Mutation News and Research

RSS

New genetic barcode helps identify different types of tuberculosis

Doctors and researchers will be able to easily identify different types of tuberculosis (TB) thanks to a new genetic barcode devised by scientists from the London School of Hygiene & Tropical Medicine.

2 Sep 2014

Internal production of hydrogen peroxide can lead cells to exit cell cycle and become senescent

What happens inside cells when they detect the activation of a cancer-inducing gene? Sometimes, cells are able to signal internally to stop the cell cycle. Such cells are able to enter, at least for a time, a protective non-growth state.

30 Aug 2014

Dartmouth researchers evaluate role of assortativity signature on robustness

Dartmouth researchers explored the type and number of connections in transcription factor networks (TFNs) to evaluate the role assortativity plays on robustness in a study published in PLOS Computational Biology in August.

30 Aug 2014

Researchers explore connections in TFNs to evaluate role assortativity plays on robustness

30 Aug 2014

Irinotecan-based therapy improves survival rates for patients with stage III colon cancer

A subset of patients with stage III colon cancer had improved survival rates when treated with irinotecan-based therapy, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association.

29 Aug 2014

Minnesota researchers develop animal research model for FSHD

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

29 Aug 2014

Pharmatech begins enrollment for AccessPPM program

Pharmatech initiated enrollment for its AccessPPM program after a two-year investment into this game-changing method for matching cancer patients to cancer clinical trials.

29 Aug 2014

BloodCenter's Erythroid Chimerism test available to monitor transplanted SCD patients

BloodCenter of Wisconsin's Diagnostic Laboratories today announced the availability of an innovative Erythroid Chimerism test to monitor erythroid lineage chimerism in patients with sickle cell disease (SCD) following allogeneic bone marrow transplantation.

28 Aug 2014

Amgen seeks FDA approval for evolocumab to treat patients with high cholesterol

Amgen today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration for evolocumab seeking approval for the treatment of high cholesterol.

28 Aug 2014

Mutant allele frequency predicts lung cancer TKI response

Tyrosine kinase inhibitor sensitivity may be predicted by the frequency of a point mutation in the epidermal growth factor receptor gene, suggests a study of Japanese patients with advanced lung adenocarcinoma.

28 Aug 2014

High PD-L1 expression linked to reduced survival in NSCLC

Overexpression of programmed death-ligand 1 is independently associated with the presence of epidermal growth factor receptor gene mutations and poor prognosis in patients with non-small-cell lung cancer, Japanese researchers report.

28 Aug 2014

Ames test successfully adapted for use with cigarette smoke and other complex aerosols

The Ames test, a widely used method to determine whether a chemical has the potential to cause cancer, has been successfully adapted for use with cigarette smoke and other complex aerosols.

27 Aug 2014

Scientists pave way for improved tools to diagnose, predict and monitor cancer

Scientists have shown how to better identify and measure vital molecules that control cell behaviour - paving the way for improved tools for diagnosis, prediction and monitoring of cancer.

From The University of Manchester 27 Aug 2014

Scientists find that DNA repair drug could help treat leukaemia, other cancers

A team of scientists led by Research Associate Professor Motomi Osato and Professor Yoshiaki Ito from the Cancer Science Institute of Singapore at the National University of Singapore found that a drug originally designed for killing a limited type of cancer cells with DNA repair defects could potentially be used to treat leukaemia and other cancers.

26 Aug 2014

Ruthigen gets DMC recommendation to begin RUT58-60 Phase 1/2 clinical trial

Ruthigen Inc., a biopharmaceutical company focused on improving patient outcomes and reducing healthcare costs in invasive procedures, has announced that its lead drug candidate, RUT58-60, has received a recommendation from the Data Monitoring Committee to begin enrolling patients in the Company's planned Phase 1/2 clinical trial.

26 Aug 2014

Scientists pave way for improved tools to predict and monitor cancer

Scientists have shown how to better identify and measure vital molecules that control cell behaviour - paving the way for improved tools for diagnosis, prediction and monitoring of cancer.

From The University of Manchester 26 Aug 2014

Repurposing anti-depressant medication to target new pathway may help combat medulloblastoma

An international research team reports in Nature Medicine a novel molecular pathway that causes an aggressive form of medulloblastoma, and suggests repurposing an anti-depressant medication to target the new pathway may help combat one of the most common brain cancers in children.

26 Aug 2014

Experts available to share tips on prevention of ovarian cancer

Ovarian cancer is the fourth leading cause of death in American women, with about 22,000 diagnosed and 14,000 dying from the disease each year. September is Ovarian Cancer Awareness month and Mount Sinai experts are sharing tips on prevention.

26 Aug 2014

Drug to kill limited type of cancer cells with DNA repair defects could treat leukaemia

A team of scientists led by Research Associate Professor Motomi Osato and Professor Yoshiaki Ito from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) found that a drug originally designed for killing a limited type of cancer cells with DNA repair defects could potentially be used to treat leukaemia and other cancers.

26 Aug 2014

Researchers find why certain glioblastomas become drug resistance

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas - the primary form of a deadly brain cancer - are resistant to drug therapy.

26 Aug 2014