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Gilenya offers more benefits for MS therapy than previously realized

In September, patients suffering from multiple sclerosis (MS) received the welcome news that the U.S. Food and Drug Administration (FDA) had approved a promising new drug for their condition called Gilenya. Now, a team from The Scripps Research Institute has discovered that this drug's success may involve an unexpected biological mechanism acting within the central nervous system (CNS). This difference may mean that Gilenya offers even more benefits than previously realized and would represent the first MS therapy with direct CNS activities.

21 Dec 2010

Wellcome Trust awards additional £390,000 for investigation of Allergen Delivery Inhibitors

Scientists at St George's, University of London and the University of Manchester have received an additional Seeding Drug Discovery award of £390,000 from the Wellcome Trust to explore a new class of experimental drugs that block the trigger of allergic reactions before symptoms show.

21 Dec 2010

Study reveals novel role of adenosine signaling in sickle cell disease

Metabolon, Inc., the leader in metabolomics, biomarker discovery and analysis, announces the publication of "Novel Role of Adenosine Signaling in Sickle Cell Disease", in Nature Medicine. Application of non-targeted biochemical profiling (metabolomics) to a mouse model of sickle cell disease (SCD) revealed a detrimental role of adenosine signaling in SCD and suggested novel therapeutic targets. The study was carried out in collaboration with The University of Texas Health Science Center at Houston.

21 Dec 2010

Use of metaphors may help doctors to recruit low-income people for cancer clinical trials

The language that doctors use with low-income, rural patients can help determine whether these patients agree to participate in clinical trials testing new cancer treatments, a new study found.

21 Dec 2010

DNA sequence variations linked with heart's electrical rhythm in several surprising regions

A study among almost 50,000 people worldwide has identified DNA sequence variations linked with the heart's electrical rhythm in several surprising regions among 22 locations across the human genome. The variants were found by an international consortium, including Johns Hopkins researchers, and reported Nov. 14 in the Nature Genetics advance online publication.

21 Dec 2010

Recent study finds racial and ethnic minority smokers of menthol cigarettes have lower quit rate

Menthol cigarettes may be harder to quit, particularly for some teens and African-Americans, who have the highest menthol cigarette use, according to a study by a team of researchers.

21 Dec 2010

Amylin submits metreleptin rolling submission BLA for treatment of rare forms of lipodystrophy

Amylin Pharmaceuticals, Inc. today announced that it has submitted the initial sections of a rolling submission for a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for the use of metreleptin to treat diabetes and/or hypertriglyceridemia (high levels of triglycerides in the bloodstream) in patients with rare forms of lipodystrophy.

21 Dec 2010

Wishard expands partnership with SIS to improve perioperative services

Wishard Health Services has expanded its partnership with Surgical Information Systems by adding anesthesia, business intelligence and patient tracking capabilities to its existing SIS perioperative system.

21 Dec 2010

New research sheds light on complex regulatory pathways for effective innate immune system

New research by scientists at the University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences reveals that the immune system has an effective backup plan to protect the body from infection when the "master regulator" of the body's innate immune system fails.

21 Dec 2010

Lilly Endowment grants funds to Manchester College to establish School of Pharmacy

A small Midwest college that is producing alumni with sizeable reputations in the science world has received a $35 million grant from Lilly Endowment to launch a School of Pharmacy.

21 Dec 2010

New predictive medicine product for hereditary pancreatic and related cancers

Myriad Genetics, Inc. today announced the launch of PANEXIA™, a predictive medicine product for hereditary pancreatic and related cancers. PANEXIA is a comprehensive analysis of the PALB2 and BRCA2 genes for assessing a person's risk of developing pancreatic cancer later in life. PANEXIA, Myriad's ninth molecular diagnostic product, is the second product launched by the Company this year.

21 Dec 2010

Researchers develop new lung imaging technique that causes minimum tissue disruption

Fast-moving objects create blurry images in photography, and the same challenge exists when scientists observe cellular interactions within tissues constantly in motion, such as the breathing lung. In a recent UCSF-led study in mice, researchers developed a method to stabilize living lung tissue for imaging without disrupting the normal function of the organ.

21 Dec 2010

Positive results from Incyte's COMFORT-I INCB18424 pivotal Phase III clinical trial in myelofibrosis

Incyte Corporation announced today positive top-line results from COMFORT-I, the pivotal Phase III clinical trial of INCB18424 (also known as INC424) in patients with myelofibrosis (MF) being conducted under a Food and Drug Administration (FDA) Special Protocol Assessment (SPA) Agreement. COMFORT-I (COntrolled MyeloFibrosis Study with ORal JAK Inhibitor Treatment) is a double-blind, placebo-controlled Phase III trial involving 309 patients.

21 Dec 2010

Biogen Idec acquires Neurimmune subsidiary

Biogen Idec and Neurimmune Holding AG today announced that Biogen Idec has acquired a subsidiary of Neurimmune, which includes the world-wide rights to three pre-clinical immunotherapy programs. The three programs are focused on the discovery and development of novel human antibodies that address three central nervous system (CNS) targets: alpha-synuclein, tau and TDP-43.

21 Dec 2010

Treatment with acid-suppressive drugs associated with increased risk of pneumonia

Using acid suppressive medications, such as proton pump inhibitors and histamine2 receptor antagonists, may increase the risk of developing pneumonia, states an article in CMAJ (Canadian Medical Association Journal).

21 Dec 2010

Echinacea may have minimal impact in relieving common cold

An over-the-counter herbal treatment believed to have medicinal benefits has minimal impact in relieving the common cold, according to research by the University of Wisconsin-Madison School of Medicine and Public Health.

21 Dec 2010

Exome sequencing leads to correct diagnosis and life-saving treatment for mysterious genetic disorder

A genetic testing approach called exome sequencing—which provides a clinically practical alternative to whole-genome sequencing—led to correct diagnosis and life-saving treatment in a child with a previously unknown genetic disease, reports an upcoming paper in Genetics in Medicine, the official peer-reviewed journal of The American College of Medical Genetics (ACMG). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

21 Dec 2010

Proteins that unlock the mystery of over 100 brain diseases

An Anglo-American team of researchers have made a medical breakthrough after identifying a large collection of nerve proteins that are involved in around 130 brain diseases including Alzheimer’s and autism.

20 Dec 2010

Wolters Kluwer Health announces completion of Pharmacy OneSource acquisition

Wolters Kluwer Health, a leading provider of information and business intelligence for professionals, students and institutions in medicine, nursing, allied health and pharmacy, today announced it has completed the acquisition of Pharmacy OneSource, a leading Software-as-a-Service (SaaS) provider in the hospital pharmacy market. The agreement to acquire Pharmacy OneSource was announced on November 29, 2010.

20 Dec 2010

Opsens unveils EasyWire for growth market of Fractional Flow Reserve for coronary lesion assessment

Opsens Inc. today unveiled the EasyWire, developed by its medical division for the growth market of Fractional Flow Reserve for coronary lesion assessment.

20 Dec 2010

Medicine News and Research

Gilenya offers more benefits for MS therapy than previously realized

Wellcome Trust awards additional £390,000 for investigation of Allergen Delivery Inhibitors

Study reveals novel role of adenosine signaling in sickle cell disease

Use of metaphors may help doctors to recruit low-income people for cancer clinical trials

DNA sequence variations linked with heart's electrical rhythm in several surprising regions

Recent study finds racial and ethnic minority smokers of menthol cigarettes have lower quit rate

Amylin submits metreleptin rolling submission BLA for treatment of rare forms of lipodystrophy

Wishard expands partnership with SIS to improve perioperative services

New research sheds light on complex regulatory pathways for effective innate immune system

Lilly Endowment grants funds to Manchester College to establish School of Pharmacy

New predictive medicine product for hereditary pancreatic and related cancers

Researchers develop new lung imaging technique that causes minimum tissue disruption

Positive results from Incyte's COMFORT-I INCB18424 pivotal Phase III clinical trial in myelofibrosis

Biogen Idec acquires Neurimmune subsidiary

Treatment with acid-suppressive drugs associated with increased risk of pneumonia

Echinacea may have minimal impact in relieving common cold

Exome sequencing leads to correct diagnosis and life-saving treatment for mysterious genetic disorder

Proteins that unlock the mystery of over 100 brain diseases

Wolters Kluwer Health announces completion of Pharmacy OneSource acquisition

Opsens unveils EasyWire for growth market of Fractional Flow Reserve for coronary lesion assessment

Everything there is to know about biosimilars eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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