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Research: SSeCKS/AKAP12 gene key inhibitor of prostate cancer metastasis

New evidence reported by researchers at Roswell Park Cancer Institute (RPCI) lends support to the hypothesis that the SSeCKS/AKAP12 gene is a key inhibitor of prostate cancer metastasis.

4 Feb 2014

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

In a study published this week in Nature Neuroscience, Bess Frost, PhD, and co-authors, identify abnormal expression of genes, resulting from DNA relaxation, that can be detected in the brain and blood of Alzheimer's patients.

31 Jan 2014

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Patients with advanced hepatocellular (or liver) cancer have high mortality rates, with existing drugs demonstrating only a small, but significant survival advantage. By combining a zebrafish model of liver cancer with data from human tumors, researchers from the Icahn School of Medicine at Mount Sinai hope to identify potential genes of interest that can be targeted for new treatments for hepatocellular carcinoma, the most common form of liver cancer to develop from liver cells.

31 Jan 2014

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2), have been identified in approximately 20 percent of all acute myeloid leukemias (AML). As a result, mutant IDH proteins have been proposed as attractive drug targets for this common form of adult leukemia.

29 Jan 2014

Researchers detect cancer cells using olfactory senses of fruit flies

A research unit in an international cooperation project, led by the Konstanz-based neurobiologist and zoologist Professor Dr. Giovanni Galizia, has been the first to demonstrate that fruit flies are able to distinguish cancer cells from healthy cells via their olfactory sense.

25 Jan 2014

Novel HER2 mutation identified in familial lung adenocarcinomas

Researchers have identified a novel germline mutation in the transmembrane domain of the human epidermal growth factor receptor 2 gene in familial lung adenocarcinomas.

24 Jan 2014

Early onset of dietary treatment may slow down progression of Alzheimer's disease

New research findings indicate that an early onset of dietary treatment may slow down the progression of Alzheimer's disease. The study was conducted on mice, and the results will be published in the February issue of Journal of Nutritional Biochemistry. Researchers from the University of Eastern Finland played a key role in the study, which was carried out as part of the LiPiDiDiet project funded by the European Union.

24 Jan 2014

Moderate radiation doses can kill premalignant cells and prevent second breast cancers

Survivors of breast cancer have a one in six chance of developing breast cancer in the other breast. But a study conducted in mice suggests that survivors can dramatically reduce that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast.

24 Jan 2014

Early onset of dietary treatment may slow down progression of Alzheimer's, says research

24 Jan 2014

Professor wins NSF CAREER grant to develop 5-D in vivo image of atherosclerotic plaques

Currently, the medical community has limited ability in clinically assessing blockages called atherosclerotic plaques in the human body. These dangerous blockages that can lead to heart attacks and strokes are not easily diagnosed due to "the lack of noninvasive imaging techniques to accurately model atherosclerotic plaques in vivo," said Guohua Cao, assistant professor of biomedical engineering at Virginia Tech.

17 Jan 2014

AP-1 proteins modulate fat accumulation in liver, say researchers

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease.

8 Jan 2014

Study suggests that ROR1 could be an important therapeutic target for patients with CLL

Researchers at the University of California, San Diego School of Medicine report that an oncogene dubbed ROR1, found on chronic lymphocytic leukemia (CLL) B cells but not normal adult tissues, acts as an accelerant when combined with another oncogene, resulting in a faster-developing, more aggressive form of CLL in mice.

3 Jan 2014

Patients with Loeys-Dietz syndrome at increased risk for aortic aneurysm

Patients with the connective tissue disorder Loeys-Dietz syndrome are at high risk for aortic aneurysm. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF-β. LDS-associated mutations are predicted to reduce TGF-β signaling; however, aortic tissue samples from LDS patients indicate that TGF-β signaling may be enhanced.

22 Dec 2013

Research findings point to possible new strategy for treating ALS

Amyotrophic lateral sclerosis, better known as Lou Gehrig's disease, is a devastating illness that gradually robs sufferers of muscle strength and eventually causes a lethal, full-body paralysis. The only drug available to treat the disease extends life spans by a meager three months on average.

17 Dec 2013

New book provides cutting-edge methods for generating and characterizing mouse cancer models

The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics.

12 Dec 2013

NOXXON Pharma reports interim data from two phase IIa studies of anti-CXCL12/SDF-1 Spiegelmer NOX-A12

NOXXON Pharma disclosed interim data from two independent clinical phase IIa studies of the anti-CXCL12/SDF-1 Spiegelmer olaptesed pegol (NOX-A12) at the 55th annual meeting of the American Society of Hematology in New Orleans, LA, USA from 7-10 December 2013.

9 Dec 2013

ALS TDI forms research partnership with Neurimmune to advance potential treatments for ALS

The ALS Therapy Development Institute (ALS TDI), together with its wholly-owned subsidiary, Anelixis Therapeutics, announced today that it has formed a research partnership with Neurimmune to advance potential treatments for ALS, also known as Lou Gehrig's disease.

6 Dec 2013

Molecular mechanisms of NR2B regulates age-related memory storage, brain aging

The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly associated with memory impairment.

6 Dec 2013

New genetics promises to change faulty genes of future generations by using "designer sperm”

Bethesda, MD-Get ready: The "new genetics" promises to change faulty genes of future generations by introducing new, functioning genes using "designer sperm." A new research report appearing online in The FASEB Journal, shows that introducing new genetic material via a viral vector into the sperm of mice leads to the presence and activity of those genes in the resulting embryos.

3 Dec 2013

Cyclin D1 protein controls cell cycle progression, microRNA biogenesis in breast cancer

Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research publishing November 29 in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome. The non-coding genome, previously referred to as junk DNA, makes up most of the human genome, and unlike the coding genome, varies greatly between species.

29 Nov 2013

Transgenic News and Research

Research: SSeCKS/AKAP12 gene key inhibitor of prostate cancer metastasis

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

Researchers detect cancer cells using olfactory senses of fruit flies

Novel HER2 mutation identified in familial lung adenocarcinomas

Early onset of dietary treatment may slow down progression of Alzheimer's disease

Moderate radiation doses can kill premalignant cells and prevent second breast cancers

Early onset of dietary treatment may slow down progression of Alzheimer's, says research

Professor wins NSF CAREER grant to develop 5-D in vivo image of atherosclerotic plaques

AP-1 proteins modulate fat accumulation in liver, say researchers

Study suggests that ROR1 could be an important therapeutic target for patients with CLL

Patients with Loeys-Dietz syndrome at increased risk for aortic aneurysm

Research findings point to possible new strategy for treating ALS

New book provides cutting-edge methods for generating and characterizing mouse cancer models

NOXXON Pharma reports interim data from two phase IIa studies of anti-CXCL12/SDF-1 Spiegelmer NOX-A12

ALS TDI forms research partnership with Neurimmune to advance potential treatments for ALS

Molecular mechanisms of NR2B regulates age-related memory storage, brain aging

New genetics promises to change faulty genes of future generations by using "designer sperm”

Cyclin D1 protein controls cell cycle progression, microRNA biogenesis in breast cancer

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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