Malignant News and Research

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Study identifies new therapeutic target against lung adenocarcinoma

The TIMP-1 protein levels in both tissues and blood have been repeatedly associated with a poor prognosis in lung cancers, but its role in this cancer process was, to date, unknown.

12 Sep 2022

Study provides a potential game-changer in assessing treatment response in pancreatic cancer patients

The statistics for pancreatic cancer are sobering. With a five-year survival rate of only 9%, incidence of the most common type, pancreatic ductal adenocarcinoma (PDAC), is growing and projected to be the second cause of cancer deaths by 2030.

8 Sep 2022

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Based on findings from a new study by a Johns Hopkins Medicine-led research team, an effective means of fighting SARS-CoV-2, the virus that causes COVID-19, may be possible that circumvents the problem of waning immunity often observed when current vaccines deal with emerging COVID variants.

8 Sep 2022

Studies show link between OSA and decline in mental processing powers, increased risk of blood clots, cancer

People who suffer from obstructive sleep apnea (OSA) are at an increased risk of cancer, according to a large study presented on Monday at the European Respiratory Society International Congress in Barcelona, Spain.

5 Sep 2022

Depletion of reactive astrocytes regresses glioblastoma

A groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cancer. The researchers achieved the outcome using a method they developed based on their discovery of two critical mechanisms in the brain that support tumor growth and survival: one protects cancer cells from the immune system, while the other supplies the energy required for rapid tumor growth. The work found that both mechanisms are controlled by brain cells called astrocytes, and in their absence, the tumor cells die and are eliminated.

2 Sep 2022

Oncolytic viruses boost the immune capacity to effectively target and destroy cancer cells

The immune system has evolved to safeguard the body from a wildly diverse range of potential threats. Among these are bacterial diseases, including plague, cholera, diphtheria and Lyme disease, and viral contagions such as influenza, Ebola virus and SARS CoV-2.

29 Aug 2022

“Drug factory” implants show promise in eradicating mesothelioma tumors

Rice University and Baylor College of Medicine researchers have shown they can eradicate advanced-stage mesothelioma tumors in mice in just a few days with a treatment combining Rice's cytokine "drug factory" implants and a checkpoint inhibitor drug.

22 Aug 2022

Scientists discover a mechanism used by insects in the development and regeneration of wings

The first mutation of the wingless gene was found by accident in Drosophila in the 1970s, following the observation of flies that did not possess wings, hence its name.

22 Aug 2022

Celebrating 10 Years of Global Research with Breast Cancer Now Tissue Bank

Breast Cancer Now Tissue Bank have just celebrated 10 years of groundbreaking breast cancer research. We spoke to Professor Louise Jones to find out more about this achievement!

22 Aug 2022

Study contributes to better understanding of the changes in kinase activity in renal cell carcinoma

A new research paper was published in Oncotarget on August 4, 2022, entitled, "Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors."

17 Aug 2022

New anti-cancer drug candidate is absorbed through the lymphatic system rather than blood vessels

A team of University of Michigan researchers is developing a new anti-cancer drug that is absorbed through the gut's lymphatic system rather than blood vessels, potentially outmaneuvering the molecular signaling pathways that lead to drug resistance while increasing cancer-fighting ability and reducing side effects.

17 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Study evaluates the tumor-modulatory effects of opsins on melanoma cancer

Melanopsin (OPN4) is a light-sensing protein found in skin and retina cells. A new study conducted at the University of São Paulo (USP) in Brazil suggests that OPN4 can also participate in the development and progression of melanoma, the most aggressive type of skin cancer.

10 Aug 2022

The impact of cold agglutinin syndrome on clinical presentations in COVID-19

Researchers presented two cases to highlight the impact of cold agglutinin syndrome on clinical presentations in COVID-19.

8 Aug 2022

Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

Combining ultrasound and bubbles helps medicines pass through the protective blood-brain barrier and is giving hope for improved treatment of several diseases.

5 Aug 2022

Epigenetic changes prevent iron-associated programmed cell death in leukemia, research shows

The article, published in the journal Redox Biology by the group of Dr. Manel Esteller, shows that epigenetic changes prevent iron-associated programmed cell death in leukemia and show a new target for treatment with experimental drugs.

1 Aug 2022

New glioma drug may represent a paradigm for designing therapeutics exploiting specific DNA repair

A new class of glioma drugs exploits tumors that lack the DNA repair enzyme MGMT; the drugs lead to the generation of cytotoxic DNA and selectively kill tumor cells without the risk of resistance, researchers report.

29 Jul 2022

Analyzing pathological outcomes in single vs multiple architectural distortion on digital breast tomosynthesis

According to ARRS' American Journal of Roentgenology (AJR), for patients with multiple architectural distortion (AD) identified on digital breast tomosynthesis (DBT), biopsy of all areas may be warranted, given the variation of pathologic diagnoses across AD in individual patients.

28 Jul 2022

New 'decoy receptor' molecules inhibit growth of multiple myeloma and diffuse large B cell lymphoma in mice

Researchers at Stanford University have developed "decoy receptor" molecules that inhibit the growth of both multiple myeloma (MM) and diffuse large B cell lymphoma (DLBCL) in mice.

26 Jul 2022

Malignant News and Research

Study identifies new therapeutic target against lung adenocarcinoma

Study provides a potential game-changer in assessing treatment response in pancreatic cancer patients

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Studies show link between OSA and decline in mental processing powers, increased risk of blood clots, cancer

Depletion of reactive astrocytes regresses glioblastoma

Oncolytic viruses boost the immune capacity to effectively target and destroy cancer cells

“Drug factory” implants show promise in eradicating mesothelioma tumors

Scientists discover a mechanism used by insects in the development and regeneration of wings

Celebrating 10 Years of Global Research with Breast Cancer Now Tissue Bank

Study contributes to better understanding of the changes in kinase activity in renal cell carcinoma

New anti-cancer drug candidate is absorbed through the lymphatic system rather than blood vessels

Novel model reveals how genomic instability arises in histologically benign tissue

Study evaluates the tumor-modulatory effects of opsins on melanoma cancer

The impact of cold agglutinin syndrome on clinical presentations in COVID-19

Optically controlled local heat-pulse method manipulates temperature in cells

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

Epigenetic changes prevent iron-associated programmed cell death in leukemia, research shows

New glioma drug may represent a paradigm for designing therapeutics exploiting specific DNA repair

Analyzing pathological outcomes in single vs multiple architectural distortion on digital breast tomosynthesis

New 'decoy receptor' molecules inhibit growth of multiple myeloma and diffuse large B cell lymphoma in mice

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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