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Researchers analyze how Topo II enzyme may affect stability of genomes

While researchers are now familiar with how cancer begins—cells mutate and then multiply wildly out of control—it is still uncertain exactly how that mutation starts in the molecules of the cells.

22 Feb 2016

Researchers identify common molecular alteration in glioblastoma

Glioblastoma is the most aggressive manifestation of brain tumours. Due to its high invasive capacity and uncontrolled, infiltrating growth, it is particularly difficult to manage. Currently, the treatment for this disease consists of a combination of surgery (when possible), radiation and chemotherapy.

22 Feb 2016

Kellogg investigators develop new nanotechnology that has potential to kill tumor cells in the eye

Researchers at the University of Michigan Kellogg Eye Center have developed a new nanoparticle that uses a tumor cell's protective mechanism against itself -- short-circuiting tumor cell metabolism and killing tumor cells.

19 Feb 2016

Neuroscientists identify specific enzyme that plays critical role in spinal muscular atrophy

Neuroscientists have discovered a specific enzyme that plays a critical role in spinal muscular atrophy, and that suppressing this enzyme's activity, could markedly reduce the disease's severity and improve patients' lifestyles.

19 Feb 2016

DEK gene present in plasma can help predict outcomes for patients with head and neck cancer

Researchers at the University of Cincinnati have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients. DEK may help doctors understand how a person's immune system could be used to treat cancer or predict outcomes for patients.

18 Feb 2016

Researchers take major step towards developing a cystic fibrosis drug

Researchers from Eindhoven University of Technology and McGill University in Montreal (Canada) have taken an important step towards developing a drug against cystic fibrosis.

18 Feb 2016

Researchers make some progress in determining causes for glioblastoma multiforme

A research team, with the participation of the University of Granada (UGR), has made some progress in determining the causes for glioblastoma multiforme (GBM), one of the most aggressive brain tumors known, to be resistant to the drugs currently used, which is one of the main limitations of its treatment.

18 Feb 2016

Autoantibodies can potentially detect lung cancer at early stage

Preliminary research has identified autoantibodies, immune proteins found in the blood specific for one's own proteins, that can potentially detect lung cancer early by distinguishing between smokers with or without lung cancer and also discriminate between lung cancer and low-dose computed tomography (LDCT) detected non-cancerous lung lesions.

18 Feb 2016

Enzyme screening kits and samples global distribution agreement signed between Strem and Novozymes

Strem Chemicals, Inc., a manufacturer of specialty chemicals for research and development, and Novozymes, the world’s largest producer of industrial enzymes, today announced the signing of a distribution agreement.

17 Feb 2016

Wistar researchers find potential way for using STAT3 inhibitors to stop cancer progression

Imagine developing a drug designed to inhibit a protein that helps cancer cells proliferate and survive only to find that the drug does not perform very well in the clinic. This was the dilemma faced by scientists researching inhibitors of signal transducer and activator of transcription (STAT3), a protein that controls transcription by the STAT3 gene.

17 Feb 2016

Small chemical change to existing antibacterial drug may result in better treatment for TB

Researchers with Vanderbilt University have discovered that one small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis.

17 Feb 2016

Isomaltulose more suitable than table sugar for people with type 2 diabetes

Potsdam-Rehbruecke - Like sucrose (table sugar), the natural disaccharide isomaltulose (PalatinoseTM) consists of glucose and fructose, but it is apparently more suitable for people with type 2 diabetes with regard to regulating blood glucose levels.

17 Feb 2016

Small peptide TAxI holds promise for carrying biologic drugs into spinal cord

A small peptide dubbed TAxI is living up to its name. Recent studies show it to be an effective vehicle for shuttling functional proteins, such as active enzymes, into the spinal cord after a muscle injection.

17 Feb 2016

Study shows new RNA letter as regulatory key to control gene expression

DNA, RNA, protein -- the end. Or is it? Until recently, the pattern used to encode genetic information into our cells was considered to be relatively straightforward: four letters (A,G,C,T) for DNA and four (A,G,C,U) for RNA. This equation, however, turned out to be oversimplified -- RNA was holding out.

17 Feb 2016

Researchers one step closer to developing new treatment strategy to combat TB

By uncovering the 3-dimensional structure of an enzyme that is critical for the survival of the bacterium that cause tuberculosis, researchers may be one step closer to developing a new strategy to combat TB infections.

17 Feb 2016

Research shows how developing neurons use copper for their various needs

Researchers at Johns Hopkins have used a precision sensor in a chicken embryo to find dramatic differences in the use of copper between developing and fully mature neurons.

17 Feb 2016

Study could pave way for new treatment strategies for PKU

Phenylketonuria, also known as PKU, is the most common inherited disease affecting amino acid metabolism. Children are tested for PKU at birth, and babies diagnosed with the disease must adhere to a highly restricted diet to prevent permanent intellectual impairment.

16 Feb 2016

Proof-of-concept data for NanoString's Hyb & Seq chemistry presented at AGBT Meeting

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today presented the first proof-of-concept data for its novel massively parallel single molecule sequencing chemistry, Hyb & Seq™, at the Advances in Genome Biology and Technology Meeting being held in Orlando, Florida.

From NanoString Technologies 16 Feb 2016

Research findings identify potential genetics-guided precision medicine for leukemia patients

An international research team has determined how inherited gene variations lead to severe drug toxicity that may threaten chances for a cure in children with leukemia. St. Jude Children's Research Hospital scientists led the study, results of which set the stage to expand the use of a patient's genetic make-up to tailor chemotherapy.

16 Feb 2016

Critical discovery holds key to explaining how 'good' gut bacteria promote health

A critical discovery about how bacteria feed on an unusual sugar molecule found in leafy green vegetables could hold the key to explaining how 'good' bacteria protect our gut and promote health.

15 Feb 2016

Enzyme News and Research

Researchers analyze how Topo II enzyme may affect stability of genomes

Researchers identify common molecular alteration in glioblastoma

Kellogg investigators develop new nanotechnology that has potential to kill tumor cells in the eye

Neuroscientists identify specific enzyme that plays critical role in spinal muscular atrophy

DEK gene present in plasma can help predict outcomes for patients with head and neck cancer

Researchers take major step towards developing a cystic fibrosis drug

Researchers make some progress in determining causes for glioblastoma multiforme

Autoantibodies can potentially detect lung cancer at early stage

Enzyme screening kits and samples global distribution agreement signed between Strem and Novozymes

Wistar researchers find potential way for using STAT3 inhibitors to stop cancer progression

Small chemical change to existing antibacterial drug may result in better treatment for TB

Isomaltulose more suitable than table sugar for people with type 2 diabetes

Small peptide TAxI holds promise for carrying biologic drugs into spinal cord

Study shows new RNA letter as regulatory key to control gene expression

Researchers one step closer to developing new treatment strategy to combat TB

Research shows how developing neurons use copper for their various needs

Study could pave way for new treatment strategies for PKU

Proof-of-concept data for NanoString's Hyb & Seq chemistry presented at AGBT Meeting

Research findings identify potential genetics-guided precision medicine for leukemia patients

Critical discovery holds key to explaining how 'good' gut bacteria promote health

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