Omicron News and Research

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Third dose of COVID-19 mRNA vaccine offers cirrhosis patients strong protection against the virus

Cirrhosis of the liver is associated with decreased responsiveness to many vaccines, including those that protect against COVID-19.

27 Oct 2022

Study examines the severity of the SARS-CoV-2 Omicron BA.2 subvariant

In a recent study that represents the largest to date to examine the severity of the SARS-CoV-2 Omicron BA.2 subvariant (the strain making a re-emergence this fall), a team led by investigators at Massachusetts General Hospital (MGH) determined that the BA.2 subvariant is less severe than the previous Delta variant and less severe to an even greater extent than the original Omicron variant.

27 Oct 2022

Is vaccine status associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients?

Researchers assessed the impact of SARS-CoV-2 vaccination on the occurrence and severity of symptoms in SARS-CoV-2 Omicron-infected hospitalized patients.

27 Oct 2022

The effectiveness of BNT162b2 COVID-19 vaccine against infection with SARS-CoV-2 Omicron subvariants BA.4/5

Researchers evaluated the vaccine effectiveness of Pfizer-BioNTech’s BNT162b2 COVID-19 vaccines against SARS-CoV-2 Omicron BA.4/5.

27 Oct 2022

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Researchers comparatively evaluated the neutralization antibody titers for SARS-CoV-2 Omicron VOC subvariants BA.1, BA.2, BA.4/5 among individuals with ancestral B.1 strain infections, vaccinated individuals, or with hybrid immunity from breakthrough infections and vaccinations with Delta or Gamma VOCs.

27 Oct 2022

Monoclonal antibodies generated from COVID-19-recovered individuals shed light on the molecular basis of SARS-CoV-2 Omicron variant immune evasion

Researchers reported three human monoclonal antibodies generated from COVID-19-recovered individuals during the initial wave of the pandemic in India.

27 Oct 2022

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

A study tested the hypothesis that the ACE-2 receptor of SARS-CoV-2 is not only an attachment factor in viral infection but also plays a role in activating the viral spike protein to facilitate membrane fusion.

27 Oct 2022

Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine

Researchers analyzed the antibody response induced by the new bivalent mRNA SARS-CoV-2 vaccines in individuals who have been fully vaccinated with monovalent vaccines and those who have had breakthrough infection with the SARS-CoV-2 Omicron BA.4/BA.5 variants.

26 Oct 2022

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Researchers analyzed the phenotypes of the SARS-CoV-2 variants of concern (VOCs), the molecular responses to infections from these VOCs, and the evolving virus-host interactions using a comparative genomic and proteomic approach.

26 Oct 2022

SARS-CoV-2 BQ.1 variant cases may increase in Europe

A recent epidemiological update by the European Center for Disease Prevention and Control indicated that a new SARS-CoV-2 Omicron sublineage was likely to increase COVID-19 case numbers.

26 Oct 2022

Is there a difference in the risk of hospital admission between BA.1 and BA.2 cases treated with Sotrovimab?

Researchers compared the risk associated with hospitalization of sotrovimab-treated individuals infected with SARS-CoV-2 Omicron variants.

25 Oct 2022

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Researchers designed a COVID-19 vaccine construct using hybrid SARS-CoV-2 S protein (containing SARS-CoV-2 Delta and Omicron variant mutations) and N protein peptides that confer T lymphocyte-mediated immune protection.

25 Oct 2022

The impact of existing and theoretical mutations on SARS-CoV-2 CD8+ T cell targets

Researchers evaluated the effect of mutations in SARS-CoV-2 variants of concern on CD8+ T cell responses.

25 Oct 2022

Heart attack death rates took a sharp turn and increased during the pandemic, study shows

New data analysis from the Smidt Heart Institute at Cedars-Sinai found that deaths from heart attacks rose significantly during pandemic surges, including the COVID-19 Omicron surges, overall reversing a heart-healthier pre-pandemic trend.

24 Oct 2022

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

In a new study, researchers performed an in vitro analysis to isolate ultralong bovine heavy chains that showed binding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses (CoVs).

24 Oct 2022

What is the efficacy of mulberry component Kuwanon C against COVID-19?

A recent study determined the underlying antiviral mechanism of KC associated with the inhibition of SARS-CoV-2.

24 Oct 2022

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Researchers performed a longitudinal cohort study to assess the levels of immunoglobulins M (IgM), G (IgG), and A (IgA) against the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

24 Oct 2022

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

Researchers evaluated imprinted antibody responses against SARS-CoV-2 Omicron sublineages.

24 Oct 2022

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

Researchers investigated the efficacy of monovalent mRNA COVID-19 vaccines in immunocompromised adults during the Omicron dominance period starting December 2021.

24 Oct 2022

COVID-19 vaccination during pregnancy protects infants from SARS-CoV-2 infection

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers evaluated the efficacy of maternal coronavirus disease 2019 (COVID-19) vaccination against infection of infants with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

24 Oct 2022

Omicron News and Research

Third dose of COVID-19 mRNA vaccine offers cirrhosis patients strong protection against the virus

Study examines the severity of the SARS-CoV-2 Omicron BA.2 subvariant

Is vaccine status associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients?

The effectiveness of BNT162b2 COVID-19 vaccine against infection with SARS-CoV-2 Omicron subvariants BA.4/5

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Monoclonal antibodies generated from COVID-19-recovered individuals shed light on the molecular basis of SARS-CoV-2 Omicron variant immune evasion

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

SARS-CoV-2 BQ.1 variant cases may increase in Europe

Is there a difference in the risk of hospital admission between BA.1 and BA.2 cases treated with Sotrovimab?

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

The impact of existing and theoretical mutations on SARS-CoV-2 CD8+ T cell targets

Heart attack death rates took a sharp turn and increased during the pandemic, study shows

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

What is the efficacy of mulberry component Kuwanon C against COVID-19?

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

COVID-19 vaccination during pregnancy protects infants from SARS-CoV-2 infection

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