Mutation News and Research

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Detection of genetic abnormalities could improve effectiveness of colon cancer screening

A non-invasive test that includes detection of the genetic abnormalities related to cancer could significantly improve the effectiveness of colon cancer screening, according to research published by a team of scientists including David Ransohoff, MD, professor of medicine at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center member.

20 Mar 2014

Trimethoprim is more effective against streptococci than expected, says research

The focus of his team was also on samples, in which the bacteria failed to respond to the agent. They discovered two types of resistance. "Spontaneous mutations can occur in the gene for dihydrofolate reductase rendering trimethoprim no longer able to attack the changed enzyme, which means it becomes ineffective," Nitsche-Schmitz explained.

20 Mar 2014

Archaeologists find oldest complete example of metastatic cancer in 3,000 year-old skeleton

Archaeologists have found the oldest complete example in the world of a human with metastatic cancer in a 3,000 year-old skeleton.

19 Mar 2014

Findings open way to identification of new cancer drugs to fight acute myeloid leukemia

The Institute for Research in Immunology and Cancer (IRIC) at the Université de Montréal (UdeM), in collaboration with the Maisonneuve-Rosemont Hospital's Quebec Leukemia Cell Bank, recently achieved a significant breakthrough thanks to the laboratory growth of leukemic stem cells, which will speed up the development of new cancer drugs.

18 Mar 2014

Researchers examine how diabetes drug can benefit cancer patients

For several years, a class of anti-diabetic drugs known as biguanides, has been associated with anti-cancer properties. A number of retrospective studies have shown that the widely used diabetes drug metformin can benefit some cancer patients.

18 Mar 2014

Compound from "third-hand smoke" damages DNA and potentially cause cancer

Leftover cigarette smoke that clings to walls and furniture is a smelly nuisance, but now research suggests that it could pose a far more serious threat, especially to young children who put toys and other smoke-affected items into their mouths.

18 Mar 2014

Rice University technique able to analyze conformations of complex molecular machines

Open, feed, cut. Such is the humdrum life of a motor molecule, the subject of new research at Rice University, that eats and excretes damaged proteins and turns them into harmless peptides for disposal.

18 Mar 2014

Trovagene reports net loss of $1 million for fourth quarter 2013

Trovagene, Inc., a developer of cell-free molecular diagnostics, today reported its financial results for the quarter and the year ended December 31, 2013.

18 Mar 2014

Dampened reward response tied to schizophrenia risk

The striatal hypoactivation during reward anticipation seen in patients with schizophrenia is also present in their unaffected first-degree relatives, research shows.

17 Mar 2014

Findings reveal potential drug targets for small cell lung cancer

Cancer cells undergo extensive genetic alterations as they grow and spread through the body. Some of these mutations, known as "drivers," help spur cells to grow out of control, while others ("passengers") are merely along for the ride.

17 Mar 2014

Findings reveal that miR-34 genes are bona fide tumor suppressors

Cornell University researchers report they have discovered direct genetic evidence that a family of genes, called MicroRNA-34 (miR-34), are bona fide tumor suppressors.

17 Mar 2014

Scientists discover key mechanism that guides balance and limb movements

Scientists at The Scripps Research Institute (TSRI) have discovered an important mechanism underlying sensory feedback that guides balance and limb movements.

17 Mar 2014

Scientists discover important mechanism for muscle building

In order to move the body, skeletal muscles are pulling on the skeleton. For efficient muscle and skeletal movements it is essential that the muscle contracts only along a defined axis, for instance for the leg movement along the thigh.

17 Mar 2014

FDA grants Fast Track designation to Edison’s lead drug EPI-743

Edison Pharmaceuticals today announced that the United States Food and Drug Administration granted Fast Track designation to EPI-743, the company's lead drug, for the treatment of Friedreich's ataxia. EPI-743 is being developed for pediatric and adult mitochondrial disease, including Friedreich's ataxia.

17 Mar 2014

Researchers identify novel protein that explains how biological clocks regulate human sleep

In a series of experiments sparked by fruit flies that couldn't sleep, Johns Hopkins researchers say they have identified a mutant gene - dubbed "Wide Awake" - that sabotages how the biological clock sets the timing for sleep.

17 Mar 2014

Researchers discover USP9X gene that sheds new light on mysteries of brain development, disability

Research from the University of Adelaide has confirmed that a gene linked to intellectual disability is critical to the earliest stages of the development of human brains.

17 Mar 2014

Researchers identify two novel genes associated with development of rare, aggressive blood cancer

Researchers have identified two novel cancer genes that are associated with the development of a rare, highly aggressive, cancer of blood vessels. These genes may now act as markers for future treatments and explain why narrowly targeted therapies that are directed at just one target fail.

17 Mar 2014

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

13 Mar 2014

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by University of Maryland School of Public Health researchers.

13 Mar 2014

EPFL sets up foundation to release antibiotic for tuberculosis

Even though tuberculosis kills more than 1.5 million people every year, the market is not cost-effective for pharmaceutical companies. So EPFL is setting up a foundation to release an antibiotic developed in its own laboratories under EU funding.

12 Mar 2014

Mutation News and Research

Detection of genetic abnormalities could improve effectiveness of colon cancer screening

Trimethoprim is more effective against streptococci than expected, says research

Archaeologists find oldest complete example of metastatic cancer in 3,000 year-old skeleton

Findings open way to identification of new cancer drugs to fight acute myeloid leukemia

Researchers examine how diabetes drug can benefit cancer patients

Compound from "third-hand smoke" damages DNA and potentially cause cancer

Rice University technique able to analyze conformations of complex molecular machines

Trovagene reports net loss of $1 million for fourth quarter 2013

Dampened reward response tied to schizophrenia risk

Findings reveal potential drug targets for small cell lung cancer

Findings reveal that miR-34 genes are bona fide tumor suppressors

Scientists discover key mechanism that guides balance and limb movements

Scientists discover important mechanism for muscle building

FDA grants Fast Track designation to Edison’s lead drug EPI-743

Researchers identify novel protein that explains how biological clocks regulate human sleep

Researchers discover USP9X gene that sheds new light on mysteries of brain development, disability

Researchers identify two novel genes associated with development of rare, aggressive blood cancer

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

EPFL sets up foundation to release antibiotic for tuberculosis

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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