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Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Merck, known as MSD outside the United States and Canada, announced today that the pivotal Phase 3 KEYNOTE-048 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma, met a primary endpoint of overall survival as monotherapy in patients whose tumors expressed PD-L1.

25 Jul 2018

Researchers discover how antibodies secreted in the gut promote growth of healthy microbiome

Researchers at the RIKEN Center for Integrative Medical Science in Japan have discovered how antibodies secreted in the gut promote the growth of beneficial bacteria.

25 Jul 2018

New research uncovers AEP enzyme's importance to immunity

The importance of the enzyme AEP as a key regulatory of the immune system has been discovered in new research from Newcastle University, UK.

24 Jul 2018

Researchers find that IgM antibody could protect against HIV-1

A team of scientists from Texas Biomedical Research Institute have homed in on an antibody that could protect against infection with HIV-1.

24 Jul 2018

New applications for high-throughput flow cytometry in drug discovery

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry in drug discovery.

24 Jul 2018

Study reveals protective potential of new class of antibodies against HIV-1 infection

A group of scientists at Texas Biomedical Research Institute have zeroed in on a new defense against HIV-1, the virus that causes AIDS. Led by Ruth Ruprecht, M.D., Ph.D., the team used an animal model to show for the first time that an antibody called Immunoglobulin M was effective in preventing infection after mucosal AIDS virus exposure.

24 Jul 2018

ECU researchers develop world’s first blood test that detects melanoma in its early stages

Edith Cowan University researchers have developed the world’s first blood test capable of detecting melanoma in its early stages, a breakthrough that will save thousands of lives, as well as millions of dollars for the health system.

20 Jul 2018

Using miniature drug-filled nanocarriers to target headaches and tumors

Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors.

20 Jul 2018

FAU researchers find possible cause of Parkinson’s disease in the patients’ immune system

Parkinson's disease, formerly also referred to as shaking palsy, is one of the most frequent disorders affecting movement and the nervous system.

19 Jul 2018

Study uncovers new protein complex that shields broken DNA ends

Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for the treatment of cancer.

19 Jul 2018

Melanoma could soon be detected using a blood test

West Australian researchers from Edith Cowan University have managed to develop a blood test that is capable of diagnosing melanomas before they can spread to other parts of the body. The study titled, “A diagnostic autoantibody signature for primary cutaneous melanoma,” was published in the latest issue of the journal Oncotarget.

18 Jul 2018

Researchers detect presence of IgE antibodies after kidney transplantation

Many donor kidneys that are transplanted are rejected by the recipient within ten years after transplantation.

17 Jul 2018

New study suggests testing urine and blood serum as better way to diagnose myeloma

When it comes to diagnosing a condition in which the plasma cells that normally make antibodies to protect us instead become cancerous, it may be better to look at the urine as well as the serum of our blood for answers, pathologists say.

13 Jul 2018

Researchers find new way for producing medical therapeutic proteins

Bacterial systems are some of the simplest and most effective platforms for the expression of recombinant proteins.

13 Jul 2018

New clinical trial to evaluate virotherapy and immunotherapy combination for ovarian, colorectal cancers

Ludwig Cancer Research and the Cancer Research Institute announce the initiation of a clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI (durvalumab) for advanced ovarian and colorectal cancers.

12 Jul 2018