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Researchers identify six genes with driving mutations in melanoma

It's been a burning question in melanoma research: Tumor cells are full of ultraviolet (UV)-induced genetic damage caused by sunlight exposure, but which mutations drive this cancer? None have been conclusively tied to melanoma. The sheer abundance of these passenger mutations has obscured the search for genetic driver mutations that actually matter in melanoma development and progression.

20 Jul 2012

Single-step method can rapidly detect pathogens and chemical contaminants

Using nanoscale materials, researchers at the University of Georgia have developed a single-step method to rapidly and accurately detect viruses, bacteria and chemical contaminants.

20 Jul 2012

Registered dietitians cut hospital nutrition order errors

Registered dietitians are faster and more accurate than other hospital staff when entering physician-approved nutrition-related orders, show study findings.

19 Jul 2012

Statistical method uses evolutionary information to enhance identification of disease-associated alleles

A book containing misprints may cause annoyance for the reader, but typos in an individual's genetic blueprint (DNA) can mean serious disease or even death. The search for genetic correlates for the wide range of diseases plaguing humankind has inspired a wealth of research falling under the heading of genome-wide association studies (GWAS).

19 Jul 2012

A quarter of patients admitted to Scottish ICUs have alcohol problems

A quarter of patients admitted to Scottish intensive care units have alcohol problems and the majority of those have chronic alcohol disease, with particular problems among men and younger people.

19 Jul 2012

Alcohol and marijuana use predict hookah initiation, frequency

Nearly a quarter of college women try smoking tobacco with a hookah, or water pipe, for the first time during their freshman year, according to new research from The Miriam Hospital's Center for Behavioral and Preventive Medicine.

19 Jul 2012

Positive preliminary results from Feraheme phase III study on iron deficiency anemia

AMAG Pharmaceuticals, Inc. today reported preliminary results from the second phase III study from its global registrational program for Feraheme (ferumoxytol) in patients with iron deficiency anemia (IDA) regardless of the underlying cause.

19 Jul 2012

High vitamin E intake associated with reduced risk of liver cancer

High consumption of vitamin E either from diet or vitamin supplements may lower the risk of liver cancer, according to a study published July 17 in the Journal of the National Cancer Institute.

19 Jul 2012

Nerve growth factors sense OAB in children

Researchers may have found a reliable biomarker for diagnosing overactive bladder in children and monitoring their treatment outcome.

18 Jul 2012

Silymarin does not provide greater benefit for patients with chronic HCV infection

Use of the botanical product silymarin, an extract of milk thistle that is commonly used by some patients with chronic liver disease, did not provide greater benefit than placebo for patients with treatment-resistant chronic hepatitis C virus (HCV) infection, according to a study in the July 18 issue of JAMA.

18 Jul 2012

Why is the incidence of gout increasing?

Gout has been described by the Daily Mail as something, “usually associated with port-swilling, over-fed elderly men of the 19th century”. (1) Recent research carried out at the Boston University School of Medicine, however, has found that the incidence of gout in the US is on the rise. (2) Thus, the condition is clearly not something that only affects this stereotype.

17 Jul 2012

New NMR spectrometer to benefit researchers from across Texas A&M

Top-notch molecular research swung into gear at Texas A&M University this week - literally. A crane lowered a high-field 800 megahertz Nuclear Magnetic Resonance spectrometer through an opening in the roof of a biochemistry and biophysics building Wednesday, putting the university on par with leading U.S. research institutions, according to Dr. Gregory Reinhart, department head.

16 Jul 2012

Migraine involves multiple symptoms that vary widely among sufferers

Almost everyone suffers from headache pain occasionally, but for 36 million Americans, intense, debilitating headaches accompanied by other neurological symptoms — also known as migraine syndrome — are a source of physical misery that can have a devastating effect on their quality of life. It is estimated that the medical expenses and loss of productivity caused by migraine costs Americans $20 billion annually.

14 Jul 2012

Infants with food allergies exhibit high rate of reactions over time

Infants with documented or likely milk or egg allergies experience a high number of reactions caused by accidental and nonaccidental exposure, results of a three-year observational study demonstrate.

13 Jul 2012

OncoMed commences dosing in OMP-54F28 Phase I clinical trial for advanced solid tumor cancers

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells, or tumor-initiating cells, today announced that patient dosing has begun in a Phase I clinical trial of OMP-54F28 in patients with advanced solid tumor cancers.

13 Jul 2012

Abused children may become obese adults

Severity of abuse in childhood or adolescence is associated with an increased risk for overall and central obesity in adulthood, report researchers.

12 Jul 2012

Nottingham researchers to lead Avastin clinical study for AMD

Nottingham researchers are leading a study to test the effectiveness of a controversial drug in the treatment of a common loss of vision.

12 Jul 2012

Victims of stray-bullet shootings are often children, females

Most people killed or wounded in stray-bullet shootings were unaware of events leading to the gunfire that caused their injuries, and nearly one-third of the victims were children and nearly half were female, according to a new nationwide study examining an often-overlooked form of gun violence.

11 Jul 2012

Euthanasia and assisted suicide rates in the Netherlands comparable to rates before legalisation

2010 rates of euthanasia and assisted suicide in the Netherlands were comparable to levels before the practices were legalised in 2002, according to new research published Online First in The Lancet and conducted by a Dutch research team from Erasmus MC University Medical Centre, Rotterdam; VU University Medical Centre, Amsterdam; Statistics Netherlands, The Hague; and Utrecht’s University Medical Centre.

11 Jul 2012

HIV and AIDS treatment: An interview with Charles Flexner, MD

The best estimates at the moment reckon that there are about 25 million people infected with HIV. Most of those are in resource-limited settings, including sub-Saharan Africa, South East Asia and India.

11 Jul 2012