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Psychosis, hepatitis C infection are greatest risk factors for mortality in marginalized Vancouver residents

Marginalized residents of Vancouver's Downtown Eastside are dying at more than eight times the national average, and treatable conditions are the greatest risk factors for mortality, researchers at the University of British Columbia have found.

11 Sep 2015

Chronic alcohol consumption disrupts liver molecular circadian clock, leads to alcoholic liver disease

The activity of an organ in the body changes through the day and is governed by its internal clock, also known as a circadian clock. Staying on a circadian schedule is important for health, and disruptions lead to disease.

11 Sep 2015

FGF21 compound in breast milk plays key role in neonatal nutrient absorption, intestinal function

A compound found in breast milk, named fibroblast growth factor 21 (FGF21), plays a key role in neonatal nutrient absorption and intestinal function. FGF21 also contributes to improve newborn growth and metabolic profile.

11 Sep 2015

New DNA analysis may guide personalized management of hepatocellular carcinoma

Detection of small fragments of tumor DNA, known as circulating tumor DNA, in a patient's pre-surgery serum samples predicts early recurrence of hepatocellular carcinoma and may guide treatment, according to a study published in Cellular and Molecular Gastroenterology and Hepatology, the basic and translational science journal of the American Gastroenterological Association.

10 Sep 2015

New trial results show efficacy of novel enzyme-replacement therapy for genetic lipid disorder

Of the more than 50 known lysosomal storage diseases (LSDs)-rare inherited metabolic disorders-only seven can be treated with approved enzyme-replacement therapies.

10 Sep 2015

Liver failure patients may benefit from CSF-1 treatment that aids the immune system to combat infections

Patients with liver failure could benefit from a treatment that helps the immune system to combat infections linked to the condition, research suggests.

10 Sep 2015

ICU-related mortality may explain variations in cancer outcomes

A Scottish population-based study has characterised the incidence of critical illness resulting in admission to an intensive care unit during the first 2 years after a cancer diagnosis.

9 Sep 2015

Riluzole ‘a candidate treatment’ for cerebellar ataxia

Riluzole may be an effective treatment for cerebellar ataxia, say researchers who call for further studies to confirm their findings.

9 Sep 2015

Dietary uptake of microRNAs certainly insufficient to affect physiological functions, reveal ETH biologists

The scientific world was astonished when, in 2011, Chinese researchers claimed to have found evidence suggesting that minute fragments of plant genetic material - so-called microRNA molecules - of rice ingested from food could play a role in regulating physiological processes in the human body. If this is indeed true, it might even be possible to deliberately modify human physiological functions via this route, for instance by incorporating microRNAs into novel functional foods.

9 Sep 2015

New study of DCD liver transplantations finds no significant link between donor age and organ survival

Organ donation after circulatory death (DCD), in which transplant organs are taken from donors after ay period of no blood circulation or oxygenation, is often considered inferior to donation after brain death, in which circulation and oxygenation are maintained until organs are removed for transplantation. Currently, the use of livers from DCD donors remains controversial, particularly with donors with advanced age.

9 Sep 2015

Lund University researchers reveal how the body develops acute pancreatitis

Researchers at Lund University in Sweden may have discovered one of the keys to understanding how the body develops acute pancreatitis. The results offer hope for the development of drugs that specifically target the disease.

8 Sep 2015

AMRA, Pfizer collaborate to assess fat and muscle measurements to predict obesity, diabetes

AMRA announced that they have entered into a unique international collaboration with Pfizer Inc. to investigate the relationship between fat and muscle distribution in the body and metabolic health, including risk factors for conditions such as obesity and diabetes.

8 Sep 2015

Sustainable irrigation strategies could increase health benefits of virgin olive oil

A team of researchers, that includes UPM, have confirmed that a part of the benefits of virgin olive oil is due to minority compounds that can be increased with sustainable irrigation strategies.

7 Sep 2015

Inhibiting key protein involved in glucose production may help in treating type 2 diabetes

Some treatments for type 2 diabetes make the body more sensitive to insulin, the hormone that lowers blood sugar. But new research at Washington University School of Medicine in St. Louis suggests a different strategy: slowing the production of glucose in the liver.

4 Sep 2015

Risk score predicts ACLF risk in chronic HBV patients

A risk score incorporating routinely collected clinical information can identify patients with chronic hepatitis B virus infection at high risk of developing acute-on-chronic liver failure following severe acute exacerbation, research suggests.

3 Sep 2015

Mitochondrial Pyruvate Carrier could potentially be a new drug target to treat diabetes

High blood sugar is a defining characteristic of Type 2 diabetes and the cause of many of the condition's complications, including kidney failure, heart disease, and blindness. Most diabetes medications aim to maintain normal blood sugar (glucose) levels and prevent high blood sugar by controlling insulin.

3 Sep 2015

Imetelstat drug shows promise in treating patients with myelofibrosis

Imetelstat, a novel drug that targets telomerase, has demonstrated potential value in treating patients with myelofibrosis, according to the results of a study published today in the New England Journal of Medicine.

3 Sep 2015

Tobacco-related cancer risks increase among men in China

In China, smoking now causes nearly a quarter of all cancers in adult males. The finding comes from a large study published early online in CANCER, a peer-reviewed journal of the American Cancer Society, as part of a Special Issue on Lung Cancer in China. High uptake rates of cigarette smoking in teenaged males and continued use in adulthood foreshadow even greater tobacco-related cancer risks for the nation.

3 Sep 2015

Inhalation exposure to PM2.5 pollution triggers liver fibrosis

A research team led by Kezhong Zhang, Ph.D., at the Wayne State University School of Medicine's Center for Molecular Medicine and Genetics, has discovered that exposure to air pollution has a direct adverse health effect on the liver and causes liver fibrosis, an illness associated with metabolic disease and liver cancer.

3 Sep 2015

World Hepatitis Summit highlights need to develop national programmes that can eliminate viral hepatitis

Participants at the first-ever World Hepatitis Summit will urge countries to develop national programmes that can ultimately eliminate viral hepatitis as a problem of public health concern.

2 Sep 2015

Liver News and Research

Psychosis, hepatitis C infection are greatest risk factors for mortality in marginalized Vancouver residents

Chronic alcohol consumption disrupts liver molecular circadian clock, leads to alcoholic liver disease

FGF21 compound in breast milk plays key role in neonatal nutrient absorption, intestinal function

New DNA analysis may guide personalized management of hepatocellular carcinoma

New trial results show efficacy of novel enzyme-replacement therapy for genetic lipid disorder

Liver failure patients may benefit from CSF-1 treatment that aids the immune system to combat infections

ICU-related mortality may explain variations in cancer outcomes

Riluzole ‘a candidate treatment’ for cerebellar ataxia

Dietary uptake of microRNAs certainly insufficient to affect physiological functions, reveal ETH biologists

New study of DCD liver transplantations finds no significant link between donor age and organ survival

Lund University researchers reveal how the body develops acute pancreatitis

AMRA, Pfizer collaborate to assess fat and muscle measurements to predict obesity, diabetes

Sustainable irrigation strategies could increase health benefits of virgin olive oil

Inhibiting key protein involved in glucose production may help in treating type 2 diabetes

Risk score predicts ACLF risk in chronic HBV patients

Mitochondrial Pyruvate Carrier could potentially be a new drug target to treat diabetes

Imetelstat drug shows promise in treating patients with myelofibrosis

Tobacco-related cancer risks increase among men in China

Inhalation exposure to PM2.5 pollution triggers liver fibrosis

World Hepatitis Summit highlights need to develop national programmes that can eliminate viral hepatitis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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