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Maintaining proper oxygen supply in tumors could be key factor to stop progression of cancer

The lack of oxygen in tumor cells changes the cells' gene expression, thereby contributing to the growth of cancer.

18 Aug 2016

Salk researchers identify new mechanism for Alzheimer's risk gene

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

18 Aug 2016

Study finds 10% of patients admitted into hospitals colonised with dreaded pathogens

According to National Reference Center for Surveillance of Nosocomial Infections esti-mates, up to 15,000 patients die of hospital-acquired infections in Germany every year.

18 Aug 2016

Research article outlines utilization of calixarenes in biocatalysis and cancer therapy

Calixarenes bear a fascinating class of macrocycles that have served broadly in molecular recognition and supramolecular chemistry.

17 Aug 2016

TSRI scientists tackle decades-old challenge by re-creating primordial RNA world

Scientists at The Scripps Research Institute (TSRI) have taken a big step toward the laboratory re-creation of the “RNA world,” which is generally believed to have preceded modern life forms based on DNA and proteins.

17 Aug 2016

Researchers discover new set of bacterial cell wall synthesizers

Harvard Medical School scientists have identified a new family of proteins that virtually all bacteria use to build and maintain their cell walls.

17 Aug 2016

MGH investigators discover key molecules essential for sensing proteasome dysfunction

Maintaining appropriate levels of proteins within cells largely relies on a cellular component called the proteasome, which degrades unneeded or defective proteins to recycle the components for the eventual assembly of new proteins.

16 Aug 2016

Researchers explain why secondary infection with MRSA kills influenza patients

Researchers have discovered that secondary infection with the Methicillin-resistant Staphylococcus aureus (MRSA) bacterium (or "superbug") often kills influenza patients because the flu virus alters the antibacterial response of white blood cells, causing them to damage the patients' lungs instead of destroying the bacterium.

16 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Intestinal flora likely to have effect on person's response to drugs

Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs.

12 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

A novel PET radiotracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital is able for the first time to reveal epigenetic activity - the process that determines whether or not genes are expressed - within the human brain.

11 Aug 2016

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis.

10 Aug 2016

Geneticists identify enzyme that regulates chromosome segregation during meiosis

GENETICISTS have identified an enzyme which regulates the production of sperm and egg cells in human reproduction.

10 Aug 2016

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2016

Rare genetic variations linked to severe porphyria

An international research team has linked rare variations in a cell membrane protein to the wide variation in symptom severity that is a hallmark of porphyria, a rare disorder that often affects the skin, liver and nervous system.

10 Aug 2016

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data.

10 Aug 2016

Study finds reduced activity of ACMSD enzyme in people with suicidal behavior

It is known that people who have attempted suicide have ongoing inflammation in their blood and spinal fluid. Now, a collaborative study from research teams in the U.S., Sweden and Australia published in Translational Psychiatry shows that suicidal patients have a reduced activity of an enzyme that regulates inflammation and its byproducts.

10 Aug 2016

Research findings could lead to development of improved breast cancer drugs

Biomedical scientists have revealed the inner workings of a group of proteins that help to switch critical genes on and off during blood-cell production, in a finding that could lead to the development of new and improved cancer drugs.

9 Aug 2016

Researchers shed new light on roots of dystonia

Researchers at VIB-KU Leuven have managed to get a clearer view on the roots of dystonia, a neurological disorder that causes involuntary twisting movements.

9 Aug 2016

Enzyme News and Research

Maintaining proper oxygen supply in tumors could be key factor to stop progression of cancer

Salk researchers identify new mechanism for Alzheimer's risk gene

Study finds 10% of patients admitted into hospitals colonised with dreaded pathogens

Research article outlines utilization of calixarenes in biocatalysis and cancer therapy

TSRI scientists tackle decades-old challenge by re-creating primordial RNA world

Researchers discover new set of bacterial cell wall synthesizers

MGH investigators discover key molecules essential for sensing proteasome dysfunction

Researchers explain why secondary infection with MRSA kills influenza patients

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Intestinal flora likely to have effect on person's response to drugs

Novel computational analysis of prostate cancer suggests potential targets for therapy

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Geneticists identify enzyme that regulates chromosome segregation during meiosis

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Rare genetic variations linked to severe porphyria

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Study finds reduced activity of ACMSD enzyme in people with suicidal behavior

Research findings could lead to development of improved breast cancer drugs

Researchers shed new light on roots of dystonia

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