Liver News and Research

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HBsAg may persist in chronic HBV patients beyond seroclearance

The use of a highly sensitive assay for the detection of hepatitis B surface antigen suggests that HBsAg negativity as evaluated by the conventional test may not be indicative of seroclearance in patients with chronic hepatitis B virus infection.

3 Dec 2015

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Lexicon Pharmaceuticals, Inc. announced today that top-line data from its TELECAST Phase 3 study showed results of telotristat etiprate in treating carcinoid syndrome in cancer patients with metastatic neuroendocrine tumors consistent with the clinical benefit observed in its pivotal TELESTAR study.

1 Dec 2015

Combination of antiviral medications can eradicate HCV infection in patients with advanced liver disease

A large multi-center clinical trial has found that a combination of antiviral medications can eradicate hepatitis C infection in more than 90 percent of patients with advanced liver disease. Known as the ASTRAL-4 trial, the study was co-led by investigators at Beth Israel Deaconess Medical Center and Intermountain Medical Center and published online Nov. 17 in The New England Journal of Medicine.

1 Dec 2015

Philips launches IntelliSpace Portal 8.0 platform for diagnosis and treatment of cancer

Strengthening its leadership in connected healthcare informatics, Royal Philips (NYSE: PHG, AEX: PHIA) today announced IntelliSpace Portal 8.0 , the latest edition of its advanced data sharing, analytics and visualization platform that helps radiologists detect, diagnose and follow-up on treatment of diseases.

1 Dec 2015

Researchers discover drug target and genetic pathway for graft-versus-host disease

A Seattle Children's Research Institute lab has discovered a genetic pathway that can be targeted with existing drugs to prevent graft-versus-host disease (GVHD), a common and deadly complication of bone marrow transplants.

30 Nov 2015

Six-month markers predict long-term cGVHD outcomes

Researchers have identified measures early in the course of chronic graft-versus-host disease that predict long-term prognosis in haematopoietic cell transplantation recipients.

27 Nov 2015

Can-Fite BioPharma reports financial results, provides updates on drug development programs

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs being developed to treat inflammatory diseases, cancer and sexual dysfunction, today reported financial results for the nine months ended September 30, 2015 and updates on its drug development programs.

27 Nov 2015

Scientists show how malaria parasites invade the liver

Scientists at the Center for Infectious Disease Research recently uncovered a critical piece in the puzzle of how malaria parasites infect their host. The work, recently published in Science Magazine, reveals the details of how the malaria parasite invades its initial target organ, the liver. Without infection of the liver, the parasites cannot multiply or spread to the blood. Infection of the blood causes illness, spread of the disease, and, ultimately, death.

27 Nov 2015

Researchers reveal new technique to grow human hepatocytes in the laboratory

In new research appearing in the prestigious journal Nature Biotechnology, an international research team led by The Hebrew University of Jerusalem describes a new technique for growing human hepatocytes in the laboratory. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations.

27 Nov 2015

Obese children with NAFLD not meeting recommended physical activity levels

In a new study published today in the journal Nutrients, research from the University of Surrey and the Children's Liver Disease Foundation has found that both obese children and those with Non-Alcoholic Fatty Liver Disease (NAFLD) are not meeting the UK recommendations for a variety of vitamins and minerals.

26 Nov 2015

Opsin proteins contribute to heat-seeking movement of sperm

In their arduous journey to the egg, sperm "feel" the heat of the fallopian tube and "taste" the chemical signals of the ova. But a new Weizmann Institute of Science study published in Scientific Reports, in Nature, shows that sperm actually make quite a bit of use of sensors that have mainly been known to belong to the visual system.

26 Nov 2015

Key finding aids quest to produce liver cell therapies

Stem cell scientists have made a key find that aids the quest to produce therapies for patients with liver damage.

26 Nov 2015

Bile pigment may provide natural protection from heart attacks

New hope in the fight against cardiovascular disease has arrived, following breakthrough research identifying a pigment in our bile which could protect us.

26 Nov 2015

EDDA Technology receives FDA clearance for IQQA-Guide system for surgical procedures

EDDA Technology, a global leading provider in advanced imaging-guided precision treatment solutions, announced today that the company has received FDA clearance on IQQA-Guide, a system that supports intra-operative precision 3D navigation for surgical procedures of thoracic, abdominal, and pelvic soft-organs.

25 Nov 2015

Research brings scientists closer to understanding mechanisms underlying genomic imprinting process

Research led by Dr. Keiji Tanimoto from the University of Tsukuba, Japan, has brought us closer to understanding the mechanisms underlying the phenomenon of genomic imprinting.

25 Nov 2015

New mathematical model forecasts metastatic breast cancer survival rates

USC researchers have developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting and surfing the Web.

24 Nov 2015

Opdivo (nivolumab) approved to treat patients with advanced renal cell carcinoma

The U.S. Food and Drug Administration today approved Opdivo (nivolumab) to treat patients with advanced (metastatic) renal cell carcinoma, a form of kidney cancer, who have received a certain type of prior therapy.

23 Nov 2015

Findings could offer doctors new method to diagnose pancreatic cancer earlier in patients

By collecting samples from the portal vein--which carries blood from the gastrointestinal tract, including from the pancreas, to the liver--physicians can learn far more about a patient's pancreatic cancer than by relying on peripheral blood from a more easily accessed vein in the arm.

23 Nov 2015

Liver's cannabinoid receptors could be targeted to combat liver cancer in some patients

A new study reveals that the liver's cannabinoid receptors could be targeted to fight liver cancer in some patients; and it offers a way to predict what treatments have the best chance of working.

23 Nov 2015

Compared to monotherapy combination of pills for advanced skin cancer extends survival

The combination of cobimetinib and Zelboraf® (vemurafenib) has been shown to extend the lives of previously untreated patients with advanced skin cancer to nearly two years (22.3 months)

23 Nov 2015

Liver News and Research

HBsAg may persist in chronic HBV patients beyond seroclearance

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Combination of antiviral medications can eradicate HCV infection in patients with advanced liver disease

Philips launches IntelliSpace Portal 8.0 platform for diagnosis and treatment of cancer

Researchers discover drug target and genetic pathway for graft-versus-host disease

Six-month markers predict long-term cGVHD outcomes

Can-Fite BioPharma reports financial results, provides updates on drug development programs

Scientists show how malaria parasites invade the liver

Researchers reveal new technique to grow human hepatocytes in the laboratory

Obese children with NAFLD not meeting recommended physical activity levels

Opsin proteins contribute to heat-seeking movement of sperm

Key finding aids quest to produce liver cell therapies

Bile pigment may provide natural protection from heart attacks

EDDA Technology receives FDA clearance for IQQA-Guide system for surgical procedures

Research brings scientists closer to understanding mechanisms underlying genomic imprinting process

New mathematical model forecasts metastatic breast cancer survival rates

Opdivo (nivolumab) approved to treat patients with advanced renal cell carcinoma

Findings could offer doctors new method to diagnose pancreatic cancer earlier in patients

Liver's cannabinoid receptors could be targeted to combat liver cancer in some patients

Compared to monotherapy combination of pills for advanced skin cancer extends survival

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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