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Certain gastrointestinal types of GVHD are associated with worsened quality of life and death

Joseph Pidala, M.D., M.S., assistant member of the Blood and Bone Marrow Transplant and Immunology programs at Moffitt Cancer Center, and colleagues from the Chronic Graft-Versus-Host Disease Consortium have determined that certain gastrointestinal and liver-related types of chronic graft-versus-host disease (GVHD) are associated with worsened quality of life and death.

18 Jun 2013

New study identifies possible treatment to block deposition of calcium in arterial wall

HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important for the integrity and function of the envelope surrounding the cell nucleus. The mutation causes incorrect processing of the messenger RNA for lamin proteins, resulting in the synthesis of an anomalous protein, called progerin.

18 Jun 2013

Bazedoxifene used for treating osteoporosis stops growth of breast cancer cells

A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study.

17 Jun 2013

European Commission amends marketing authorisation for Celgene's REVLIMID

Celgene International Sàrl was today notified that the European Commission has amended the marketing authorisation for REVLIMID. This decision means that REVLIMID is now approved to treat patients with transfusion-dependent anaemia due to low or intermediate-1 risk myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality when other therapeutic options are insufficient or inadequate.

17 Jun 2013

Mount Sinai researchers present several new studies at ENDO 2013

Researchers from the Icahn School of Medicine at Mount Sinai will present several new studies at ENDO 2013, The Endocrine Society's Annual Meeting & Expo from June 15-18 in San Francisco.

17 Jun 2013

$Study: Older patients will make positive lifestyle changes to avoid risk of fractures$

Study: Older patients will make positive lifestyle changes to avoid risk of fractures

Older patients who know they are at risk of fractures will make positive lifestyle changes to avoid them, such as exercising, wearing proper footwear and taking supplements, a new study has found.

16 Jun 2013

Study shows patients with avascular necrosis have turned to stem cell therapy for aid

Stem cells have long been touted as the next big thing. Well just maybe, it is here. According to Dr. Dennis Lox, some patients with a disorder of the bone called avascular necrosis (AVN), have turned to stem cell therapy for aid.

15 Jun 2013

Dosimetry based on 3-D medical images estimates possible dose for targeted RIT in blood cancer patients

Outcomes can be bleak for non-Hodgkin lymphoma (NHL), a cancer that develops in the white blood cells of the immune system. Accurate estimation of radiation absorbed dose in radioimmunotherapy (RIT) based on state-of-the-art 3D imaging could lead to more personalized and effective treatments to improve patients' chances of living longer without progression of their cancer, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting.

15 Jun 2013

Comparison of 1,000-year-old and modern bacterial genomes provides insights into history of leprosy pathogen

From skeletons and biopsies, an international team of scientists was successful in reconstructing a dozen medieval and modern genomes of the leprosy-causing bacteria Mycobacterium leprae.

15 Jun 2013

Anatomy of a Hospital: New book chronicles history of nation's oldest hospital for orthopedics

With 537 pages and 150 photographs, "Anatomy of a Hospital" chronicles the history of the nation's oldest hospital for orthopedics, from its beginnings in a doctor's home to help destitute children with disabilities to the premier hospital it has become today.

15 Jun 2013

Osseon releases Osseoflex CD-H hydraulic cement delivery system

Osseon announces the release of the Osseoflex CD-H hydraulic cement delivery system. This latest addition to the Osseon product line is designed for delivery of medium to high viscosity bone cement during the treatment of vertebral compression fractures.

14 Jun 2013

Study offers hope for development of novel treatments for stroke, neurological diseases

A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers.

14 Jun 2013

Xgeva receives FDA approval for treating giant cell tumor of the bone

The U.S. Food and Drug Administration today expanded the approved use of Xgeva (denosumab) to treat adults and some adolescents with giant cell tumor of the bone, a rare and usually non-cancerous tumor.

14 Jun 2013

Researchers identify biochemical pathway that links nail growth to fingertip regeneration

Mammals possess the remarkable ability to regenerate a lost fingertip, including the nail, nerves and even bone. In humans, an amputated fingertip can sprout back in as little as two months, a phenomenon that has remained poorly understood until now. In a paper published today in the journal Nature, researchers at NYU Langone Medical Center shed light on this rare regenerative power in mammals, using genetically engineered mice to document for the first time the biochemical chain of events that unfolds in the wake of a fingertip amputation.

13 Jun 2013

New study shows treatment with brodalumab demonstrates clinical response in subjects with PsA

A new study presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism, shows that treatment with brodalumab demonstrates significant clinical response and an acceptable safety profile in subjects with psoriatic arthritis.

13 Jun 2013

Bacterium that causes gum disease delivers one-two punch by triggering protective proteins in oral cavity

The newly discovered bacterium that causes gum disease delivers a one-two punch by also triggering normally protective proteins in the mouth to actually destroy more bone, a University of Michigan study found.

12 Jun 2013

Researchers discover TTC7A gene that causes multiple intestinal atresia in newborns

Physicians and researchers from Sherbrooke, Montreal and Quebec City have conducted a study that has led to the discovery of a gene that causes multiple intestinal atresia (MIA), a rare and life-threatening hereditary disorder that affects newborns.

12 Jun 2013

Study reveals radioimmunotherapy can improve survival rates of patients with aggressive lymphoma

A new patient protocol for aggressive and recurrent lymphoma that combines intensive chemotherapy and radioimmunotherapy (RIT) may become the most powerful cancer-killing therapy available, with the hope that patients' lymphoma can be eradicated as they prepare for bone marrow transplant, say researchers at the 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

12 Jun 2013

New imaging system combines PET and MR for mapping recurrent prostate cancer

When prostate cancer makes a comeback, it becomes increasingly important to have exceptional imaging available to find all possible regions where cancer has spread to other parts of the body, or metastasized, in order to plan the best possible treatment.

12 Jun 2013

RTI Biologics intents to acquire privately held Pioneer Surgical Technology

RTI Biologics Inc., a leading provider of orthopedic and other biologic implants, announced today its intent to acquire privately held Pioneer Surgical Technology, headquartered in Marquette, Mich.

12 Jun 2013

Bone News and Research

Certain gastrointestinal types of GVHD are associated with worsened quality of life and death

New study identifies possible treatment to block deposition of calcium in arterial wall

Bazedoxifene used for treating osteoporosis stops growth of breast cancer cells

European Commission amends marketing authorisation for Celgene's REVLIMID

Mount Sinai researchers present several new studies at ENDO 2013

Study: Older patients will make positive lifestyle changes to avoid risk of fractures

Study shows patients with avascular necrosis have turned to stem cell therapy for aid

Dosimetry based on 3-D medical images estimates possible dose for targeted RIT in blood cancer patients

Comparison of 1,000-year-old and modern bacterial genomes provides insights into history of leprosy pathogen

Anatomy of a Hospital: New book chronicles history of nation's oldest hospital for orthopedics

Osseon releases Osseoflex CD-H hydraulic cement delivery system

Study offers hope for development of novel treatments for stroke, neurological diseases

Xgeva receives FDA approval for treating giant cell tumor of the bone

Researchers identify biochemical pathway that links nail growth to fingertip regeneration

New study shows treatment with brodalumab demonstrates clinical response in subjects with PsA

Bacterium that causes gum disease delivers one-two punch by triggering protective proteins in oral cavity

Researchers discover TTC7A gene that causes multiple intestinal atresia in newborns

Study reveals radioimmunotherapy can improve survival rates of patients with aggressive lymphoma

New imaging system combines PET and MR for mapping recurrent prostate cancer

RTI Biologics intents to acquire privately held Pioneer Surgical Technology

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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