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People without heart disease symptoms should use caution in obtaining cardiac imaging exams

At the radiation dose levels used in cardiac imaging exams, such as cardiac CT or nuclear medicine scans, the risk of potentially harmful effects from ionizing radiation are low.

2 Feb 2009

Sedative dexmedetomidine may offer advantages over agents often used for sedation in ICU

Use of the sedative dexmedetomidine for critically ill patients resulted in less time on a ventilator and less delirium compared to patients administered a more commonly used drug, according to a study in the February 4 issue of JAMA, the Journal of the American Medical Association.

2 Feb 2009

Improved strategies to tackle ghostwriting in the medical literature

Better strategies to tackle ghostwriting in the medical literature are the subject of a debate by leading authors in next week's issue of the open-access journal PLoS Medicine.

2 Feb 2009

A framework for major depressive disorder

Genes, psychological adversity in childhood, and recent or ongoing psychological stress may combine to cause major depression, write Dr. Sanjay Mathew and colleagues from Mount Sinai School of Medicine in New York in a review published in CMAJ.

2 Feb 2009

Gene expression signature associated with survival in advanced ovarian cancer

A new study published this week in the open-access journal PLoS Medicine identifies molecular pathways associated with outcomes in ovarian cancer.

2 Feb 2009

Combined measures of maternal drinking can predict resulting problems in children

While many people are aware that drinking during pregnancy can lead to a range of Fetal Alcohol Spectrum Disorders (FASDs), including the serious Fetal Alcohol Syndrome (FAS), linkages between maternal-drinking measures and child outcomes have been inconsistent.

2 Feb 2009

Cell-building discovery offers great potential for basic cell biology, drug and tissue research

Brown University biomedical engineers can now grow and assemble living microtissues into complex three-dimensional structures in a way that will advance the field of tissue engineering and may eventually reduce the need for certain kinds of animal research.

2 Feb 2009

Vitamin and mineral supplement use high among U.S. children and teens

A large number of U.S. children and teens age 2 to 17 appear to use vitamin and mineral supplements, although most may not need them, according to a report in the February issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

2 Feb 2009

Distrust of medical research more common among African American parents

Distrust of medical research appears more common among African American parents than white parents and may present a barrier to enrollment of minority children in research studies, according to a report in the February issue of Archives of Pediatrics & Adolescent Medicine.

2 Feb 2009

The state of America's health care is poor

"The state of America's health care is poor," Jeffrey P. Harris, MD, FACP, president of the American College of Physicians (ACP), reported today at the annual State of the Nation's Health Care briefing.

2 Feb 2009

Stereotactic vacuum-assisted breast needle biopsy better than 14-gauge in breast biopsy

Stereotactic vacuum-assisted breast needle biopsy, a common minimally invasive biopsy method used in the US, is more effective with an 11-gauge needle than the 14-gauge needle decreasing a physician's chances of false-negative diagnoses, according to a study performed at the Stanford University School of Medicine in Stanford, CA.

2 Feb 2009

New potential targets for colitis-associated cancer

Recent research from the laboratory of Michael Karin, PhD, at the University of California, San Diego School of Medicine - the first researcher to demonstrate a molecular link between inflammation and cancer - has identified two potential targets for the prevention and treatment of colitis-associated cancer (CAC), the most serious complication of inflammatory bowel disease.

2 Feb 2009

The end of sex as we once knew it

Women are not from Venus any more than men are from Mars. But even though both sexes are perfectly terrestrial beings, they are not lacking in other differences. And not only in their reproductive organs and behavior, either, but in such unsexy characteristics as the propensity for drug abuse, fine motor control, reaction to stress, moods and many brain structures.

2 Feb 2009

Surgeons remove healthy kidney through donor's vagina

In what is believed to be a first-ever procedure, surgeons at Johns Hopkins have successfully removed a healthy donor kidney through a small incision in the back of the donor's vagina.

2 Feb 2009

New insights into growth factor's role in brain development

New research sheds light on a neural growth factor called proBDNF, finding that it is present and potentially active during the perinatal period when the brain's circuitry and memory-encoding regions are being refined.

2 Feb 2009

Weight loss in overweight and obese women reduces urinary incontinence

Reducing urinary incontinence can now be added to the extensive list of health benefits of weight loss, according to a clinical trial funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Research on Women's Health (ORWH), both part of the National Institutes of Health (NIH).

2 Feb 2009