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New blood test may potentially facilitate detection of Alzheimer's disease at early stage

Today, Alzheimer's disease is diagnosed too late. In collaboration with a research team at the university and German Center for Neurogenerative Diseases in Göttingen, Researchers at Ruhr-Universität Bochum have developed a blood test that may potentially facilitate detection of Alzheimer's at an early stage. It is based on an immuno-chemical analysis using an infrared sensor.

15 Mar 2016

Researchers find new innate immunity pathway that protects mammals from viral oncogenesis

Building upon earlier research, investigators at UT Southwestern Medical Center and their collaborators have identified a new innate immunity pathway that protects mammals from viral oncogenesis, the process by which viruses cause normal cells to become cancerous.

14 Mar 2016

NIH-funded investigators develop therapeutic compound effective against malaria

An international team that includes NIH-funded researchers at Stanford University has developed a therapeutic compound that is effective in inhibiting Plasmodium falciparum, one of five species of parasite that infects people with malaria, and the strain which causes the highest number of malaria deaths.

13 Mar 2016

PKM2 enzyme plays major role in early steps of wound healing

An enzyme involved in glucose metabolism in cells plays a major role in the early steps of wound healing, a finding that could lead to new therapeutic approaches for wound care, according to researchers at Georgia State University.

11 Mar 2016

Southampton researchers explore ADAM33 gene's association with asthma, airway 'twitchiness'

Researchers at the University of Southampton are to study why some people are more likely to develop asthma.

11 Mar 2016

Scientists sort out mechanism of Alzheimer's disease development

A group of the Lomonosov Moscow State University scientists, together with their colleagues from the Institute of Molecular Biology, Russian Academy of Sciences and the King's College London, succeeded in sorting out the mechanism of Alzheimer's disease development and possibly distinguished its key trigger.

11 Mar 2016

Researchers develop molecule that can inhibit enzyme associated with onset of stroke

Research teams separated by 14 hours and 9,000 miles have collaborated to advance prospective treatment for the world's second-leading cause of death.

11 Mar 2016

CYP3A7 gene may over-activate metabolism, reduce effectiveness of cancer treatments

Some patients with breast cancer, lung cancer and leukaemia seem to fare poorly after treatment because of the effects of a particular gene, a new study finds.

10 Mar 2016

Specific gene mutation may significantly reduce risk of heart attack

People with a specific gene mutation have a 50 percent lower risk of suffering a heart attack. This is what an international team of researchers headed by the cardiologist Prof. Heribert Schunkert, Medical Director of the German Heart Center at the Technical University of Munich (TUM), discovered in a broad comparative study. If this gene were switched off with medications it could reduce the risk of coronary disease significantly.

10 Mar 2016

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.

10 Mar 2016

Tailored new compound can dramatically reduce brain damage resulting from stroke

After suffering a stroke, about three-fourths of patients exhibit some disability. The extent of a patient's symptoms depends on the degree and location of brain tissue damage following the stroke event. This week in ACS Central Science, researchers show that by using a tailored small molecule to turn off the production of a key neuromodulator in the brain, they can dramatically reduce brain damage in stroke models in rats.

10 Mar 2016

TSRI researchers uncover new molecular mechanism underlying neurodegenerative diseases

A new study led by scientists at The Scripps Research Institute suggests that cells construct protein "clumps" to protect against neurodegenerative diseases such as amyotrophic lateral sclerosis, a.k.a. ALS or Lou Gehrig's disease.

10 Mar 2016

Study reveals direct regulatory role of serotonin in rheumatoid arthritis

For the first time, serotonin (5-hydroxytryptamine, 5-HT) has been directly implicated in the pathophysiology of rheumatoid arthritis (RA). Although 5-HT is predominantly known as a neurotransmitter within the central nervous system, new evidence points to additional important functions for serotonin in the periphery.

10 Mar 2016

Discovery may provide potential target for new therapies to treat bipolar disorder

Bipolar disorder, which affects nearly eight million Americans, takes a toll not only on patients, but also on their families and communities.

10 Mar 2016

Consuming green tea with dietary iron may lessen health benefits of green tea

Green tea is touted for its many health benefits as a powerful antioxidant, but experiments in a laboratory mouse model of inflammatory bowel disease suggest that consuming green tea along with dietary iron may actually lessen green tea's benefits.

9 Mar 2016

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Researchers observe protection against obesity and insulin resistance but at the cost of prominent fatty liver disease in mice lacking the PEMT enzyme and patients with low levels of PEMT.

7 Mar 2016

Study on DNA scrunching may aid in developing new antimicrobial medicines

A research collaboration that combines novel "big-data" informatics tools with expertise in basic biology has uncovered details of an essential process in life: how a crucial enzyme locates the site on DNA where it begins to direct the synthesis of RNA. This finding may aid in the discovery of new antimicrobial medicines, and the powerful technological approaches developed for this research may shed light on other essential cellular processes.

4 Mar 2016

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.

4 Mar 2016

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

A protein modified to increase the amount of time it circulates in the bloodstream appears to reverse liver fibrosis and cirrhosis in rats, according to results of a study led by Johns Hopkins researchers.

3 Mar 2016

Newly developed process improves efficiency of CRISPR gene editing technology

Scientists have developed a process that improves the efficiency of CRISPR, an up-and-coming technology used to edit DNA.

3 Mar 2016

Enzyme News and Research

New blood test may potentially facilitate detection of Alzheimer's disease at early stage

Researchers find new innate immunity pathway that protects mammals from viral oncogenesis

NIH-funded investigators develop therapeutic compound effective against malaria

PKM2 enzyme plays major role in early steps of wound healing

Southampton researchers explore ADAM33 gene's association with asthma, airway 'twitchiness'

Scientists sort out mechanism of Alzheimer's disease development

Researchers develop molecule that can inhibit enzyme associated with onset of stroke

CYP3A7 gene may over-activate metabolism, reduce effectiveness of cancer treatments

Specific gene mutation may significantly reduce risk of heart attack

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Tailored new compound can dramatically reduce brain damage resulting from stroke

TSRI researchers uncover new molecular mechanism underlying neurodegenerative diseases

Study reveals direct regulatory role of serotonin in rheumatoid arthritis

Discovery may provide potential target for new therapies to treat bipolar disorder

Consuming green tea with dietary iron may lessen health benefits of green tea

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Study on DNA scrunching may aid in developing new antimicrobial medicines

Study provides critical insight into Warburg effect

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

Newly developed process improves efficiency of CRISPR gene editing technology

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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