Bacterial News and Research

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Newly developed technique can kill antibiotic-resistant germs

Infectious bacteria received a taste of their own medicine from University of Missouri researchers who used viruses to infect and kill colonies of Pseudomonas aeruginosa, common disease-causing bacteria. The viruses, known as bacteriophages, could be used to efficiently sanitize water treatment facilities and may aid in the fight against deadly antibiotic-resistant bacteria.

25 Sep 2012

UCSD bioengineers to play a central role in new NIH program to accelerate metabolomics

With a $6 million grant over five years, bioengineers from the University of California, San Diego will play a central role in a new program from the National Institutes of Health (NIH) to accelerate "metabolomics", an emerging field of biomedical research that offers a path to a wealth of information about a person's nutrition, infection, health, disease status and more.

25 Sep 2012

Lack of cytokeratin 6A may lead to eye infections

Exposed tissue surfaces, including skin and mucous membranes, are under constant threat of attack by microorganisms in the environment. The layer of cells that line these areas, known as epithelial cells, are the first line of defense against these pathogens, but the underlying molecular mechanisms that allow them to repel microbes are unknown.

25 Sep 2012

Chronic respiratory disease treatments: an interview with Dr Sven Jan-Anders Karlsson, CEO of Verona Pharma

There are many different chronic respiratory diseases. Verona Pharma is mainly focused on two diseases: asthma and COPD. Asthma is a very common disease and unfortunately it has been increasing in prevalence in developed countries. This is the same with COPD; however, there may be different reasons for this.

25 Sep 2012

Small fragments of keratin protein in the eye play a key role in warding off pathogens

When it comes to germ-busting power, the eyes have it, according to a discovery by University of California, Berkeley, researchers that could lead to new, inexpensive antimicrobial drugs.

25 Sep 2012

PPI use linked with risk for infection in decompensated cirrhosis

Proton-pump inhibitors are associated with an increased risk for serious infections in patients with decompensated cirrhosis, research shows.

24 Sep 2012

Genomic analysis of E. coli shows multiple steps to evolve new trait

Several years ago researchers at Michigan State University (MSU) reported discovering a novel, evolutionary trait in a long-studied population of Escherichia coli, a rod-shaped bacterium commonly found in the lower intestine of mammals. The E. coli added a helping of citrate to its traditional diet of glucose, even though other E. coli can't consume citrate in the presence of oxygen.

24 Sep 2012

‘Friendly bacteria’ may help prevent sinusitis

Having the right bacteria present in a person’s sinuses might be key to preventing chronic sinusitis, say researchers.

21 Sep 2012

Sweet success healing diabetic foot ulcers

Scientists have harnessed the antibacterial properties of Manuka honey to speed healing of neuropathic diabetic foot ulcers.

20 Sep 2012

GSK3 inhibition protects against gum disease

Treatment with the cell-permeable glycogen synthase kinase -3β-specific enzyme inhibitor SB216763 successfully suppresses alveolar bone loss in mice infected with the main periodontal pathogen, Porphyromonas gingivalis, report researchers.

20 Sep 2012

Study finds identical strains of antibiotic-resistant C. coli in ABF and conventionally raised pigs

Researchers from North Carolina State University have found identical strains of antibiotic-resistant Campylobacter coli (C. coli) in both antibiotic-free (ABF) and conventionally raised pigs.

18 Sep 2012

Prevalence MRSA laryngitis may be underestimated

Methicillin-resistant Staphylococcus aureus laryngitis may be more common than previously suspected, a new case series suggests.

17 Sep 2012

Orthopedists should suspect necrotizing fasciitis in patients with out of proportion pain

Dr. Russell Russo, an Orthopedic Surgeon at LSU Health Sciences Center New Orleans, and other researchers stress that orthopedists should have a high index of suspicion for necrotizing fasciitis, or flesh-eating bacterial infection, in every patient with pain or other symptoms that are out of proportion to the initial diagnosis. Their recommendations are published in the September 2012 issue of Orthopedics Today.

17 Sep 2012

FDA designates Rib-X's delafloxacin as QIDP for acute bacterial skin and skin structure infections

Rib-X Pharmaceuticals, Inc., today announced that the Food and Drug Administration (FDA) designated delafloxacin as a Qualified Infectious Disease Product (QIDP) for the indications of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP).

17 Sep 2012

Natural antibiotic to treat tuberculosis

A natural product secreted by a soil bacterium shows promise as a new drug to treat tuberculosis report scientists in a new study published in EMBO Molecular Medicine. A team of scientists working in Switzerland has shown how pyridomycin, a natural antibiotic produced by the bacterium Dactylosporangium fulvum, works.

17 Sep 2012

Biomedical scientists identify set of genes essential for A. baumannii gram-negative bacteria

Biomedical scientists collaborating on translational research at two Buffalo institutions are reporting the discovery of a novel, and heretofore unrecognized, set of genes essential for the growth of potentially lethal, drug-resistant bacteria.

15 Sep 2012

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

In an advance toward development of a nasal spray that protects against infection with influenza and spread of the disease, scientists are reporting identification of a substance that activates the first-line defense system against infection inside the nose. They describe effects of a synthetic form of a natural substance found in bacterial cell walls in ACS' journal Molecular Pharmaceutics.

13 Sep 2012

Loss of normal microbial diversity may be culprit behind chronic sinusitis

A common bacteria ever-present on the human skin and previously considered harmless, may, in fact, be the culprit behind chronic sinusitis, a painful, recurring swelling of the sinuses that strikes more than one in ten Americans each year, according to a study by scientists at the University of California, San Francisco.

13 Sep 2012

Case Western Reserve researcher discovers new antivirulence drugs against MRSA and strep

Menachem Shoham, PhD, associate professor of biochemistry at Case Western Reserve University School of Medicine, has discovered novel antivirulence drugs that, without killing the bacteria, render Methicillin Resistant Staphylococcus Aureus (MRSA) and Streptococcus pyogenes, commonly referred to as strep, harmless by preventing the production of toxins that cause disease.

13 Sep 2012

Positive data from Tetraphase Pharmaceuticals’ eravacycline Phase 2 trial on cIAI

Tetraphase Pharmaceuticals, Inc., a clinical-stage life science company developing novel antibiotics effective against antibiotic-resistant bacteria, presented new, positive Phase 2 clinical data on its lead drug candidate, eravacycline (TP-434), on September 11, 2012, at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, CA.

13 Sep 2012

Bacterial News and Research

Newly developed technique can kill antibiotic-resistant germs

UCSD bioengineers to play a central role in new NIH program to accelerate metabolomics

Lack of cytokeratin 6A may lead to eye infections

Chronic respiratory disease treatments: an interview with Dr Sven Jan-Anders Karlsson, CEO of Verona Pharma

Small fragments of keratin protein in the eye play a key role in warding off pathogens

PPI use linked with risk for infection in decompensated cirrhosis

Genomic analysis of E. coli shows multiple steps to evolve new trait

‘Friendly bacteria’ may help prevent sinusitis

Sweet success healing diabetic foot ulcers

GSK3 inhibition protects against gum disease

Study finds identical strains of antibiotic-resistant C. coli in ABF and conventionally raised pigs

Prevalence MRSA laryngitis may be underestimated

Orthopedists should suspect necrotizing fasciitis in patients with out of proportion pain

FDA designates Rib-X's delafloxacin as QIDP for acute bacterial skin and skin structure infections

Natural antibiotic to treat tuberculosis

Biomedical scientists identify set of genes essential for A. baumannii gram-negative bacteria

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

Loss of normal microbial diversity may be culprit behind chronic sinusitis

Case Western Reserve researcher discovers new antivirulence drugs against MRSA and strep

Positive data from Tetraphase Pharmaceuticals’ eravacycline Phase 2 trial on cIAI

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