Induced Pluripotent Stem Cells News and Research

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Reprogrammed human skin cells highly effective in treating myelin disorders

A study out today in the journal Cell Stem Cell shows that human brain cells created by reprogramming skin cells are highly effective in treating myelin disorders, a family of diseases that includes multiple sclerosis and rare childhood disorders called pediatric leukodystrophies.

10 Feb 2013

Scientists report first generation of hiPSCs from patients with maturity onset diabetes of the young

Joslin scientists report the first generation of human induced pluripotent stem cells from patients with an uncommon form of diabetes, maturity onset diabetes of the young (MODY). These cells offer a powerful resource for studying the role of genetic factors in the development of MODY and testing potential treatments.

2 Feb 2013

Researchers unveil first maturation-based ‘disease in a dish’ model for ARVD/C

Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem.

29 Jan 2013

Skin cells transformed into heart cells for research into cardiomyopathy

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28 Jan 2013

Researchers discover safe and efficient way to get large molecules through the cell membrane

Living cells are surrounded by a membrane that tightly regulates what gets in and out of the cell. This barrier is necessary for cells to control their internal environment, but it makes it more difficult for scientists to deliver large molecules such as nanoparticles for imaging, or proteins that can reprogram them into pluripotent stem cells.

24 Jan 2013

Salk Institute to establish Helmsley Center for Genomic Medicine

The Salk Institute for Biological Studies has received a $42 million gift-the largest in the Institute's history-to establish the Helmsley Center for Genomic Medicine (HCGM), a research center dedicated to decoding the common genetic factors underlying many complex chronic human diseases.

23 Jan 2013

Apparent stem cell transplant success in mice may hold promise for people with ALS

Apparent stem cell transplant success in mice may hold promise for people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

11 Jan 2013

Manipulating T cells with iPSC techniques could help develop effective immune therapies

The human body contains immune cells programmed to fight cancer and viral infections, but they often have short lifespans and are not numerous enough to overcome attacks by particularly aggressive malignancies or invasions.

4 Jan 2013

Researchers create killer T lymphocytes from iPS cells

Researchers from the RIKEN Research Centre for Allergy and Immunology in Japan report today that they have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS cells).

4 Jan 2013

Stanford scientists identify molecular basis for hypertrophic cardiomyopathy

When a young athlete dies unexpectedly on the basketball court or the football field, it's both shocking and tragic. Now Stanford University School of Medicine researchers have, for the first time, identified the molecular basis for a condition called hypertrophic cardiomyopathy that is the most common cause for this type of sudden cardiac death.

4 Jan 2013

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.

21 Dec 2012

New work on Akt's role in cancer stem cell biology

The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Honglin Zhou, MD, PhD and Weihua Li, co-first author, both from the Center for Resuscitation Sciences, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, and Xiaowei Xu, Department of Pathology and Laboratory Medicine, appears in Molecular Cell.

21 Dec 2012

Cedars-Sinai physician-scientist receives grant to study Charcot-Marie-Tooth disease

A Cedars-Sinai physician-scientist has been awarded a $3 million grant from the California Institute for Regenerative Medicine to study with new stem cell technology Charcot-Marie-Tooth disease, the most common inherited neurological disorder and which damages nerves that control muscles.

14 Dec 2012

Cedars-Sinai scientist to study Charcot-Marie-Tooth disease

14 Dec 2012

New method promises to boost stem cell production in laboratory

A new method for generating stem cells from mature cells promises to boost stem cell production in the laboratory, helping to remove a barrier to regenerative medicine therapies that would replace damaged or unhealthy body tissues.

5 Dec 2012

USPTO approves patent for Axiogenesis’ in vitro drug discovery assay to treat HCM

The USPTO approved a patent for Axiogenesis AG for the invention of its in vitro assay to screen pharmaceutical drug candidates for effectiveness and safety in treating Hypertrophic Cardiomyopathy (HCM).

5 Dec 2012

Engineers develop simple and inexpensive way to create 3-D brain tissues in lab dishes

Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish.

30 Nov 2012

Answers to the questions of stem cells

Next week, more than 1,200 people from 25 countries are expected to attend the 8th Annual World Stem Cell Summit in West Palm Beach, Fla., a gathering co-sponsored by Mayo Clinic. As those close to the science explore potential stem cell applications, many patients have questions about what stem cells are and how they are being used. Timothy Nelson, M.D., Ph.D., director of Mayo Clinic's Regenerative Medicine Consult Service, answers some of the most commonly asked questions about stem cells.

29 Nov 2012

Breakthrough in heart research

Breakthrough in heart research: The research team from Professor Katja Schenke-Layland of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart has discovered cell surface markers that enable the identification and isolation of living functional cardiovascular progenitor cells (CPCs).

22 Nov 2012

Induced-pluripotent stem cells not as genetically unstable as previously thought

Stanford University School of Medicine scientists have demonstrated, in a study conducted jointly with researchers at Yale University, that induced-pluripotent stem cells - the embryonic-stem-cell lookalikes whose discovery a few years ago won this year's Nobel Prize in medicine - are not as genetically unstable as was thought.

19 Nov 2012

Induced Pluripotent Stem Cells News and Research

Reprogrammed human skin cells highly effective in treating myelin disorders

Scientists report first generation of hiPSCs from patients with maturity onset diabetes of the young

Researchers unveil first maturation-based ‘disease in a dish’ model for ARVD/C

Skin cells transformed into heart cells for research into cardiomyopathy

Researchers discover safe and efficient way to get large molecules through the cell membrane

Salk Institute to establish Helmsley Center for Genomic Medicine

Apparent stem cell transplant success in mice may hold promise for people with ALS

Manipulating T cells with iPSC techniques could help develop effective immune therapies

Researchers create killer T lymphocytes from iPS cells

Stanford scientists identify molecular basis for hypertrophic cardiomyopathy

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

New work on Akt's role in cancer stem cell biology

Cedars-Sinai physician-scientist receives grant to study Charcot-Marie-Tooth disease

Cedars-Sinai scientist to study Charcot-Marie-Tooth disease

New method promises to boost stem cell production in laboratory

USPTO approves patent for Axiogenesis’ in vitro drug discovery assay to treat HCM

Engineers develop simple and inexpensive way to create 3-D brain tissues in lab dishes

Answers to the questions of stem cells

Breakthrough in heart research

Induced-pluripotent stem cells not as genetically unstable as previously thought

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