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A precursor to remdesivir shows therapeutic potential for COVID-19

A new study points to the potential to use the remdesivir precursor, GS-441524, as a treatment choice for COVID-19.

9 Feb 2021

Mortality study combines drug overdose deaths with all suicide rates into a self-injury category

Classifying a death as suicide may be easiest for medical examiners and coroners in the western United States, which reports the highest suicide rates officially.

9 Feb 2021

Researchers look at long-term outcomes of cancer patients diagnosed with COVID-19

Researchers at MUSC Hollings Cancer Center have joined a nationwide study to look at the long-term outcomes of cancer patients who have been diagnosed with COVID-19.

8 Feb 2021

Study: Older adults classified as "prediabetic" seldom progress to full diabetes

Older adults who are classified as having "prediabetes" due to moderately elevated measures of blood sugar usually don't go on to develop full-blown diabetes, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health.

8 Feb 2021

Analysis finds racial and ethnic disparities in the odds of testing positive for COVID-19

An analysis of Kaiser Permanente members in Northern California early in the COVID-19 pandemic found racial and ethnic disparities in the likelihood of testing positive for the coronavirus, but no significant disparities in mortality among those who were hospitalized.

8 Feb 2021

Real-time tool can rapidly predict mortality for patients facing transfer between hospitals

With the aid of sophisticated machine learning, researchers at UPMC and the University of Pittsburgh School of Medicine demonstrated that a tool they developed can rapidly predict mortality for patients facing transfer between hospitals in order to access higher-acuity care.

8 Feb 2021

Researchers identify a new drug target for Ebola, Marburg viruses

Ebola and Marburg are among the most deadly viruses, with mortality rates from these infections ranging from 25% to 90%.

8 Feb 2021

Machine learning can help improve predictions of mortality risk

Researchers at Geisinger have found that a computer algorithm developed using echocardiogram videos of the heart can predict mortality within a year.

8 Feb 2021

Can early use of colchicine reduce COVID-19 mortality?

The COVID-19 pandemic, caused by SARS-CoV-2, has caused well over 2.3 million deaths in a little over a year. A new meta-analysis reports the potential utility of colchicine in treating SARS-CoV-2 infection and forestalling severe and life-threatening inflammation of the lungs and other organs.

8 Feb 2021

Bioengineered ankyrin compounds show high in vitro activity against SARS-CoV-2 mutants

A new study describes the use of DARPin (designed ankyrin repeat proteins) therapeutic agents, each of which contains three different DARPin domains within the same molecule.

8 Feb 2021

SARS-CoV-2 escape mutations identified against monoclonal antibodies and polyclonal immune sera

A recent study describes the experimental selection of SARS-CoV-2 mutants associated with resistance to antibodies, with important implications for vaccine development and therapeutic antibody use.

8 Feb 2021

COVID-19 pandemic and nanotechnology

Writing in the International Journal of Nanomedicine, Professor Dongki Yang, from the Department of Physiology, Gachon University, South Korea, has reviewed the available knowledge on the coronaviruses, current approaches to tackle the newly emerged SARS-CoV-2 infection, and the innovative application of nanotechnology in the COVID-19 pandemic.

8 Feb 2021

Mortality from sudden cardiac arrest is higher in COVID-19 patients

Sudden cardiac arrest is more often fatal in people with COVID-19, a new study shows. Those responsible for the research see the results as a wake-up call for the public and care providers alike.

6 Feb 2021

Novel hybrid device to boost research on metastatic process of breast cancer cells

European researchers are working on a novel hybrid device to better understand the metastatic process of cancer cells travelling from breast to bone and fast screen new drugs against it.

6 Feb 2021

Anticancer drug may reduce mortality and speed up recovery for severe COVID-19 patients

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020.

6 Feb 2021

Comparing death tolls from covid to past wars is fraught

Counting the dead is one of the first, somber steps in reckoning with an event of enormous tragic scope, be it war, a natural disaster or a pandemic.

5 Feb 2021

How does SARS-CoV-2 infect the pancreas?

To understand how SARS-CoV-2 infects the pancreas and investigate its effects, a team of researchers used the human iPSC (induced pluripotent stem cells)-derived pancreatic cultures and analyzed the post-infection cellular and molecular changes.

5 Feb 2021

AI model aids early detection of severe COVID-19 infection in children

Children have been less impacted by COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2) than adults. But some children diagnosed with SARS-CoV-2 have experienced severe illnesses, including Multisystem Inflammatory Syndrome (MIS-C) and respiratory failure; nearly 80% of children with MIS-C become critically ill with a 2 to 4% mortality rate.

5 Feb 2021

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

Natural reinfection with respiratory syncytial virus varies based on antibody response

Researchers at Baylor College of Medicine found that while most individuals responded to respiratory syncytial virus (RSV) natural reinfection with a typical sustained antibody response associated with protection, a few individuals surprisingly responded atypically, not being able to sustain the antibody response, which declined to levels that made the individuals susceptible to RSV reinfection.

5 Feb 2021

Mortality News and Research

A precursor to remdesivir shows therapeutic potential for COVID-19

Mortality study combines drug overdose deaths with all suicide rates into a self-injury category

Researchers look at long-term outcomes of cancer patients diagnosed with COVID-19

Study: Older adults classified as "prediabetic" seldom progress to full diabetes

Analysis finds racial and ethnic disparities in the odds of testing positive for COVID-19

Real-time tool can rapidly predict mortality for patients facing transfer between hospitals

Researchers identify a new drug target for Ebola, Marburg viruses

Machine learning can help improve predictions of mortality risk

Can early use of colchicine reduce COVID-19 mortality?

Bioengineered ankyrin compounds show high in vitro activity against SARS-CoV-2 mutants

SARS-CoV-2 escape mutations identified against monoclonal antibodies and polyclonal immune sera

COVID-19 pandemic and nanotechnology

Mortality from sudden cardiac arrest is higher in COVID-19 patients

Novel hybrid device to boost research on metastatic process of breast cancer cells

Anticancer drug may reduce mortality and speed up recovery for severe COVID-19 patients

Comparing death tolls from covid to past wars is fraught

How does SARS-CoV-2 infect the pancreas?

AI model aids early detection of severe COVID-19 infection in children

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Natural reinfection with respiratory syncytial virus varies based on antibody response

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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