Clostridium News and Research

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Transmission of MRSA and Clostridium difficile through dogs

In a letter to the Editor of the Journal of Hospital Infection, published by Elsevier, S. Lefebvre and J.S. Weese from the University of Guelph in Canada describe a study that investigated whether MRSA and C.difficile could be passed between pet therapy dogs and patients.

7 May 2009

Optimer Pharmaceuticals receives production patent for Fidaxomicin

Optimer Pharmaceuticals, Inc. has announced that the United States Patent and Trademark Office issued a production patent (U.S. Patent No. 7,507,564) covering steps used in the manufacture of fidaxomicin, which is currently in its second Phase 3 clinical trial for the treatment of Clostridium difficile infection, or CDI.

13 Apr 2009

Targeted approach to kill specific disease-causing bacteria in the mouth

Research to develop a narrow-spectrum antibiotic that can target a particular species of bacteria without harming the other "good" bacteria present was described at the Society for General Microbiology meeting at Harrogate today (Thursday April 2).

1 Apr 2009

Doctors identify patients at high risk of Clostridium difficile

Doctors have developed and validated a clinical prediction rule for recurrent Clostridium difficile ( C. difficile ) infection that was simple, reliable and accurate, and can be used to identify high-risk patients most likely to benefit from measures to prevent recurrence.

1 Apr 2009

FDA approves new indication for Wyeth's Tygacil (tigecycline)

Wyeth Pharmaceuticals, a division of Wyeth has announced that the U.S. Food and Drug Administration (FDA) approved Tygacil (tigecycline), for the treatment of adult patients with community-acquired bacterial pneumonia (CABP) caused by susceptible strains of indicated pathogens.

24 Mar 2009

Clostridium difficile infection in primary care

The epidemiology of Clostridium difficile infection (CDI) is changing rapidly and has been marked by a significant increase in incidence and severity.

23 Mar 2009

New botulinum toxin type A (Reloxin) appears to be well tolerated and may help reduce forehead wrinkles

Injections with a new type of botulinum toxin appears to be well tolerated and may help to improve the appearance of moderate to severe forehead lines with no evidence of diminishing treatment response over 13 months, according to a report in the March/April issue of Archives of Facial Plastic Surgery.

16 Mar 2009

Review of hospital infection control strategies

Hand-washing, a clean environment, appropriate infection barriers and early identification of patients at high risk of colonization with a transmissible microorganism remain the essential measures to prevent and control infection.

16 Mar 2009

Scientists debug Clostridium difficile

An international team of scientists, led by Monash University researchers, has uncovered the workings of a superbug that kills elderly hospital patients worldwide - a discovery that has the potential to save lives and health care systems billions of dollars each year.

2 Mar 2009

Study reveals high level of adverse drug reactions in hospitals

In a study of more than 3,000 patients, researchers at the University of Liverpool have found that one in seven admitted to hospital experience adverse drug reactions to medical treatment.

15 Feb 2009

Gene technology to fight Clostridium difficile

Scientists at The University of Nottingham are leading a major European study to unravel the genetic code of one of the most lethal strains of hospital acquired infections.

19 Jan 2009

New nasal spray vaccine shown to be effective against botulism

A preclinical study found a new nasal spray vaccine to provide complete protection against a major botulism toxin, according to a study published today in the Nature journal Gene Therapy .

8 Jan 2009

New report shows high Clostridium difficile infection rates in U.S. hospitals

Consumers Union called on hospitals today to take more aggressive steps to protect patients from Clostridium difficile (C.-diff.) infections in light of a new report showing that they are much more common than previous estimates had indicated. As the rate of hospital acquired C.-diff. infections has jumped in recent years, an increasing number of patients have developed antibiotic-resistant strains of the infection that are more difficult to treat and more deadly.

11 Nov 2008

Phase 2 trial of treatment of C-difficile-associated diarrhea shows promise

Medarex, Inc. and The Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) today announced that a Phase 2 trial of an anti- C. difficile antibody combination treatment in patients with C.

4 Nov 2008

Current hospital tests for Clostridium difficile not accurate enough

Current hospital tests for the bacterium Clostridium difficile (C difficile) are not accurate enough and a new two-stage process should be introduced to avoid misdiagnosis and its consequences.

2 Nov 2008

Targanta Therapeutics presents preclinical data on Oritavancin against Clostridium difficile infection

Targanta Therapeutics Corporation has released the in vivo data from a preclinical study comparing the activity of its antibiotic drug candidate, oritavancin, to vancomycin in a hamster model of Clostridium difficile infection.

26 Oct 2008

Maggots the key to fighting superbugs

Scientists at Swansea University in Wales have discovered that maggots may hold the key to fighting superbugs.

5 Aug 2008

Superbug breakthrough

The week the government's chief medical officer for England, Sir Liam Donaldson, has announced that the NHS aims to create immunisation against two of the most common superbugs, MRSA and Clostridium difficile, within the next decade. But a research team led by University of Sunderland scientists has made a major breakthrough in the fight against a deadly hospital infection which kills tens of thousands of people every year, and it will be available within the next year.

17 Jul 2008

New British consortium to tackle healthcare associated infections

Just over 8% of all hospital inpatients in England develop a healthcare associated infection, with this figure rising to 23% in intensive care units. Preventing and controlling the transmission of infection is a key priority for those involved in healthcare.

16 Jul 2008

Clostridium difficile closes hospital ward

An outbreak of Clostridium difficile (C. difficile) in a Scottish hospital is causing concern despite claims from health authorities that the outbreak is under control.

23 Jun 2008