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Sonic hedgehog gene maintains normal physiological state and repair process of adult lungs

The whimsically named sonic hedgehog gene, best known for controlling embryonic development, also maintains the normal physiological state and repair process of an adult healthy lung, if damaged, according to new research from the Perelman School of Medicine at the University of Pennsylvania published online this week in Nature in advance of the print edition.

6 Oct 2015

Understanding HCV disease progression rates among PWID

The Hepatitis C virus (HCV) infection is a chronic blood-borne viral infection that affects an estimated 160 million people, or 2-3% of the population world-wide. Alarmingly, chronic HCV infection accounts for one-quarter of the cases of cirrhosis and hepatocellular carcinoma (HCC). If HCV is left untreated, chronic liver disease will occur in 60-70% of the cases, cirrhosis in 5-20% of the cases, and 1-5% will die from decompensated cirrhosis or HCC.

6 Oct 2015

Georgia State University researcher receives $1.35 million federal grant to study effects of emulsifiers

Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.35 million federal grant to study how emulsifiers affect bacteria in the intestinal tract and cause chronic inflammatory diseases in the gut.

6 Oct 2015

Paradigm failure is primary reason for lack of progress in cancer research, says cancer biologist

A recent publication, which received sustained media attention, claimed that most cancers are just “bad luck”. Its authors stated that only about one-third of cancer mutations are caused by known lifestyle or environmental factors.

6 Oct 2015

U.S 2nd Annual Obesity Summit: 35 major U.S. health societies see how they can treat obesity

Representatives from 35 major health and medical organizations including, the American Diabetes Association (ADA), American Medical Association (AMA), American Heart Association (AHA), American Academy of Orthopaedic Surgeons (AAOS), and American Society of Clinical Oncology (ASCO) convened for a second annual summit in Chicago to identify opportunities for collaboration in treating obesity. “The National Obesity Summit on the Provision of Care for the Obese Patient” was hosted by the American Society for Metabolic and Bariatric Surgery (ASMBS).

4 Oct 2015

Calcitonin-gene related peptide antibody inhibition shows migraine prevention promise

TEV-48125, a monoclonal anti-calcitonin-gene related peptide antibody, is well tolerated and effective in the prevention of high-frequency episodic migraine and chronic migraine, findings from two phase IIb studies show.

2 Oct 2015

Researchers discover new way to stop cancer cells from spreading

Researchers at the Francis Crick Institute and the University of Copenhagen have discovered a new way to potentially 'fence in' a tumour and help stop cancer cells spreading, according to a Cancer Research UK funded study published in EMBO Reports today, (Thursday).

1 Oct 2015

OncoGenex meets target enrollment in apatorsen Phase 2 trial

OncoGenex Pharmaceuticals, Inc. announced today that Borealis-2, an investigator-sponsored, randomized Phase 2 trial, has met its target enrollment of 200 patients. Designed to evaluate apatorsen in combination with docetaxel in patients with advanced or metastatic bladder cancer who have disease progression following first-line platinum-based chemotherapy, Borealis-2 is sponsored by Hoosier Oncology Group and is being conducted at 27 sites across the United States.

30 Sep 2015

Leading cancer researchers address eight 'big questions'

Leading cancer researchers address eight of the "big questions" facing the field as part of the inaugural issue of Trends in Cancer, published by Cell Press.

30 Sep 2015

New study identifies inflammatory lung disease as risk factor for insulin resistance, diabetes

Numerous studies have identified obesity and poor diet as risk factors for insulin resistance and diabetes. A new study adds another risk factor to the list: inflammatory lung disease. Published in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, the study reports that inflammation in the lungs is enough to induce the body-wide inflammation that can lead to insulin resistance.

30 Sep 2015

University of Michigan-led team performs first kidney transplants in Ethiopia

A University of Michigan-led team performed the first kidney transplants in Ethiopia last week, after spending more than two years to help establish a transplant center in the African country.

30 Sep 2015

Study raises hope for reducing life-threatening respiratory problems in infants

St. Jude Children's Research Hospital scientists have a lead on reducing life-threatening respiratory problems in infants born to women who develop the liver disorder intrahepatic cholestasis of pregnancy (ICP).

30 Sep 2015

Reducing tumor burden in lung cancer patients with advanced adenocarcinoma

Boehringer Ingelheim today announced at the European Cancer Congress (ECC) in Vienna, Austria, further data to support the efficacy of VARGATEF® (nintedanib*) in combination with docetaxel for the treatment of advanced non-small cell lung cancer (NSCLC) with adenocarcinoma histology

29 Sep 2015

New self-contained device could provide instant results to routine lab tests, accelerate treatment and diagnosis

Researchers at Houston Methodist, along with collaborators at two major Singapore institutions, have developed a lab in a needle device that could provide instant results to routine lab tests, accelerating treatment and diagnosis by days.

29 Sep 2015

Collaborative program aims at reducing cancer burden among Hispanic/Latinos receives grant from NCI

A collaborative program aimed at reducing the burden of cancer among Hispanic/Latinos in San Diego and Imperial counties through research and community outreach has received a $13 million grant from the National Cancer Institute, part of the National Institutes of Health. The five-year grant renews funding for a partnership started in 2008 between San Diego State University and Moores Cancer Center at UC San Diego Health.

29 Sep 2015

Endocrine-disrupting chemical exposure linked to increased risk of diabetes and obesity

Emerging evidence ties endocrine-disrupting chemical exposure to two of the biggest public health threats facing society - diabetes and obesity, according to the executive summary of an upcoming Scientific Statement issued today by the Endocrine Society.

29 Sep 2015

Two-drug combination improves progression-free survival in patients with advanced melanoma

Patients with advanced melanoma skin cancer survive for longer without their disease progressing if they have been treated with a combination of two drugs, nivolumab and ipilimumab, than with either of these drugs alone. New results show that these patients also do better regardless of their age, stage of disease and whether or not they have a cancer-driving mutation in the BRAF gene.

28 Sep 2015

Re-engineering the brain to perceive food differently

Can we make people healthier by tricking the brain into thinking broccoli tastes like chocolate? A group of internationally acclaimed chefs, bench neuroscientists, food scientists and clinical neurologists are confident that they can.

26 Sep 2015

Arteries may be best source for detecting circulating tumor cells

As the field of liquid biopsies for tracking disease progression and therapeutic response heats up, many doctors are looking for ways to apply this approach to their patients.

26 Sep 2015

Research suggests potential drug targets to stop cancer spread

It only takes seconds: one cancerous cell breaks off from a tumor, slips into the bloodstream and quickly lodges elsewhere in the body. These colonizers may bloom into deadly metastatic cancer right away or lie dormant for years, only to trigger a recurrence decades after the primary tumor is removed.

24 Sep 2015

Liver News and Research

Sonic hedgehog gene maintains normal physiological state and repair process of adult lungs

Understanding HCV disease progression rates among PWID

Georgia State University researcher receives $1.35 million federal grant to study effects of emulsifiers

Paradigm failure is primary reason for lack of progress in cancer research, says cancer biologist

U.S 2nd Annual Obesity Summit: 35 major U.S. health societies see how they can treat obesity

Calcitonin-gene related peptide antibody inhibition shows migraine prevention promise

Researchers discover new way to stop cancer cells from spreading

OncoGenex meets target enrollment in apatorsen Phase 2 trial

Leading cancer researchers address eight 'big questions'

New study identifies inflammatory lung disease as risk factor for insulin resistance, diabetes

University of Michigan-led team performs first kidney transplants in Ethiopia

Study raises hope for reducing life-threatening respiratory problems in infants

Reducing tumor burden in lung cancer patients with advanced adenocarcinoma

New self-contained device could provide instant results to routine lab tests, accelerate treatment and diagnosis

Collaborative program aims at reducing cancer burden among Hispanic/Latinos receives grant from NCI

Endocrine-disrupting chemical exposure linked to increased risk of diabetes and obesity

Two-drug combination improves progression-free survival in patients with advanced melanoma

Re-engineering the brain to perceive food differently

Arteries may be best source for detecting circulating tumor cells

Research suggests potential drug targets to stop cancer spread

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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