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Study finds high COVID-19 infection rates in pregnant women

The COVID-19 infection rate among pregnant women was estimated to be 70% higher than in similarly aged adults in Washington state, according to a new study published today in American Journal of Obstetrics and Gynecology.

16 Feb 2021

New analysis shows lack of strong evidence to support anorexia nervosa treatment guidelines

New analysis published in The Lancet Psychiatry has shown a lack of strong evidence to support current guidance on psychological therapies for treating anorexia nervosa over expert treatment as usual.

16 Feb 2021

Anti-immigrant vitriol complicates vaccine rollout in Southern states

In eastern Tennessee, doctors have seen firsthand how a hard-line immigration policy can affect the health and well-being of a community.

16 Feb 2021

Elevated Activin A and FLRG levels correlate with worst outcomes in severe COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a "cytokine storm" in hospitalized and ICU patients. Studies have shown that the blockade of cytokine signaling and steroid treatment helps achieve positive outcomes in patients.

15 Feb 2021

Study: Targeted therapy prolongs survival in patients with advanced bladder cancer

In a new study led by researchers at Yale Cancer Center, the drug enfortumab vedotin (EV) significantly prolonged survival as compared with standard chemotherapy in patients with locally advanced or metastatic urothelial carcinoma or bladder cancer, who had previously received platinum-based treatment and a PD-1–PD-L1 inhibitor.

15 Feb 2021

Study broadens the definition of self-injury mortality to encompass most drug overdose deaths

Classifying a death as suicide may be easiest for medical examiners and coroners in the western United States, which reports the highest suicide rates officially. Suicide by firearm is the leading method there, and usually clear in terms of evidence.

15 Feb 2021

How SARS-CoV-2 enters the central nervous system

The central nervous system (CNS) is highly protected in the human body. Yet, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the CNS, causing profound clinical complications. How is the CNS involved in a respiratory virus infection?

15 Feb 2021

Researchers report a new SARS-CoV-2 variant of concern in Uganda

An interdisciplinary research team from Uganda and the UK report the emergence and spread of a new SARS-CoV-2 variant of the A lineage with multiple protein changes throughout the viral genome.

15 Feb 2021

Researchers observe rapid increase of SARS-CoV-2 antibodies in plasma over pandemic's course

Researchers found that neutralizing antibodies against SARS-CoV-2 can increase over time. They observed that samples taken from convalescent plasma in September 2020 would likely have high enough values by July 2021 to protect immunodeficient patients who receive intravenous immunoglobulins as part of their treatment.

15 Feb 2021

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

Scientists from Germany have determined the efficacy of currently used therapeutics in treating newer variants of SARS-CoV-2, including the UK, South Africa, and Brazil variants. Their findings reveal that both B.1.351 and B.1.1.248 variants are able to escape humoral immune responses induced by therapeutic antibodies, vaccinations, or natural SARS-CoV-2 infection.

15 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

A new study examines the associations between immunosuppressive disease-modifying therapies (DMTs) used in MS with adverse outcomes in an international cohort of patients with MS COVID-19.

15 Feb 2021

Only 25% of SARS-CoV-2 infections are detected in the UK: Study

A new preprint research paper posted to the medRxiv server estimates the number of infections that are diagnosed from testing alone as being about a fourth of the total.

15 Feb 2021

SARS-CoV-2's resistance to remdesivir in vitro

A new preprint research paper posted to the bioRxiv server discusses the emergence of mutations in the SARS-CoV-2 virus, allowing it to escape the effects of the most commonly used antiviral drug, remdesivir.

14 Feb 2021

S.D. governor gives state high marks in handling the pandemic. Are they deserved?

Covid-19 has pushed states to adopt unique approaches to protect their residents, but few have garnered as much scrutiny as South Dakota.

12 Feb 2021

Lessons learnt from the annual influenza season

Australian researchers have come up with two key recommendations from studies of the annual influenza season - one highlighting the benefits of antivirals in reducing repeat hospitalisation, and the other to watch for underlying cardiovascular disease.

12 Feb 2021

Statins shown to reduce COVID-19 severity and lower mortality

Much attention has been focused on ways to reduce the deadly exaggeration of normal inflammatory reactions to this pathogen. A new research paper posted to the medRxiv* preprint server describes the alleviation of hyper-inflammatory phenomena following the administration of statins, drugs more widely known for their use in reducing blood cholesterol levels, to patients with COVID-19.

11 Feb 2021

STING activation may be a new approach to reduce graft-versus-host disease

MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD).

11 Feb 2021

Duration of delirium in critically ill patients predicts mortality and disability

Delirium, a form of acute brain dysfunction, is widespread in critically ill patients in lower resourced hospitals, and the duration of delirium predicted both mortality and disability at six months after discharge, according to a study published in PLOS ONE.

11 Feb 2021

Adults with intellectual disabilities are particularly vulnerable to COVID-19, study finds

Researchers at the University of Glasgow and the Manchester Metropolitan University in the U.K. report that adults with intellectual disabilities have a higher risk of being infected with SARS-CoV2. They are also more likely to develop worse outcomes once infected.

11 Feb 2021

Mortality News and Research

Study finds high COVID-19 infection rates in pregnant women

New analysis shows lack of strong evidence to support anorexia nervosa treatment guidelines

Anti-immigrant vitriol complicates vaccine rollout in Southern states

Elevated Activin A and FLRG levels correlate with worst outcomes in severe COVID-19

Study: Targeted therapy prolongs survival in patients with advanced bladder cancer

Study broadens the definition of self-injury mortality to encompass most drug overdose deaths

How SARS-CoV-2 enters the central nervous system

Researchers report a new SARS-CoV-2 variant of concern in Uganda

Researchers observe rapid increase of SARS-CoV-2 antibodies in plasma over pandemic's course

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

Only 25% of SARS-CoV-2 infections are detected in the UK: Study

SARS-CoV-2's resistance to remdesivir in vitro

S.D. governor gives state high marks in handling the pandemic. Are they deserved?

Lessons learnt from the annual influenza season

Statins shown to reduce COVID-19 severity and lower mortality

STING activation may be a new approach to reduce graft-versus-host disease

Duration of delirium in critically ill patients predicts mortality and disability

Adults with intellectual disabilities are particularly vulnerable to COVID-19, study finds

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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