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Harmful gut bacteria co-opt a genetic susceptibility to trigger Crohn’s disease

Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn’s disease, according to a new study led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

1 Dec 2022

Fibromuscular dysplasia and abdominal aortic aneurysm have a “shared complex genetic architecture”

One disease is more common in people assigned female at birth, while the other is more common in people assigned male at birth.

1 Dec 2022

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

1 Dec 2022

UTHealth Houston professor wins $3.5 million to study the mechanisms of brain receptors involved in neurological disorders

A five-year, nearly $3.5 million grant to study the mechanisms of brain receptors involved in neurological disorders such as learning disabilities has been awarded to Vasanthi Jayaraman, PhD, of UTHealth Houston by the National Institutes of Health.

1 Dec 2022

Phase 2 clinical trial of DS-1211 begins for individuals with Pseudoxanthoma Elasticum

A Phase 2 clinical trial has started of DS-1211 in individuals with Pseudoxanthoma Elasticum (PXE), a rare multisystem genetic disease that causes calcium deposits in soft tissue resulting in considerable morbidity.

1 Dec 2022

The importance of early cancer screening

In this interview, Thomas Qiu, Senior Product Manager from BGI Genomics, talks to NewsMedical about current global cancer rates, and the importance of early cancer screening.

From BGI Genomics 1 Dec 2022

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

A change in the DNA code (mutation) of a gene that plays a key role in the brain's immune defenses may prevent related cells from clearing away protein-filled clumps, a new study in mice shows.

30 Nov 2022

Grape consumption protects against ultraviolet UV damage to the skin

A recent human study published this week in the scientific journal Antioxidants found that consuming grapes protected against ultraviolet (UV) damage to the skin. Study subjects showed increased resistance to sunburn after consuming 2 ¼ cups of grapes every day for two weeks.

30 Nov 2022

Specific genetic variant linked to early-onset childhood epilepsy discovered

Researchers at Children's Hospital of Philadelphia (CHOP) have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies.

30 Nov 2022

Study shows SARS-CoV-2 VOCs disseminated around the world according to different spatial source-sink dynamics

Researchers assessed the dispersion patterns of SARS-CoV-2 variants and their global expansion.

30 Nov 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

New research out of VCU Massey Cancer Center points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer.

30 Nov 2022

The evolutionary trajectories and mechanisms driving the emergence of post-Omicron SARS-CoV-2 lineages

Researchers summarized the mechanisms through which the SARS-CoV-2 new Omicron sublineages are evolving.

30 Nov 2022

Study identifies risk factors that increase Black men's susceptibility to early-onset prostate cancer

A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study involving Duke Health researchers has found.

29 Nov 2022

Broccoli and sprouts improve gut microbiota and reduce inflammation in IBD

Recently, scientists reviewed the role of sulforaphane from cruciferous vegetables (e.g., broccoli) in preventing IBD by regulating inflammation and altering the gut microbiome.

29 Nov 2022

Understanding the genetics of healthy brain cells to target vulnerabilities in glioblastomas

Understanding how cancer cells evolve from healthy brain cells and evade treatment could open up potential new drug therapies for glioblastomas, one of the most common and lethal brain cancers, new research has revealed.

29 Nov 2022

Study finds possible shared predisposition between migraine and upper extremity nerve compression syndromes

Patients who undergo surgery for carpal tunnel syndrome and other upper extremity nerve compression syndromes are more likely to have a diagnosis of migraine headaches, reports a study in the December issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

29 Nov 2022

Study links MAIT cells to cognitive function

Could the underproduction of poorly understood immune cells contribute to Alzheimer's disease and other forms of cognitive decline? A Rutgers study in Nature Immunology suggests it may – and that increasing these cells could reverse the damage.

29 Nov 2022

Eating healthy plant-based diet linked to reduced risk of colorectal cancer

Eating a plant-based diet rich in healthy plant foods - such as whole grains, vegetables, and legumes - and low in unhealthy plant foods - including refined grains, fruit juices, and added sugars - is associated with a lower risk of colorectal cancer in men.

29 Nov 2022

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Researchers used ribonucleic acid (RNA) sequence data to understand the association between inflammatory cytokines and poor outcomes of pediatric Acute Myeloid Leukemia (pAML).

29 Nov 2022

Genetic News and Research

Harmful gut bacteria co-opt a genetic susceptibility to trigger Crohn’s disease

Fibromuscular dysplasia and abdominal aortic aneurysm have a “shared complex genetic architecture”

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

UTHealth Houston professor wins $3.5 million to study the mechanisms of brain receptors involved in neurological disorders

Phase 2 clinical trial of DS-1211 begins for individuals with Pseudoxanthoma Elasticum

The importance of early cancer screening

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

Grape consumption protects against ultraviolet UV damage to the skin

Specific genetic variant linked to early-onset childhood epilepsy discovered

Study shows SARS-CoV-2 VOCs disseminated around the world according to different spatial source-sink dynamics

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

The evolutionary trajectories and mechanisms driving the emergence of post-Omicron SARS-CoV-2 lineages

Study identifies risk factors that increase Black men's susceptibility to early-onset prostate cancer

Broccoli and sprouts improve gut microbiota and reduce inflammation in IBD

Understanding the genetics of healthy brain cells to target vulnerabilities in glioblastomas

Study finds possible shared predisposition between migraine and upper extremity nerve compression syndromes

Study links MAIT cells to cognitive function

Eating healthy plant-based diet linked to reduced risk of colorectal cancer

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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