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Study reveals TBX20 as a vital regulator of direct human cardiac reprogramming

Mammalian hearts have almost no ability to grow new heart muscle cells, called cardiomyocytes, after birth. Thus, dead tissue after an adult heart attack is not repaired with new cardiomyocytes.

21 Oct 2022

Surprising discovery in people of Polynesian ancestry offers clues to genetic underpinnings of high cholesterol

The discovery of a genetic variant that is relatively common among people of Polynesian ancestry, but incredibly rare in most other populations, is giving clues to the genetic underpinnings of high cholesterol in all people, according to new research led by University of Pittsburgh School of Public Health geneticists in partnership with several other groups, including the University of Otago and the Samoan health research community.

21 Oct 2022

MTCH2 acts as a doorway for proteins into the mitochondrial membrane, study reveals

Mitochondria - the organelles responsible for energy production in human cells - were once free-living organisms that found their way into early eukaryotic cells over a billion years ago.

20 Oct 2022

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

In a recent study published in the journal Nature Cell Biology, researchers demonstrated the susceptibility of salivary glands to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in vitro using an organoid culture model.

20 Oct 2022

Multiomics analysis identifies immunobiomarkers for COVID-19 severity in outpatients

In a recent study published in the journal eLife, researchers showed the utility of machine-learning models in identifying early immune signatures, which could reliably predict clinical and immunological outcomes in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected outpatients.

20 Oct 2022

Infancy acid suppression and antibiotic use are associated with celiac disease

Researchers determine whether exposure to certain prescriptions after the first six months of life was associated with a diagnosis of celiac disease.

20 Oct 2022

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

A team led by scientists at Scripps Research and the University of Amsterdam has achieved an important goal in virology: mapping, at high resolution, critical proteins that stud the surface of the Hepatitis C virus (HCV) and enable it to enter host cells.

20 Oct 2022

Male mice three times more likely than females to survive E. coli infection

Scientists at UC San Francisco have developed a new way of looking at sex-biased diseases that is rooted in evolutionary biology.

20 Oct 2022

TDP-43 can be useful biomarker for identifying neuropathological subtypes of frontotemporal dementia

Frontotemporal dementia (FTD) is one of the most common causes of progressive dementia in working-age people.

20 Oct 2022

Researchers circumvent a key mechanism in castration-resistant prostate cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that they can circumvent a key mechanism in castration-resistant prostate cancer (CRPC) and possibly make immunotherapies more effective.

20 Oct 2022

Breakthrough infection risk and immune responses to vaccines associated with human leukocyte antigen alleles

Researchers from the U.K. used data from clinical trials of the Oxford-AstraZeneca COVID-19 vaccine ChAdOx1 nCoV-19 to understand the genetic factors contributing to the individual variations in the antibody responses to the vaccine.

20 Oct 2022

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

In a recent study posted to the bioRxiv* preprint server, researchers at Ohio State University and the University of Texas Medical Branch assessed the underlying mechanisms involved in the fusogenicity and endosomal entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

20 Oct 2022

Scientists develop new tool to monitor brain plasticity

Scientists at Scripps Research have developed a new tool to monitor brain plasticity - the way our brains remodel and physically adapt as we learn and experience things, from watching a movie to learning a new song or language.

19 Oct 2022

Antibodies can prevent surface proteins of bacteria from entering host cells

Using bacteria of the Bartonella henselae species, researchers from Goethe University, Frankfurt University Hospital, the Paul Ehrlich Federal Institute for Vaccines and Biomedicines in Langen, and the University of Oslo demonstrated for the first time that antibodies can prevent certain surface proteins of bacterial pathogens from entering host cells.

19 Oct 2022

Rare insect-eating mushrooms show potential to develop new anti-viral and cancer medications

Scientists studying the medicinal potential of a rare insect-eating mushroom have found a way to grow the elusive fungi in the lab, opening the way for the development of new anti-viral and cancer medications.

19 Oct 2022

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19).

19 Oct 2022

What is the risk of severe COVID-19 in infants younger than three months?

Researchers from Italy investigated the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in infants younger than three months and compared the reported coronavirus disease 2019 (COVID-19) severity scores for the pediatric population.

19 Oct 2022

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

A recent study under review at the journal Scientific Reports and currently available on the Research Square* preprint server reported the development of a robust pipeline for fabricating an mRNA vaccine portfolio to combat current and future coronavirus outbreaks, other infectious diseases, and cancer.

19 Oct 2022

Adaptation-proof SARS-CoV-2 vaccine design is one step closer to reality

A vaccine design approach that could protect against new variants of SARS-CoV-2, the virus that causes COVID-19, but also potentially protects against other coronaviruses is one step closer to reality as a result of Penn State College of Medicine research.

18 Oct 2022

Protein C News and Research

Study reveals TBX20 as a vital regulator of direct human cardiac reprogramming

Surprising discovery in people of Polynesian ancestry offers clues to genetic underpinnings of high cholesterol

MTCH2 acts as a doorway for proteins into the mitochondrial membrane, study reveals

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

Multiomics analysis identifies immunobiomarkers for COVID-19 severity in outpatients

Infancy acid suppression and antibiotic use are associated with celiac disease

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

Male mice three times more likely than females to survive E. coli infection

TDP-43 can be useful biomarker for identifying neuropathological subtypes of frontotemporal dementia

Researchers circumvent a key mechanism in castration-resistant prostate cancer

Breakthrough infection risk and immune responses to vaccines associated with human leukocyte antigen alleles

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

Scientists develop new tool to monitor brain plasticity

Antibodies can prevent surface proteins of bacteria from entering host cells

Rare insect-eating mushrooms show potential to develop new anti-viral and cancer medications

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

What is the risk of severe COVID-19 in infants younger than three months?

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

Adaptation-proof SARS-CoV-2 vaccine design is one step closer to reality

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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