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New therapeutic targets for infantile myofibromatosis

Two mutations central to the development of infantile myofibromatosis -a disorder characterized by multiple tumors involving the skin, bone, and soft tissue-may provide new therapeutic targets, according to researchers from the Icahn School of Medicine at Mount Sinai.

26 May 2013

OPKO reports more than 50% enrollment in phase 3 trial of Rayaldy for treatment of secondary hyperparathyroidism

OPKO Health, Inc., has surpassed 50% enrollment in the first phase 3 trial of RayaldyTM to treat patients with secondary hyperparathyroidism (SHPT), stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency.

24 May 2013

TSRI scientists devise new technique to find therapeutic antibodies

Scientists at The Scripps Research Institute have devised a powerful new technique for finding antibodies that have a desired biological effect. Antibodies, which can bind to billions of distinct targets, are already used in many of the world's best-selling medicines, diagnostics and laboratory reagents.

24 May 2013

Liposomal anthracycline-based chemotherapy effective for children with leukemia: Study

Treating pediatric leukemia patients with a liposomal formulation of anthracycline-based chemotherapy at a more intense-than-standard dose during initial treatment may result in high survival rates without causing any added heart toxicity, according to the results of a study published online today in Blood, the Journal of the American Society of Hematology.

24 May 2013

Findings highlight importance of IL-21 in the development of antiviral vaccines

Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.

24 May 2013

Economic rewards have a positive effect on blood donations, say researchers

A team of researchers including Johns Hopkins Carey Business School Assistant Professor Mario Macis says the answer is an emphatic yes. Pointing to a large body of recent research that supports their argument, the three economists write in the May 24, 2013, issue of Science that the World Health Organization and national blood collection agencies should reconsider their opposition to economic incentives for much-needed blood donations.

24 May 2013

Discarded neutrophils release stem cells from bone marrow into bloodstream

CNIC researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today in the journal Cell.

24 May 2013

Algea Therapies introduces SHIELD Vertebral Compression Fracture System

Algea Therapies, a division of Globus Medical Inc. (NYSE: GMED), committed to finding innovative, minimally invasive solutions that treat pain and restore quality of life, today announced the launch of the SHIELD™ Vertebral Compression Fracture (VCF) System, a next generation fracture management and vertebral augmentation platform for patients with vertebral compression fractures.

24 May 2013

New data highlights urgent crisis posed on US healthcare system by DFUs and VLUs

Organogenesis Inc., a commercial leader in the field of regenerative medicine, presented new data generated in collaboration with a team of expert economists from Analysis Group (a leading health economics consultancy) demonstrating the significant healthcare resource and economic burden that diabetic foot ulcers and venous leg ulcers place upon the US healthcare system.

23 May 2013

FDA gives Priority Review to Celgene's ABRAXANE sNDA for advanced pancreatic cancer

Celgene International Sàrl, a subsidiary of Celgene Corporation today announced that the U.S. Food and Drug Administration has assigned a Priority Review designation to the supplemental New Drug Application for the use of ABRAXANE (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) in combination with gemcitabine for the first-line treatment of patients with advanced pancreatic cancer.

23 May 2013

Study: Calcium supplements can help women live longer

Taking a calcium supplement of up to 1,000 mg per day can help women live longer, according to a study whose lead author was Lisa Langsetmo, a Ph.D. Research Associate at McGill University, and whose senior author was Prof. David Goltzman, Division of Endocrinology and Metabolism in the Department of Medicine of the Faculty of Medicine and researcher in the Musculoskeletal Disorders axis at the Research Institute of the McGill University Health Centre (RI-MUHC).

23 May 2013

Research finds number of links between dental health and overall health

If the eyes are the windows to your soul, then your mouth is the gateway to your overall health. Research has found a surprising number of links between the state of your dental health and your overall health.

23 May 2013

Arthritis Research UK awards Cardiff researchers a grant to develop new drugs to treat osteoarthritis

Medical research charity Arthritis Research UK has awarded a team of researchers at Cardiff University a grant of £200,000 to investigate new drugs to treat early onset osteoarthritis. The team will investigate a new therapy to reduce the risk of developing osteoarthritis.

23 May 2013

Physicians face medical challenges in treating spine trauma in morbidly obese patients

Physicians at Monash University and The Alfred Hospital in Melbourne, Australia describe the logistic, medical, and societal challenges faced in treating spine trauma in morbidly obese patients.

22 May 2013

Caltech biologists show that microRNA-146a protects stem cells during inflammation

When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections and inflammation can deplete these cell populations, potentially leading to the development of serious blood conditions such as cancer.

22 May 2013

JPIDS releases consensus statement of Sentinel Project on Pediatric Drug-Resistant Tuberculosis

The Journal of the Pediatric Infectious Diseases Society today released its June issue, which includes a consensus statement of the global Sentinel Project on Pediatric Drug-Resistant Tuberculosis.

22 May 2013

Findings suggest that a prosaposin-based drug could block metastasis spread

By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces metastatic spread in mouse models of prostate, breast and lung cancer.

22 May 2013

Researchers say that receiving cancer radiation therapy late in the day may minimize hair loss

Discovering that mouse hair has a circadian clock - a 24-hour cycle of growth followed by restorative repair - researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.

21 May 2013

Joint replacement surgery might be avoidable in the future, suggest scientists

Scientists at Johns Hopkins have turned their view of osteoarthritis inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage.

20 May 2013

New computational method may help track tumor progression, risk of relapse

In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual cells. These technologies have led to new challenges, however, as scientists now struggle with how to make sense of the resulting trove of data. Now a solution may be at hand.

20 May 2013

Bone News and Research

New therapeutic targets for infantile myofibromatosis

OPKO reports more than 50% enrollment in phase 3 trial of Rayaldy for treatment of secondary hyperparathyroidism

TSRI scientists devise new technique to find therapeutic antibodies

Liposomal anthracycline-based chemotherapy effective for children with leukemia: Study

Findings highlight importance of IL-21 in the development of antiviral vaccines

Economic rewards have a positive effect on blood donations, say researchers

Discarded neutrophils release stem cells from bone marrow into bloodstream

Algea Therapies introduces SHIELD Vertebral Compression Fracture System

New data highlights urgent crisis posed on US healthcare system by DFUs and VLUs

FDA gives Priority Review to Celgene's ABRAXANE sNDA for advanced pancreatic cancer

Study: Calcium supplements can help women live longer

Research finds number of links between dental health and overall health

Arthritis Research UK awards Cardiff researchers a grant to develop new drugs to treat osteoarthritis

Physicians face medical challenges in treating spine trauma in morbidly obese patients

Caltech biologists show that microRNA-146a protects stem cells during inflammation

JPIDS releases consensus statement of Sentinel Project on Pediatric Drug-Resistant Tuberculosis

Findings suggest that a prosaposin-based drug could block metastasis spread

Researchers say that receiving cancer radiation therapy late in the day may minimize hair loss

Joint replacement surgery might be avoidable in the future, suggest scientists

New computational method may help track tumor progression, risk of relapse

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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