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Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Scientists from the Florida campus of The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects—and reverse the disease.

6 Jan 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery

The results of the largest international study to date into the genetic basis of rheumatoid arthritis shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis.

26 Dec 2013

Schizophrenia brain marker matches genetic risk

Polygenic risk for schizophrenia correlates with neural inefficiency in the left dorsolateral prefrontal cortex, say researchers.

24 Dec 2013

Finding suggests new route for packaging RNA molecules of interest into nanovesicles

The role of microRNAs is fundamental for the correct moment-to-moment adjustment in the expression of target genes. "Before this study, we already knew that these small molecules could be packaged into small vesicles and exported to the extracellular space, to be later captured by other cells and in this way play an important role in intercellular communication," explains CNIC researcher Carolina Villarroya, the first author on the study.

23 Dec 2013

Researchers map cell's complex genetic interactions to fix UV damaged DNA

Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet (UV) radiation.

19 Dec 2013

Shared genetic risk for bipolar disorder and BMI

Researchers have found a positive association in the heritability of bipolar disorder and body mass index, supporting the theory that there is some interaction in the genetic mechanisms underlying these two traits.

19 Dec 2013

Study reveals why people are predisposed to cardiovascular disease and death

A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists at Duke Medicine report.

19 Dec 2013

UCD Conway Institute researchers identify potential biomarker of idiopathic pulmonary ﬁbrosis

Researchers in UCD Conway Institute have identified a potential biomarker of rapidly progressive pulmonary fibrosis and pinpointed a defective molecular function as a potential therapeutic target.

18 Dec 2013

New research project to genetically discriminate "identical" monozygotic twins

Eurofins Scientific, a European leader in Genomics Services, Forensics and Paternity Testing, announces a milestone in genetic and forensic research.

10 Dec 2013

Eurofins successfully completes genetic and forensic research project on twins

Eurofins Scientific, one of the global leaders in Genomics Services, announces a research breakthrough in genetic discrimination between identical monozygotic twins.

10 Dec 2013

Archimedes Model simulation suggests genetic screening for breast cancer risk can reduce deaths

Archimedes Inc., a healthcare modeling and analytics company, today announced results of a simulated clinical trial which found that the seven single-nucleotide polymorphisms (7SNP) genetic test for breast cancer was most cost effective when used to guide MRI screenings for patients found to have an intermediate lifetime risk of developing the disease.

5 Dec 2013

Women who test negative for family-specific BRCA2 mutations may have four times risk for breast cancer

Women who are members of families with BRCA2 mutations but who test negative for the family-specific BRCA2 mutations are still at greater risk for developing breast cancer compared with women in the general population, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

27 Nov 2013

Researchers repurpose genetic data, electronic medical records to perform large-scale PheWAS study

Vanderbilt University Medical Center researchers and co-authors from four other U.S. institutions from the Electronic Medical Records and Genomics (eMERGE) Network are repurposing genetic data and electronic medical records to perform the first large-scale phenome-wide association study (PheWAS), released today in Nature Biotechnology.

26 Nov 2013

Seed grants support cancer diagnosis and treatment, vascular health research

Five teams of scientists earned research seed grants awarded this year by the John S. Dunn Foundation. The awards support new collaborations by researchers at Rice University's BioScience Research Collaborative (BRC) and their partners at other institutional members of the Gulf Coast Consortia (GCC).

26 Nov 2013

Researchers discover how type 2 diabetes drug metformin actually works

Researchers from St. Vincent's Institute of Medical Research in Melbourne, Australia, in collaboration with researchers at McMaster University in Canada, are reportedly the first to discover how the type 2 diabetes drug metformin actually works, providing a molecular understanding that could lead to the development of more effective therapies. Mass spectrometry technologies from AB SCIEX, a global leader in analytical technologies, played a critical role in the analysis that led to this breakthrough finding.

25 Nov 2013

Parkinson's Institute, Population Diagnostics discover new genes relevant to Parkinson's disease

The Parkinson's Institute and Clinical Center announced today that they, in partnership with Population Diagnostics, Inc., have discovered a number of new genes relevant to the cause of Parkinson's disease.

20 Nov 2013

Curie-Cancer inks partnership agreements with Meiogenix to develop SpiX technology

Curie-Cancer, the body responsible for developing Institut Curie's industry partnership activity, today announces two three-year partnership agreements with Meiogenix, a French SME. Meiogenix develops SpiX technology under license from Institut Curie and Institut National de la Recherche Agronomique.

19 Nov 2013

ESBC joins with Athena Breast Health Network to advance personalized breast cancer risk assessment

Edith Sanford Breast Cancer (ESBC), part of the Sanford Health system based in Sioux Falls, SD, today announced it is partnering with the Athena Breast Health Network, a University of California program, to advance the use of a personalized breast cancer risk assessment.

16 Nov 2013

Researchers identify novel therapeutic approach for most frequent genetic cause of ALS

A team of scientists led by researchers from the University of California, San Diego School of Medicine and Ludwig Institute for Cancer Research have identified a novel therapeutic approach for the most frequent genetic cause of ALS, a disorder of the regions of the brain and spinal cord that control voluntary muscle movement, and frontal temporal degeneration, the second most frequent dementia.

10 Nov 2013

Coding variants in immune disease-related genes play only small part in risk for psoriasis

Coding variants in immune disease-related genes play only a small part in the overall genetic risk for psoriasis, according to a new study led by Anhui Medical University and BGI.

10 Nov 2013

Nucleotides News and Research

Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Schizophrenia brain marker matches genetic risk

Finding suggests new route for packaging RNA molecules of interest into nanovesicles

Researchers map cell's complex genetic interactions to fix UV damaged DNA

Shared genetic risk for bipolar disorder and BMI

Study reveals why people are predisposed to cardiovascular disease and death

UCD Conway Institute researchers identify potential biomarker of idiopathic pulmonary ﬁbrosis

New research project to genetically discriminate "identical" monozygotic twins

Eurofins successfully completes genetic and forensic research project on twins

Archimedes Model simulation suggests genetic screening for breast cancer risk can reduce deaths

Women who test negative for family-specific BRCA2 mutations may have four times risk for breast cancer

Researchers repurpose genetic data, electronic medical records to perform large-scale PheWAS study

Seed grants support cancer diagnosis and treatment, vascular health research

Researchers discover how type 2 diabetes drug metformin actually works

Parkinson's Institute, Population Diagnostics discover new genes relevant to Parkinson's disease

Curie-Cancer inks partnership agreements with Meiogenix to develop SpiX technology

ESBC joins with Athena Breast Health Network to advance personalized breast cancer risk assessment

Researchers identify novel therapeutic approach for most frequent genetic cause of ALS

Coding variants in immune disease-related genes play only small part in risk for psoriasis

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