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Study finds direct link between birth outcomes and placental oxygen transport

When a baby is born small, it's often attributed to genetic factors or maternal risk factors like poor nutrition or smoking.

16 Jun 2017

Near-atomic resolution 3D snapshots show how key biological machine unfolds problematic proteins

Hand over hand. That's how new, near-atomic resolution, 3-D snapshots show that a key biological machine unfolds a ribbon of protein through its central channel.

16 Jun 2017

Researchers shed light on underlying reasons for eye-avoidance by individuals with ASD

Individuals with autism spectrum disorder (ASD) often find it difficult to look others in the eyes. This avoidance has typically been interpreted as a sign of social and personal indifference, but reports from people with autism suggests otherwise.

16 Jun 2017

Early life stress encodes lifelong susceptibility to depression through alterations in brain reward region

Early life stress encodes lifelong susceptibility to stress through long-lasting transcriptional programming in a brain reward region implicated in mood and depression, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 15 in the journal Science.

15 Jun 2017

Penn study reveals new molecular pilot light required to turn on brown fat furnace

As we bask in the summer heat, it is easy to take for granted that humans are also prepared for the cold of winter, with overcoats in the closet and home heating systems ready to be fired up as an added assurance against falling temperatures.

15 Jun 2017

Scientists show how brain circuits govern hunger and cravings

The urge to satisfy hunger is a primal one, but – as any dieter knows – choices about when and what to eat can be influenced by cues in the environment, not just how long it's been since breakfast.

14 Jun 2017

Peer-led self-management programs have little impact on quality of life of adolescents with asthma

A study from the University of Warwick suggests peer-led self-management programs have little impact on the quality of life or lung function of adolescents with asthma.

14 Jun 2017

Scientists uncover mechanism that directly links inflammation to mental illness

Up to 75 percent of patients with systemic lupus erythematosus -- an incurable autoimmune disease commonly known as lupus -- experience neuropsychiatric symptoms.

14 Jun 2017

Researchers explore impact of hair products on breast cancer risk

Can use of hair products have an impact on breast cancer risk for women? That is a question explored by Rutgers University investigators – and colleagues from Roswell Park Cancer Institute, Massachusetts General Hospital and Moffitt Cancer Center.

14 Jun 2017

Study shows how RNA splicing errors may trigger development of ALS, FTD

The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)- rare and related neurological disorders marked by progressive deterioration of motor or cognitive abilities- may be due to errors in RNA splicing, an intermediary step for translating genetic instructions into functional proteins.

14 Jun 2017

Researchers find molecule that darkens skin without UV exposure and may protect against skin cancer

A study published in the journal Cell on June 13 has found that a class of small molecules can successfully penetrate and darken human skin samples. The drug developed in the laboratory by researchers in Boston also generates protective tans in red-haired mice.

14 Jun 2017

Study emphasizes importance of molecule in maintaining balanced immune system in the gut

A healthy gut requires a molecule called gp96 to train the immune system to tolerate food and normal microbes, report researchers at the Medical University of South Carolina in the May 19, 2017 issue of Scientific Reports.

14 Jun 2017

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Older adults with elevated levels of brain-clogging plaques -- but otherwise normal cognition -- experience faster mental decline suggestive of Alzheimer's disease, according to a new study led by the Keck School of Medicine of USC that looked at 10 years of data.

13 Jun 2017

Study: CT angiography better predicts risk for future cardiac events in patients with stable chest pain

An analysis of diagnostic test results from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial - in which patients with stable chest pain were randomized to either anatomic or functional testing as an initial diagnostic strategy - showed that the presence and extent of coronary artery disease detected by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.

13 Jun 2017

Low levels of vitamin A could be strong risk factor for TB

People with low levels of vitamin A living with individuals sick with tuberculosis may be 10 times more likely to develop the disease than people with high levels of the nutrient, according to research led by investigators at Harvard Medical School.

13 Jun 2017

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

An analysis of data from five major studies of testicular cancer has identified new genetic locations that could be susceptible to inherited testicular germ cell tumors.

12 Jun 2017

Irregular patterns of sleep and wakefulness linked to lower grades among college students

Previous research has analyzed variations in sleep patterns including number of hours slept, quality of sleep, and sleep-wake times, and found an association with cognitive impairments, health and performance; however, few studies have considered or accurately quantified the effects of regular sleep patterns.

12 Jun 2017

Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes

Interim results from a FDA-approved clinical trial testing the generic vaccine bacillus Calmette-Guérin (BCG) to reverse advanced type 1 diabetes are being presented at the 75th Scientific Sessions of the American Diabetes Association.

12 Jun 2017

Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions

Researchers and clinicians at Joslin Diabetes Center have established a Center for Cell-Based Therapy for Diabetes, the goal of which is to lead the development and translation of cell-based interventions to treat and cure diabetes and its complications.

9 Jun 2017

New research design offers way to assess safety of approved drugs

As the pace of drug approvals accelerates and the U.S. Food and Drug Administration faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their use.

9 Jun 2017

Medical School News and Research

Study finds direct link between birth outcomes and placental oxygen transport

Near-atomic resolution 3D snapshots show how key biological machine unfolds problematic proteins

Researchers shed light on underlying reasons for eye-avoidance by individuals with ASD

Early life stress encodes lifelong susceptibility to depression through alterations in brain reward region

Penn study reveals new molecular pilot light required to turn on brown fat furnace

Scientists show how brain circuits govern hunger and cravings

Peer-led self-management programs have little impact on quality of life of adolescents with asthma

Scientists uncover mechanism that directly links inflammation to mental illness

Researchers explore impact of hair products on breast cancer risk

Study shows how RNA splicing errors may trigger development of ALS, FTD

Researchers find molecule that darkens skin without UV exposure and may protect against skin cancer

Study emphasizes importance of molecule in maintaining balanced immune system in the gut

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Study: CT angiography better predicts risk for future cardiac events in patients with stable chest pain

Low levels of vitamin A could be strong risk factor for TB

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

Irregular patterns of sleep and wakefulness linked to lower grades among college students

Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes

Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions

New research design offers way to assess safety of approved drugs

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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