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Chronic alcohol exposure could negatively impact pancreas' ability to absorb vitamin C

Chronic exposure to alcohol interferes with the pancreas' ability to absorb vitamin C, potentially predisposing the body to pancreatitis and other pancreatic diseases, a new study in the American Journal of Physiology—Cell Physiology reports.

12 May 2016

Researchers discover true Diels-Alder enzyme on the Pacific seabed

Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the 'Mona Lisa of chemical reactions' - in a bacterium that lives at the bottom of the Pacific Ocean.

12 May 2016

Air-dried silk protein encapsulation can stabilize blood samples for long periods of time

Researchers at Tufts University have stabilized blood samples for long periods of time without refrigeration and at high temperatures by encapsulating them in air-dried silk protein.

11 May 2016

Researchers agree to test new stem cell gene therapy for Sanfilippo disease in human trial

Scientists in Manchester, who have developed a stem cell gene therapy to reverse a fatal childhood illness, have agreed to work with a new therapeutics company to test it in a human trial.

11 May 2016

Genetic variations that increase PKC alpha activity may influence development of Alzheimer's disease

In Alzheimer's disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons.

11 May 2016

Titanium dioxide nanoparticles can have low-level effects on oxidative stress genes

A nanoparticle commonly used in food, cosmetics, sunscreen and other products can have subtle effects on the activity of genes expressing enzymes that address oxidative stress inside two types of cells.

11 May 2016

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

A promising approach for watching cell signaling processes in their physiological context: Scientists visualize apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time.

11 May 2016

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin system (RAS) that both prevents and reverses some characteristics of diabetic retinopathy in a mouse model.

10 May 2016

Increasing ghrelin levels during hunger can negatively affect decision making capabilities

Never make a decision when you are hungry. The hormone ghrelin - that is released before meals and known to increase appetite - has a negative effect on both decision making and impulse control. Such were the results of a recently conducted study at Sahlgrenska University.

10 May 2016

Pathogen-selective approach to antibiotic development less disruptive to gut microbiome

St. Jude Children's Research Hospital scientists report the first evidence that a pathogen-specific antibiotic was less disruptive to the gut microbiome than broad-spectrum antibiotics.

10 May 2016

New research on epigenetics of lactose intolerance unravels understanding of schizophrenia

A new study on the epigenetics of lactose intolerance may provide an approach to understanding schizophrenia and other complex, serious illnesses

10 May 2016

High-level quantum chemical computations help unravel underlying mechanism of hepatocellular toxicity

Balasubramanian and Basak have recently reported quantum chemical computations that enhance our understanding of mechanisms for the causes of liver toxicity. Hepatocellular carcinoma is one of the most common forms of cancer, and the primary cause has been attributed to liver fibrosis by chemical toxins, which is followed by liver cirrhosis.

9 May 2016

Unlocking cellular trap door may help in finding cures for many diseases

A team of researchers who two years ago announced a "Trojan horse" method of entering a cell without harming it have now found, in effect, the lock to the cellular "trap door."

6 May 2016

Enzyme previously thought beneficial could pose threat to developing embryos

A pair of Oklahoma Medical Research Foundation scientists have discovered that an enzyme previously thought only to be beneficial could, in fact, pose significant danger to developing embryos. The new research could have implications not only for prenatal development but also for treating lymphedema and liver damage resulting from acetaminophen overdose.

5 May 2016

Researchers develop computer model to reveal how antibiotic-resistant microbes develop and spread

Researchers from the Scientific Research Institute of Physical-Chemical Medicine, MIPT, the company M&S Decisions and the research department of Yandex have built a computer model of the interaction between different bacteria, and between bacteria and the gut wall.

5 May 2016

Blend of pulverized natural bone and man-made plastic can create 3D printed replacement bones

To make a good framework for filling in missing bone, mix at least 30 percent pulverized natural bone with some special man-made plastic and create the needed shape with a 3-D printer. That's the recipe for success reported by researchers at The Johns Hopkins University in a paper published April 18 online in ACS Biomaterials Science & Engineering.

5 May 2016

Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis, pointing to a potential new treatment using drugs previously developed for atherosclerosis.

4 May 2016

Researchers develop molecule that binds to GAA enzymes key to progress of Pompe disease

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

4 May 2016

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

The Gutenberg Research College of Johannes Gutenberg University Mainz has chosen to give the 2016 Gutenberg Research Award to American biomedical researcher Dr. Vishva Dixit for his groundbreaking work in the field of programmed cell death.

4 May 2016

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

In a step forward in the push for targeted treatments that can block the specific molecular malfunctions driving cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers have demonstrated how a genetic mutation can drive the most common type of lymphoma as well as melanoma, the deadliest form of skin cancer.

3 May 2016

Enzyme News and Research

Chronic alcohol exposure could negatively impact pancreas' ability to absorb vitamin C

Researchers discover true Diels-Alder enzyme on the Pacific seabed

Air-dried silk protein encapsulation can stabilize blood samples for long periods of time

Researchers agree to test new stem cell gene therapy for Sanfilippo disease in human trial

Genetic variations that increase PKC alpha activity may influence development of Alzheimer's disease

Titanium dioxide nanoparticles can have low-level effects on oxidative stress genes

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Increasing ghrelin levels during hunger can negatively affect decision making capabilities

Pathogen-selective approach to antibiotic development less disruptive to gut microbiome

New research on epigenetics of lactose intolerance unravels understanding of schizophrenia

High-level quantum chemical computations help unravel underlying mechanism of hepatocellular toxicity

Unlocking cellular trap door may help in finding cures for many diseases

Enzyme previously thought beneficial could pose threat to developing embryos

Researchers develop computer model to reveal how antibiotic-resistant microbes develop and spread

Blend of pulverized natural bone and man-made plastic can create 3D printed replacement bones

Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Researchers develop molecule that binds to GAA enzymes key to progress of Pompe disease

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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