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Research provides drug developers with much needed insight into serotonin receptor

Serotonin, known as the "happiness" neurotransmitter, is a chemical found in the body responsible for feelings of well-being. But serotonin isn't the only chemical that binds to the 13 serotonin receptors found on the surface of cells. Far from it. Many approved drugs also bind to serotonin receptors.

21 Aug 2018

New modeling studies highlight urgent need for effective drug policy reforms to prevent HIV

While global incidence rates of HIV have declined notably in recent years, the virus that causes AIDS remains a major and, in some ways largely unmitigated, public health threat in some countries and regions.

17 Aug 2018

Insulin resistance largely undetected in non-diabetic patients with Parkinson's disease

Almost two-thirds of non-diabetic patients with Parkinson's disease may be insulin resistant, despite having normal blood sugar, report scientists in the Journal of Parkinson's Disease.

3 Aug 2018

New nuclear medicine test could improve care of patients with type 1 diabetes

Researchers have discovered a new nuclear medicine test that could improve care of patients with type 1 diabetes. The new positron emission tomography imaging method could measure beta-cell mass, which would greatly enhance the ability to monitor and guide diabetes therapies.

3 Aug 2018

Protein known to drive nerve cell survival may protect children from Duchenne cardiomyopathy

A protein known to drive nerve cell survival in the brain and spinal cord might also protect failing hearts in children and young adults with Duchenne muscular dystrophy, according to preliminary research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions, a premier global exchange of the latest advances in basic cardiovascular science.

2 Aug 2018

Exenatide treatment improves depression symptoms in PD patients

Non-motor symptoms of Parkinson's disease, such as depression, apathy, cognitive impairment, sleep disorders, and sensory symptoms, can have a greater impact on health-related quality of life than motor deficits.

1 Aug 2018

Cannabis appears to have no effect on breathlessness during exercise in advanced COPD patients

Inhaled vaporized cannabis does not appear to improve or worsen exercise performance and activity-related breathlessness in patients with advanced chronic obstructive pulmonary disease, according to a randomized controlled trial published online in the Annals of the American Thoracic Society.

27 Jul 2018

Aggressive lowering of blood pressure reduces MCI risk, study shows

Significant reductions in the risk of mild cognitive impairment (MCI), and the combination of MCI and dementia, have been shown for the first time through aggressive lowering of systolic blood pressure in new research results from the federally-funded SPRINT MIND Study reported at the Alzheimer's Association International Conference 2018 in Chicago.

25 Jul 2018

Opioid patients face several barriers to treatment, study finds

In areas of the country disproportionately affected by the opioid crisis, treatment programs are less likely to accept patients paying through insurance of any type or accept pregnant women, a new Vanderbilt study found.

12 Jul 2018

Atlantic Health System starts enrolling patients in four pancreatic cancer clinical trials

Atlantic Health System is now enrolling patients in four pancreatic cancer clinical trials. Angela Alistar, MD, a nationally known expert on pancreatic cancer, is serving as national Principal Investigator on the first trial and as local PI on three other trials.

30 Jun 2018

Penn cancer researchers reveal secrets of 'hot' and 'cold' pancreatic tumors

So-called "hot" tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to "cold" tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists--until now.

29 Jun 2018

UC Riverside researcher receives grants to advance cancer, ALS research

Maurizio Pellecchia, who holds the Daniel Hays Chair in Cancer Research at the University of California, Riverside, has received two grants to continue his research aimed at finding therapeutics for cancer, amyotrophic lateral sclerosis, and other neurodegenerative diseases.

21 Jun 2018

Impulse control disorders found to be more common in people taking Parkinson's drugs

Over time, half of the people taking certain drugs for Parkinson's disease may develop impulse control disorders such as compulsive gambling, shopping or eating, according to a study published in the June 20, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.

20 Jun 2018

Study: Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis

The results of an open label extension of a phase II study presented today at the Annual European Congress of Rheumatology, 2018, demonstrate that lenabasum continues to have acceptable safety and tolerability in diffuse cutaneous systemic sclerosis with no severe or serious adverse events.

18 Jun 2018

New nuclear medicine method appears to effectively detect neuroendocrine tumors

Researchers have shown that a new nuclear medicine procedure could safely and more effectively detect cancerous gastrointestinal and pancreatic neuroendocrine tumors than current methods.

7 Jun 2018

Novel surgical approach to limb amputation improves sensation, control of prosthesis

Humans can accurately sense the position, speed and torque of their limbs, even with their eyes shut. This sense, known as proprioception, allows humans to precisely control their body movements.

30 May 2018

Researchers seek new approaches to better protect the eye from glaucoma

Under the increased pressure of glaucoma, scientists want to help the neurons in our eyes better protect themselves and get better help from their friends.

29 May 2018

FDA OKs first non-opioid drug for adults with opioid withdrawal symptoms

The United States Food and Drugs Administration (FDA), in a statement this week, approved a new drug Lucemyra (lofexidine hydrochloride) for the treatment and alleviation of opioid symptom withdrawal symptoms in adults in whom the drugs have been withdrawn abruptly.

17 May 2018

International study finds viable treatment option for people with mild asthma

A large international study led by a Hamilton researcher has found a patient-centric treatment that works for people with mild asthma.

17 May 2018

FDA approves new treatment to mitigate opioid withdrawal symptoms in adults

The U.S. Food and Drug Administration today approved Lucemyra (lofexidine hydrochloride) for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults.

17 May 2018

Agonist News and Research

Research provides drug developers with much needed insight into serotonin receptor

New modeling studies highlight urgent need for effective drug policy reforms to prevent HIV

Insulin resistance largely undetected in non-diabetic patients with Parkinson's disease

New nuclear medicine test could improve care of patients with type 1 diabetes

Protein known to drive nerve cell survival may protect children from Duchenne cardiomyopathy

Exenatide treatment improves depression symptoms in PD patients

Cannabis appears to have no effect on breathlessness during exercise in advanced COPD patients

Aggressive lowering of blood pressure reduces MCI risk, study shows

Opioid patients face several barriers to treatment, study finds

Atlantic Health System starts enrolling patients in four pancreatic cancer clinical trials

Penn cancer researchers reveal secrets of 'hot' and 'cold' pancreatic tumors

UC Riverside researcher receives grants to advance cancer, ALS research

Impulse control disorders found to be more common in people taking Parkinson's drugs

Study: Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis

New nuclear medicine method appears to effectively detect neuroendocrine tumors

Novel surgical approach to limb amputation improves sensation, control of prosthesis

Researchers seek new approaches to better protect the eye from glaucoma

FDA OKs first non-opioid drug for adults with opioid withdrawal symptoms

International study finds viable treatment option for people with mild asthma

FDA approves new treatment to mitigate opioid withdrawal symptoms in adults

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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