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New technique enables high-resolution analysis of DNA

Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science.

4 Aug 2023

Gene expression ratio linked to prognosis in solid tumors

A Ludwig Cancer Research study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.

3 Aug 2023

Researchers discover how aging can lead to chronic metabolic disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

3 Aug 2023

Deep learning improves protein design by 10x

The key to understanding proteins - such as those that govern cancer, COVID-19, and other diseases - is quite simple. Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

3 Aug 2023

Expression of two key genes influences cancer progression

Tissues, blood vessels, cells: tumours develop in a complex ecosystem known as the tumour microenvironment.

3 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

Mothers' diet during pregnancy can protect brain health of children and grandchildren

Mothers who eat apples and herbs in early pregnancy could be protecting the brain health of their children and grandchildren, a Monash University study using genetic models has found.

3 Aug 2023

CAR-T immune therapies could be effective against solid tumors

CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study led by University of Illinois Urbana-Champaign researchers suggests.

3 Aug 2023

Nanoengineered bioink improves tumor model accuracy

Scientists from the Terasaki Institute for Biomedical Innovation have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinting of tumor models.

3 Aug 2023

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

A University of Ottawa-led research team has published rigorous new research that advances a quest to understand a puzzling – and heartbreaking – ultra-rare disease that's found almost exclusively in boys.

3 Aug 2023

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

Innovative 3D cell culture platform could replace the use of animals in research

PeptiMatrix is the latest spin-out company from the University of Nottingham, providing access to an innovative 3D cell culture platform that aims to replace the use of animals in research.

3 Aug 2023

TU Graz researchers gain new insights into a light-activated protein switch

Researchers at TU Graz have gained new insights into the functioning of a protein found in bacteria, whose enzymatic activity is activated by blue light.

3 Aug 2023

Study finds α5 integrin as a potential therapeutic target in amyotrophic lateral sclerosis

Researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral sclerosis (ALS).

3 Aug 2023

Researchers discover cause of cholesteatomas

Chronic inflammation of the middle ear can cause several problems and complications that can affect a person's hearing and balance.

3 Aug 2023

Can light exposure behaviors predict chronotype, sleep quality, mood, memory, and concentration?

Researchers aimed to understand the influences of Light Exposure Behavior Assessment (LEBA) categories on chronotype, mood, sleep quality, memory, and concentration.

3 Aug 2023

Point-of-care rapid diagnostics for detecting SARS-CoV-2 in exhaled breath

Researchers developed a rapid, non-invasive, point-of-care platform for the direct detection of SARS-CoV-2 in exhaled breath.

3 Aug 2023

Study uncovers the science behind the body's tanning process after leaving the beach

Beachgoers are familiar with the experience of spending hours in the sun, going home, and noticing only hours later that their skin has changed color.

3 Aug 2023

UC San Diego team reports new insights on pelvic floor muscle dysfunction

University of California San Diego researchers are leading a team reporting new insights in Science Translational Medicine on pelvic floor muscle (PFM) dysfunction, which is one of the key risk factors for pelvic floor disorders which impact close to a quarter of women in the U.S.

2 Aug 2023

Thymus gland critical for adult health, study finds

The thymus gland - which produces immune T cells before birth and during childhood - is often regarded as nonfunctional in adults, and it's sometimes removed during cardiac surgery for easier access to the heart and major blood vessels.

2 Aug 2023