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Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

New study documents prevalence of food allergies

Anecdotal evidence of food allergies abounds, but just how common are these allergies and intolerances? In a new study, investigators from Brigham and Women's Hospital combed through medical records from more than 2.7 million patients, identifying more than 97,000 with one or more documented food allergy or intolerance.

31 May 2017

Handshake-free zone: keep those hands — and germs — to yourself in the hospital

Dr. Mark Sklansky, a self-described germaphobe, can't stop thinking about how quickly those little microbes can spread.

31 May 2017

Phthalate exposure linked to depressed thyroid function in young girls

Early childhood exposures to specific phthalates were associated with depressed thyroid function in girls at age 3, according to scientists at Columbia University's Mailman School of Public Health. Phthalates, a class of chemicals thought to disrupt the endocrine system, are widely used in consumer products from plastic toys to household building materials to shampoos.

30 May 2017

GW researcher receives NIH funding to explore ways for standardization of cancer genomics data

One of the biggest challenges facing cancer genomics researchers is the lack normalized data on cancer genes. Multitudes of genomics projects have been funded over the years that have resulted in data being placed on several different databases, making a wide array of data and annotations difficult to integrate and compare.

30 May 2017

Quitting methamphetamine use can prevent drug-related heart damage

Quitting methamphetamine use can reverse the damage the drug causes to the heart and improve heart function in abusers when combined with appropriate medical treatment, potentially preventing future drug-related cases of heart failure or other worse outcomes, according to a study published today in JACC: Heart Failure.

30 May 2017

Summer perils and ways to avoid, treat them

Summer can bite. It can burn or itch. It can make you extremely sick…or worse.

27 May 2017

Gray matter density increases during transition from childhood to young adulthood, study reveals

For years, the common narrative in human developmental neuroimaging has been that gray matter in the brain - the tissue found in regions of the brain responsible for muscle control, sensory perception such as seeing and hearing, memory, emotions, speech, decision making, and self-control -- declines in adolescence, a finding derived mainly from studies of gray matter volume and cortical thickness (the thickness of the outer layers of brain that contain gray matter).

26 May 2017

Diabetic donor kidneys could save lives of patients on transplant waitlist

There are more than 98,000 people currently awaiting a kidney transplant in the United States. But the organs are in short supply: only about 17,000 patients will receive transplants each year.

25 May 2017

Preliminary study: Co-occurrence of COMT and BRCA 1/2 variants may reduce breast cancer incidence

Research looking at genomic data from women with a genetic risk for breast cancer, who may never develop cancer, found their cancer-free state may be related to a second genetic variation.

25 May 2017

Scientists report brain network organization changes that underlie improvements in executive function

As children age into adolescence and on into young adulthood, they show dramatic improvements in their ability to control impulses, stay organized, and make decisions.

25 May 2017

Endoplasmic reticulum stress in the brain may cause non-alcoholic fatty liver disease

Disruptions in a protein folding process occurring in the brain, known as endoplasmic reticulum (ER) stress, may cause non-alcoholic fatty liver disease, independent of other factors. A research team at the George Washington University published their results in the Journal of Clinical Investigation Insight.

25 May 2017

Researchers discover size-sensing protein that controls glucose uptake and storage in fat cells

Researchers at the University of Iowa have discovered that a molecule which can sense the swelling of fat cells also controls a signaling pathway that allows fat cells to take up and store excess glucose.

25 May 2017

Study finds two genetic variants linked to bicuspid aortic valve development

Researchers are working to determine why the aortic valve doesn't form correctly in patients with the most common congenital heart defect: bicuspid aortic valve.

25 May 2017

Triple combination of ineffective antibiotics provides new weapon to fight against super bacteria

In the fight against super bacteria, University at Buffalo scientists are relying on strength in numbers to win the battle against drug resistance.

25 May 2017

Researchers capture first cryo-EM snapshots of key cellular receptor in action

Researchers at the University of Michigan, Stanford University and biotech company ConfometRx have captured the first cryo-electron microscopy snapshots of a key cellular receptor in action.

25 May 2017

SUNY Downstate researchers find three stressful work characteristics increasing in the U.S.

Researchers at SUNY Downstate Medical Center's School of Public Health have determined that two stressful work characteristics, low job control and "job strain" -- that is, high-demand, low-control work -- have been increasing in the U.S. since 2002.

24 May 2017

U-M research reveals important clues about invasion of polyomaviruses

Every cell in our body runs like a tiny factory that makes specialized products, using the carefully guarded instructions kept in the CEO's office.

24 May 2017

New study identifies 16 additional genetic markers linked to psoriasis

It's one of the most common immune-mediated diseases in the U.S., causing red, patchy and scaly marks on the skin. Yet the 1 to 2 percent of the population who have psoriasis are still left to wonder why.

24 May 2017

Moderate chocolate intake linked to lower risk of atrial fibrillation

A new study led by researchers at Beth Israel Deaconess Medical Center, in collaboration with researchers at the Harvard T.H. Chan School of Public Health and the Aalborg University and Institute of Cancer Epidemiology in Denmark, found that consuming moderate amounts of chocolate was associated with significantly lower risk of being diagnosed with atrial fibrillation, a common and potentially life threatening type of irregular heartbeat.

24 May 2017

Medical School News and Research

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

New study documents prevalence of food allergies

Handshake-free zone: keep those hands — and germs — to yourself in the hospital

Phthalate exposure linked to depressed thyroid function in young girls

GW researcher receives NIH funding to explore ways for standardization of cancer genomics data

Quitting methamphetamine use can prevent drug-related heart damage

Summer perils and ways to avoid, treat them

Gray matter density increases during transition from childhood to young adulthood, study reveals

Diabetic donor kidneys could save lives of patients on transplant waitlist

Preliminary study: Co-occurrence of COMT and BRCA 1/2 variants may reduce breast cancer incidence

Scientists report brain network organization changes that underlie improvements in executive function

Endoplasmic reticulum stress in the brain may cause non-alcoholic fatty liver disease

Researchers discover size-sensing protein that controls glucose uptake and storage in fat cells

Study finds two genetic variants linked to bicuspid aortic valve development

Triple combination of ineffective antibiotics provides new weapon to fight against super bacteria

Researchers capture first cryo-EM snapshots of key cellular receptor in action

SUNY Downstate researchers find three stressful work characteristics increasing in the U.S.

U-M research reveals important clues about invasion of polyomaviruses

New study identifies 16 additional genetic markers linked to psoriasis

Moderate chocolate intake linked to lower risk of atrial fibrillation

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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