Liver News and Research

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Diet missing soluble fiber promotes inflammation in the intestines, leading to weight gain

Eating too much high-fat, high-calorie food is considered the primary cause of obesity and obesity-related disease, including diabetes. While the excess calories consumed are a direct cause of the fat accumulation, scientists suspect that low-grade inflammation due to an altered gut microbiome may also be involved.

30 Oct 2015

Discovery may allow physicians to warn patients years before onset of diabetes

A panel of markers have been discovered that helps identify if a person is pre-diabetic by measuring the fatty acids in their blood. This discovery by University of Hawai'i Cancer Center researchers may allow physicians to warn patients years before the onset of diabetes, therefore allowing them to change their lifestyle patterns potentially avoiding the diagnosis of a chronic disease.

30 Oct 2015

Isis Pharmaceuticals begins ISIS-FXI Rx Phase 2 study in patients with ESRD on hemodialysis

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 study evaluating ISIS-FXIRx in patients with end-stage renal disease (ESRD) on hemodialysis. In May 2015, Isis entered into an exclusive license agreement with Bayer HealthCare (Bayer) to develop and commercialize ISIS-FXIRx for the prevention of clotting disorders.

30 Oct 2015

Gut bacteria may increase risk of metabolic syndrome

An excess of bacteria in the gut can change the way the liver processes fat and could lead to the development of metabolic syndrome, according to health researchers.

30 Oct 2015

SLU hepatologist receives $150,000 grant to study preventative strategies for TPN-associated disorders

When a child is born prematurely, providing nutrition intravenously can be lifesaver. Unfortunately it can also cause liver damage down the road.

29 Oct 2015

Certain drugs could be used to treat gastric cancers with particular pattern of mutations

Gastric cancer, otherwise known as stomach cancer, does not respond well to existing treatments and it is currently the third leading cause of cancer death in the world (after lung and liver cancer). Researchers have discovered that certain drugs, currently used to treat breast, ovarian and pancreatic cancers, could also be used to treat certain gastric cancers with a particular pattern of mutations (genomic molecular fingerprint).

29 Oct 2015

Yervoy approved for patients at high risk of developing recurrence of melanoma after surgery

Today the U.S. Food and Drug Administration expanded the approved use of Yervoy (ipilimumab) to include a new use as adjuvant therapy for patients with stage III melanoma, to lower the risk that the melanoma will return following surgery.

29 Oct 2015

Cancer diagnosis improvements in England: an interview with Lucy Elliss-Brookes

The ‘two week wait’ referral was brought into England in 2000. If a patient goes to see their GP and they meet specific criteria that cause the GP to think they might have cancer, then they should be referred to see a specialist within two weeks.

28 Oct 2015

New generation of incretin-based medicines allows coordinated action against diabesity

The new generation of incretin-based medicines will allow a coordinated action against the combination diabetes/obesity, also known as diabesity, in some cases with only a single weekly dose, and with the likelihood of additional beneficial effects on other health complications related to this condition, such as cardiovascular and neurodegenerative diseases.

28 Oct 2015

Hiroshima University researchers report promising new avenue for treating hepatitis B

A promising new avenue for treating hepatitis B has been reported by researchers at Hiroshima University who have developed a new animal model of the disease.

28 Oct 2015

Researchers uncover genes that can suppress HCV infection within the liver

University of Adelaide researchers have uncovered the role played by a family of genes, which can suppress hepatitis C virus (HCV) infection within the liver.

28 Oct 2015

Watching too much TV increases risk of death

On average, 80% of American adults watch 3.5 hours of television per day and multiple observational studies have demonstrated a link between TV viewing and poorer health. In this new study published in the December issue of the American Journal of Preventive Medicine, investigators reported an association between increasing hours of television viewing per day and increasing risk of death from most of the major causes of death in the United States.

28 Oct 2015

Research provides novel insight into potential new therapeutic targets for triple-negative breast cancer

Recent laboratory findings provide novel insight into potential new therapeutic approaches for triple-negative breast cancer, a particularly difficult to treat and aggressive form of the disease.

28 Oct 2015

Praziquantel treatment safe for pregnant women after first trimester

A study by Rhode Island Hospital researchers confirmed that a drug used to treat a disease afflicting millions of people in developing countries is safe to give pregnant women following their first trimester. The finding could prove critical to the care of pregnant women and lactating women with schistosomiasis, a disease caused by a parasitic worm, who were denied the drug out of concern for their health and the health of their fetuses.

28 Oct 2015

Imlygic approved for treatment of melanoma lesions in the skin and lymph nodes

The U.S. Food and Drug Administration today approved Imlygic (talimogene laherparepvec), the first FDA-approved oncolytic virus therapy, for the treatment of melanoma lesions in the skin and lymph nodes.

28 Oct 2015

Reducing sugar intake reverses chronic metabolic diseases in children

Reducing consumption of added sugar, even without reducing calories or losing weight, has the power to reverse a cluster of chronic metabolic diseases, including high cholesterol and blood pressure, in children in as little as 10 days, according to a study by researchers at UC San Francisco and Touro University California.

27 Oct 2015

Four microRNAs appear to play critical roles in controlling cholesterol, triglyceride metabolism

Four tiny segments of RNA appear to play critical roles in controlling cholesterol and triglyceride metabolism. In their report receiving advance online publication in Nature Medicine, a Massachusetts General Hospital-based research team describes finding how these microRNAs could reduce the expression of proteins playing key roles in the generation of beneficial HDL cholesterol, the disposal of artery-clogging LDL cholesterol, control of triglyceride levels and other risk factors of cardiovascular disease.

27 Oct 2015

Researchers develop multiplexed screening approach to study cancer development in mice

In a novel use of the CRISPR/Cas9 system, which can be deployed to switch genes off, researchers from Germany, the UK and Spain have developed a multiplexed screening approach to study and model cancer development in mice. The scientists mutated genes in the adult mouse liver uncovering their cancer-causing roles and determining which combinations of genes cooperate to cause liver cancer.

27 Oct 2015

FDA approves Yondelis (trabectedin) for treatment of specific soft tissue sarcomas

The U.S. Food and Drug Administration today approved Yondelis (trabectedin), a chemotherapy, for the treatment of specific soft tissue sarcomas (STS) – liposarcoma and leiomyosarcoma – that cannot be removed by surgery (unresectable) or is advanced (metastatic).

24 Oct 2015

Breakthrough research suggests that female sex hormone may save lives on the battlefield

Breakthrough research suggests a female sex hormone may be the key to saving lives on the battlefield, where between 2001 and 2011 more than 80 percent of potentially preventable U.S. war injury deaths resulted from blood loss.

22 Oct 2015

Liver News and Research

Diet missing soluble fiber promotes inflammation in the intestines, leading to weight gain

Discovery may allow physicians to warn patients years before onset of diabetes

Isis Pharmaceuticals begins ISIS-FXI Rx Phase 2 study in patients with ESRD on hemodialysis

Gut bacteria may increase risk of metabolic syndrome

SLU hepatologist receives $150,000 grant to study preventative strategies for TPN-associated disorders

Certain drugs could be used to treat gastric cancers with particular pattern of mutations

Yervoy approved for patients at high risk of developing recurrence of melanoma after surgery

Cancer diagnosis improvements in England: an interview with Lucy Elliss-Brookes

New generation of incretin-based medicines allows coordinated action against diabesity

Hiroshima University researchers report promising new avenue for treating hepatitis B

Researchers uncover genes that can suppress HCV infection within the liver

Watching too much TV increases risk of death

Research provides novel insight into potential new therapeutic targets for triple-negative breast cancer

Praziquantel treatment safe for pregnant women after first trimester

Imlygic approved for treatment of melanoma lesions in the skin and lymph nodes

Reducing sugar intake reverses chronic metabolic diseases in children

Four microRNAs appear to play critical roles in controlling cholesterol, triglyceride metabolism

Researchers develop multiplexed screening approach to study cancer development in mice

FDA approves Yondelis (trabectedin) for treatment of specific soft tissue sarcomas

Breakthrough research suggests that female sex hormone may save lives on the battlefield

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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