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Disrupted micronuclei might play more active role in carcinogenesis, new study finds

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

9 Jul 2013

$Study shows patients’ awareness of own bone health can help prevent future fracture$

Study shows patients’ awareness of own bone health can help prevent future fracture

People over the age of 50 who have suffered a fracture because of a slip or trip play a central role in making sure they get proper care to prevent a future fracture, a new study has found.

9 Jul 2013

Oklahoma Norman campus researchers receive OCAST grants for health research projects

Four University of Oklahoma Norman campus researchers were awarded OCAST grants for health research projects on subjects that range from the development of bone grafts using adult stem cells to the identification of genes to block parasite development in mosquitoes to new drug development pipelines to improvements in limb movement.

9 Jul 2013

Researcher receives $1.58M NIDCR grant to advance research on link between oral bacteria and fetal death

A new four-year, $1.58 million grant from the National Institute of Dental and Craniofacial Research, will allow a Case Western Reserve University School of Dental Medicine researcher to advance her work linking oral bacteria to fetal death.

9 Jul 2013

Study suggests shape of knee can determine need for ACL reconstruction after ACL tear

A study by researchers at Hospital for Special Surgery has provided the first evidence that the shape of a person's knee could be a factor in the decision of whether a patient should undergo anterior cruciate ligament (ACL) reconstruction after an ACL tear.

3 Jul 2013

CTI announces publication of preclinical, clinical data for pacritinib in Drugs of the Future 2013

Cell Therapeutics, Inc. today announced that a comprehensive article summarizing preclinical and clinical data for pacritinib, an oral JAK2/FLT3 inhibitor, authored by Srdan Verstovsek, M.D., Ph.D., et al., was published in the journal Drugs of the Future 2013.

3 Jul 2013

Metastasis can occur when leukocyte and cancer cell fuse to form genetic hybrid

Yale Cancer Center scientists, together with colleagues at the Denver Police Crime Lab and the University of Colorado, have found evidence that a human metastatic tumor can arise when a leukocyte (white blood cell) and a cancer cell fuse to form a genetic hybrid.

3 Jul 2013

ARIAD Pharmaceuticals' Iclusig gets EC marketing authorization for CML and Ph+ ALL treatment

ARIAD Pharmaceuticals, Inc. today announced that the European Commission has granted a marketing authorization for Iclusig (ponatinib) as an orphan medicinal product for two indications.

2 Jul 2013

UCLA researchers introduce gene therapy technique to treat sickle cell disease

Researchers at UCLA's Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research have successfully established the foundation for using hematopoietic (blood-producing) stem cells from the bone marrow of patients with sickle cell disease to treat the disease.

2 Jul 2013

Osteoarthritis associated genes: an interview with Professor Jonathan Tobias, University of Bristol

Joints are lined by articular cartilage, loss of which is one of the hallmarks of osteoarthritis. Articular cartilage is made up of a number of proteins, such as type II collagen. In rare forms of osteoarthritis, one of these structural proteins is defective as a result of a genetic mutation.

2 Jul 2013

Scientists track down origins of fibrosis-promoting cells that scar and destroy organs

Scientists have tracked down and quantified the diverse origins of cells that drive fibrosis, the incurable, runaway wound-healing that scars and ultimately destroys organs such as the lungs, liver and kidneys.

2 Jul 2013

Transplanted bone marrow stem cells in patients with type 2 diabetes reduce insulin use

A study carried out in India examining the safety and efficacy of self-donated (autologous), transplanted bone marrow stem cells in patients with type 2 diabetes (TD2M), has found that patients receiving the transplants, when compared to a control group of TD2M patients who did not receive transplantation, required less insulin post-transplantation.

30 Jun 2013

Brisdelle receives FDA approval to treat hot flashes associated with menopause

The U.S. Food and Drug Administration today approved Brisdelle (paroxetine) to treat moderate to severe hot flashes (vasomotor symptoms) associated with menopause. Brisdelle, which contains the selective serotonin reuptake inhibitor paroxetine mesylate, is currently the only non-hormonal treatment for hot flashes approved by the FDA.

29 Jun 2013

$Higher levels of Omega-3 fatty acids may reduce risk for hip fractures in postmenopausal women$

Higher levels of Omega-3 fatty acids may reduce risk for hip fractures in postmenopausal women

Higher levels of omega-3 fatty acids in the blood may reduce the risk for hip fractures in postmenopausal women, recent research suggests.

28 Jun 2013

Curing type 1 diabetes: an interview with Dr. Habib Zaghouani, MU School of Medicine

Type 1 diabetes is an attack by the immune system of the islet of Langerhans within the pancreas. Basically, the islet of Langerhans harbor beta cells, which produce insulin and when the islets are attacked, the beta cells destruct and there is no more insulin. When the insulin level goes low, blood glucose levels go high and that creates a problem.

28 Jun 2013

FDA approves Novartis' Exelon Patch for treatment of severe Alzheimer's disease

The US Food and Drug Administration has expanded the approved indication for Exelon Patch (rivastigmine transdermal system) to include the treatment of people with severe Alzheimer's disease with Exelon Patch 13.3mg/24h.

28 Jun 2013

Poor, less educated patients are less likely to receive opioid pain medications in emergency rooms

Patients in moderate to severe pain in emergency rooms across the U.S. are less likely to receive opioid pain medications if they are black, Hispanic, poor, or have less education, compared to more affluent patients, according to a University of Rochester Medical Center study reported in the Journal of General Internal Medicine.

27 Jun 2013

Children with congenital heart disease require higher levels of Vitamin D intake prior to surgery

Until now, there has been no research dedicated to the importance of Vitamin D supplementation in children with congenital heart disease (CHD). However, over the past few years, researchers at the Children's Hospital of Eastern Ontario (CHEO) Research Institute and Cardiovascular Surgery Program teamed with the Canadian Critical Care Trials Group to understand the impact of cardiac surgery on the Vitamin D status of infants and children, to be printed next month in Anesthesiology.

27 Jun 2013

Researchers to use $6.3M grant to develop novel therapeutic approaches for pediatric sarcomas

Researchers at Nationwide Children's Hospital will use a $6.3 million grant to further their study of pediatric sarcomas, a rare form of the disease that affects bone or soft tissue and accounts for 11 percent of all childhood cancers.

27 Jun 2013

Pretreatment PET staging of LS-SCLC associated with improved survival

Each year, 13 percent of all newly diagnosed lung cancer patients are diagnosed with small-cell lung cancer (SCLC). Approximately 39 percent of patients with SCLC are diagnosed with limited-stage disease, meaning the cancer is only present in one lung, but may have spread to lymph nodes or tissue between the lungs.

26 Jun 2013

Bone News and Research

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

Study shows patients’ awareness of own bone health can help prevent future fracture

Oklahoma Norman campus researchers receive OCAST grants for health research projects

Researcher receives $1.58M NIDCR grant to advance research on link between oral bacteria and fetal death

Study suggests shape of knee can determine need for ACL reconstruction after ACL tear

CTI announces publication of preclinical, clinical data for pacritinib in Drugs of the Future 2013

Metastasis can occur when leukocyte and cancer cell fuse to form genetic hybrid

ARIAD Pharmaceuticals' Iclusig gets EC marketing authorization for CML and Ph+ ALL treatment

UCLA researchers introduce gene therapy technique to treat sickle cell disease

Osteoarthritis associated genes: an interview with Professor Jonathan Tobias, University of Bristol

Scientists track down origins of fibrosis-promoting cells that scar and destroy organs

Transplanted bone marrow stem cells in patients with type 2 diabetes reduce insulin use

Brisdelle receives FDA approval to treat hot flashes associated with menopause

Higher levels of Omega-3 fatty acids may reduce risk for hip fractures in postmenopausal women

Curing type 1 diabetes: an interview with Dr. Habib Zaghouani, MU School of Medicine

FDA approves Novartis' Exelon Patch for treatment of severe Alzheimer's disease

Poor, less educated patients are less likely to receive opioid pain medications in emergency rooms

Children with congenital heart disease require higher levels of Vitamin D intake prior to surgery

Researchers to use $6.3M grant to develop novel therapeutic approaches for pediatric sarcomas

Pretreatment PET staging of LS-SCLC associated with improved survival

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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