Medical Products Agency (MPA), to conduct a Phase II clinical trial of Topical Interferon Alpha-2b in patients with ano-genital warts (condylomata acuminata), who are positive for infection with the human papilloma virus (HPV).

12 Sep 2005

Need for more outdoor play spaces so that children could have more choice over materials, locations and playmates

Young children may be missing out on 'pretend' games like pirates and spacemen due to the demands of the school curriculum, according to research funded by the Economic and Social Research Council (ESRC).

12 Sep 2005

Hospital News and Research

Suppression of FOXO1a gene might kill resistant alveolar rhabdomyosarcoma (ARMS) tumors

PUMA protein offers critical insights for developing new anti-cancer drugs

High-fat fare increases risk of heart disease for hospital staff and visitors

Healthcare workers show general apathy towards the flu vaccination

Public hospital patients are often denied access to Laparoscopic Adjustable Gastric Banding (LAGB) surgery

More than two thirds of meta-analyses available to critical care physicians have major methodological flaws

Acute-leukemia sign may signal need for different therapy

Researchers detail molecular images of a piece of the spike-shaped protein that the SARS virus uses initiate the first stages of infection

Tarceva should be tested as front-line therapy for older lung cancer patients

New research will play a major role in improving the future of breast cancer treatment

Natural daily body rhythms may influence the effectiveness of spinal-epidural pain medication

Drug AMD-3100 may help cancer patients who need stem cell transplants

Women with atrial fibrillation face a higher risk of ischemic stroke than men

Manic depression linked to two chromosomal regions in the human genome

MRC study to monitor Pentosan Polysulphate as a treatment for Creutzfeldt-Jakob disease receives approval

Does surgery induce angiogenesis in dormant breast cancer?

Healthcare workers may be unable or unwilling to report to work during certain disasters

Women who suffer heart attacks wait longer to be assessed

Helix receives approval to conduct a clinical trial of Topical Interferon Alpha-2b in Sweden

Need for more outdoor play spaces so that children could have more choice over materials, locations and playmates

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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