Mutation News and Research

RSS

TSRI researchers discover key proteins involved in one type of DNA repair gone awry

Accumulation of DNA damage can cause aggressive forms of cancer and accelerated aging, so the body's DNA repair mechanisms are normally key to good health. However, in some diseases the DNA repair machinery can become harmful.

23 May 2014

Researchers identify mutation in fat-storage gene that appears to increase risk for type 2 diabetes

Researchers at the University of Maryland School of Medicine have identified a mutation in a fat-storage gene that appears to increase the risk for type 2 diabetes and other metabolic disorders, according to a study published online today in the New England Journal of Medicine.

23 May 2014

Eliminating scar tissue, inflammation may make tumors more deadly, find researchers

New research represents a significant change in the understanding of how pancreatic cancer grows - and how it might be defeated.

23 May 2014

New database allows researchers to match old drugs for new diseases

There are thousands of drugs that silence many thousands of cancer-causing genetic abnormalities. Some of these drugs are in use now, but many of these drugs are sitting on shelves or could be used beyond the disease for which they were originally approved.

23 May 2014

New antibody appears to block sensations of pain, itching in mouse model

Duke University researchers have found an antibody that simultaneously blocks the sensations of pain and itching in studies with mice.

23 May 2014

Separating sperm and eggs from somatic cells preserves genetic building blocks

We have hundreds of types of cells in our bodies - everything from red blood cells to hair follicles to neurons. But why can't most of them create offspring for us?

23 May 2014

Research findings could lead to new approach to Alzheimer’s prevention

In surprise findings, scientists at The Scripps Research Institute have discovered that a protein with a propensity to form harmful aggregates in the body when produced in the liver protects against Alzheimer’s disease aggregates when it is produced in the brain. The results suggest that drugs that can boost the protein’s production specifically in neurons could one day help ward off Alzheimer’s disease.

22 May 2014

Drugs that boost protein's production in neurons could help ward off Alzheimer's disease

In surprise findings, scientists at The Scripps Research Institute (TSRI) have discovered that a protein with a propensity to form harmful aggregates in the body when produced in the liver protects against Alzheimer's disease aggregates when it is produced in the brain.

22 May 2014

Researchers discover key proteins involved in DNA repair gone awry

22 May 2014

Double mastectomies are unnecessary in women with breast cancer, says study

About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive Cancer Center finds

22 May 2014

Erlotinib, gefitinib have similar efficacy in NSCLC patients with EGFR mutation

Disease progression-free survival is similar for patients with non-small-cell lung cancer and epidermal growth factor receptor mutations whether they receive erlotinib or gefitinib, show the results of a South Korean study.

21 May 2014

Supermodel mouse reveals critical role played by unknown gene that regulates metabolism

A lean "Supermodel" mouse type has revealed the potentially critical role played by a largely unknown gene that regulates metabolism, findings that could provide new insight into diseases ranging from diabetes to obesity, a new study by UT-Southwestern Medical Center researchers suggests.

21 May 2014

Genprex initiates Phase II clinical trial of Oncoprex for late-stage lung cancer patients

Genprex, Inc. announced today that it has enrolled the first patient in a clinical trial evaluating its lead product candidate Oncoprex in combination with erlotinib (Tarceva) for late-stage lung cancer patients.

21 May 2014

New compound restores learning, memory and other symptoms of AD in mice

A molecular compound developed by Saint Louis University scientists restored learning, memory and appropriate behavior in a mouse model of Alzheimer's disease, according to findings in the May issue of the Journal of Alzheimer's Disease.

21 May 2014

IL-8 expression predicts lung adenocarcinoma prognosis

Interleukin -8 expression is associated with a poor lung adenocarcinoma prognosis, say Japanese researchers, especially in patients whose tumours are positive for the KRAS mutation.

19 May 2014

Scientists reveal how and why immune system's B cells respond only to true threats

The immune system's B cells protect us from disease by producing antibodies, or "smart bullets," that specifically target invaders such as pathogens and viruses while leaving harmless molecules alone.

16 May 2014

St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide

St. Jude Children's Research Hospital scientists have mapped the structural details of how p53 attaches to its regulatory protein, called BCL-xL, in the cell.

16 May 2014

New dual-pronged approach for treating Niemann-Pick type C disease

By studying nerve and liver cells grown from patient-derived induced pluripotent stem cells (iPSCs), Whitehead Institute researchers have identified a potential dual-pronged approach to treating Niemann-Pick type C (NPC) disease, a rare but devastating genetic disorder.

16 May 2014

Researchers develop potential route to new therapies for treatment of Parkinson's disease

A biologist and a psychologist at the University of York have joined forces with a drug discovery group at Lundbeck in Denmark to develop a potential route to new therapies for the treatment of Parkinson's Disease (PD).

16 May 2014

Researchers test genomic sequencing for women with triple negative breast cancer

Indiana University cancer researchers are testing whether therapy incorporating advanced genomic technology will provide better outcomes than current treatments for those with an aggressive form of breast cancer.

15 May 2014

Mutation News and Research

TSRI researchers discover key proteins involved in one type of DNA repair gone awry

Researchers identify mutation in fat-storage gene that appears to increase risk for type 2 diabetes

Eliminating scar tissue, inflammation may make tumors more deadly, find researchers

New database allows researchers to match old drugs for new diseases

New antibody appears to block sensations of pain, itching in mouse model

Separating sperm and eggs from somatic cells preserves genetic building blocks

Research findings could lead to new approach to Alzheimer’s prevention

Drugs that boost protein's production in neurons could help ward off Alzheimer's disease

Researchers discover key proteins involved in DNA repair gone awry

Double mastectomies are unnecessary in women with breast cancer, says study

Erlotinib, gefitinib have similar efficacy in NSCLC patients with EGFR mutation

Supermodel mouse reveals critical role played by unknown gene that regulates metabolism

Genprex initiates Phase II clinical trial of Oncoprex for late-stage lung cancer patients

New compound restores learning, memory and other symptoms of AD in mice

IL-8 expression predicts lung adenocarcinoma prognosis

Scientists reveal how and why immune system's B cells respond only to true threats

St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide

New dual-pronged approach for treating Niemann-Pick type C disease

Researchers develop potential route to new therapies for treatment of Parkinson's disease

Researchers test genomic sequencing for women with triple negative breast cancer

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

Latest News