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New breakthrough offers hope for allergy sufferers

Scientists from The University of Queensland believe they have discovered a single treatment that could be a life-long cure for potentially fatal allergies such as asthma.

5 Jun 2017

New targeted oral therapy results in durable responses across many kinds of cancer

Scientists may have developed the first targeted, oral, tumor-type agnostic therapy - a cancer medicine that works comparably well across many kinds of cancer, regardless of patient age. In clinical trials of adults and children with 17 different types of advanced cancer, larotrectinib treatment resulted in responses in 76% of patients.

5 Jun 2017

OIST researchers identify new toxic mechanism behind Parkinson’s disease

OIST researchers have identified the precise toxic mechanism at work during an overabundance of the protein alpha-synuclein in neurons—the protein is a key causative agent in the development of Parkinson's disease.

5 Jun 2017

Combination therapy shows potential for effective treatment of RAS-mutant cancers

A study at The University of Texas MD Anderson Cancer Center has shown promise for effective treatment of therapy-resistant cancers caused by a mutation of the RAS gene found in many cancers.

2 Jun 2017

Follistatin plays key role in embryo implantation

Looking to improve the success rate of assisted reproductive technologies, researchers at Baylor College of Medicine investigated in more detail the mechanism involved in successful embryo implantation, an essential component of female fertility.

2 Jun 2017

Olive oil component may help prevent cancer developing in the brain

A compound found in olive oil may help to prevent cancer developing in the brain, a study shows. Research into oleic acid -- the primary ingredient in olive oil -- has shown how it can help prevent cancer-causing genes from functioning in cells.

2 Jun 2017

Gene therapy could give protection from severe allergies

A single treatment giving life-long protection from severe allergies such as asthma could be made possible by immunology research at The University of Queensland.

2 Jun 2017

Scientists create new method to make peptide stapling widely available

UK scientists have created a new method to structure peptides, which they say will be cheaper and make the process of using stapled peptides in drug discovery much more widely available.

2 Jun 2017

Study underlines significance of microglia for homeostasis in the brain

The role of microglial cells in neurodegenerative disease is not fully understood. But new results from researchers in Munich and Basel suggest that stimulation of this arm of the immune system might well delay the onset of such disorders.

2 Jun 2017

Early study of experimental vaccine shows escalating immune response in patients with sarcoma

The critical component of an experimental vaccine led to an escalating immune response in patients with sarcoma, an indicator of its potential anti-cancer effects.

2 Jun 2017

New study suggests potential new therapeutic approach to septic shock recovery

A new study published online in the Journal of Leukocyte Biology suggests a new approach to treating patients with sepsis, one of the most frequent causes of morbidity and mortality in intensive care units.

1 Jun 2017

TSRI study reveals first-ever structure of Lassa virus protein

Before Ebola virus ever struck West Africa, locals were already on the lookout for a deadly pathogen: Lassa virus. With thousands dying from Lassa every year - and the potential for the virus to cause even larger outbreaks- researchers are committed to designing a vaccine to stop it.

1 Jun 2017

LMU researchers show how genetic variant in people of African ancestry modulates immune cells

A genetic variant that is particularly prevalent in people of African ancestry confers protection against malaria. LMU researchers have now shown how it modulates the properties of white blood cells that play a major role in immune defenses and inflammation.

1 Jun 2017

Scientists identify new gene that prompts muscle stem cells to fuse together

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.

1 Jun 2017

Chronic pain may occur when receptors migrate from nerve cell's surface to inner chambers

A study led by Columbia University Medical Center has shown that chronic pain may occur when pain receptors migrate from the nerve cell's surface to the cell's inner chambers, out of the reach of current pain medications.

1 Jun 2017

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Subgroups of tuberculosis (TB)-causing bacteria can persist even when antibiotics wipe out most of the overall population. The need to eliminate these persistent subpopulations is one reason why TB treatment regimens are so lengthy.

1 Jun 2017

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

A phase 2 clinical trial in young adults with Down syndrome of a drug being investigated for the treatment of Alzheimer's disease supports further investigation of its potential.

1 Jun 2017

Researchers discover molecular signaling circuit that regulates autophagy

Autophagy is the recycling process by which our cells keep themselves young. They continually break down and renew small parts of themselves in a kind of self-digestion; this helps to counteract harmful deposits which may form.

1 Jun 2017

TSRI professor receives $2 million grant to study neurofibromatosis type I

Assistant Professor Seth Tomchik of the Florida campus of The Scripps Research Institute (TSRI) has received $2 million in funding from the National Institutes of Health's National Institute of Neurological Disorders and Stroke.

31 May 2017

Collaborative effort to develop rare disease patient registries

The Orphan Disease Center in the Perelman School of Medicine at the University of Pennsylvania will collaborate with Pulse Infoframe Inc., a medical informatics company, to develop rare disease patient registries aimed at enabling international collaboration to better understand these diseases, as well as accelerate and improve clinical studies to develop new therapies.

31 May 2017

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G Protein News and Research

New breakthrough offers hope for allergy sufferers

New targeted oral therapy results in durable responses across many kinds of cancer

OIST researchers identify new toxic mechanism behind Parkinson’s disease

Combination therapy shows potential for effective treatment of RAS-mutant cancers

Follistatin plays key role in embryo implantation

Olive oil component may help prevent cancer developing in the brain

Gene therapy could give protection from severe allergies

Scientists create new method to make peptide stapling widely available

Study underlines significance of microglia for homeostasis in the brain

Early study of experimental vaccine shows escalating immune response in patients with sarcoma

New study suggests potential new therapeutic approach to septic shock recovery

TSRI study reveals first-ever structure of Lassa virus protein

LMU researchers show how genetic variant in people of African ancestry modulates immune cells

Scientists identify new gene that prompts muscle stem cells to fuse together

Chronic pain may occur when receptors migrate from nerve cell's surface to inner chambers

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

Researchers discover molecular signaling circuit that regulates autophagy

TSRI professor receives $2 million grant to study neurofibromatosis type I

Collaborative effort to develop rare disease patient registries

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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