Clinical Trial News and Research

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New molecule offers a promising avenue to treat triple-negative breast cancer

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer - a form of cancer that is notoriously aggressive and lacks effective treatments.

7 Nov 2025

Supervised training boosts muscle mass and balance in advanced breast cancer patients

Aerobic and resistance exercise can significantly improve physical performance in patients living with metastatic breast cancer according to new results presented at the Advanced Breast Cancer Eighth International Consensus Conference (ABC8) today (Friday).

6 Nov 2025

Over-the-counter pain relievers outperform opioids after wisdom tooth extraction

Over-the-counter pain medications work as well or better than opioids after wisdom tooth extraction for both men and women, according to a Rutgers Health-led follow-up to a landmark paper on comparative pain relief.

6 Nov 2025

Long-term study shows peanut patch treatment builds tolerance in toddlers

New research presented at the 2025 Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) offers encouraging news for parents of young children with peanut allergies.

6 Nov 2025

Novel therapy for psychosis tackles disturbing mental imagery

A pioneering therapy targeting distressing and disturbing mental images for people with psychosis could lead to a transformative intervention for a condition estimated to cost England almost £12 billion a year.

6 Nov 2025

Experimental intranasal vaccine triggers broad immune response against multiple strains of H5N1

Researchers at the University of Maryland School of Medicine's Center for Vaccine Development and Global Health (CVD) reported encouraging results from an early phase clinical trial that found an experimental intranasal vaccine triggered a broad immune response against multiple strains of H5N1 "bird flu".

6 Nov 2025

Global report reveals a decade of uneven progress in advanced breast cancer care

The ABC Global Alliance today launched the Advanced Breast Cancer (ABC) Global Decade Report 2015–2025 - a landmark global assessment revealing a decade of remarkable scientific progress that has transformed ABC care for some patients in some countries, while many others around the world have yet to benefit.

5 Nov 2025

Radiotherapy may be unnecessary for many breast cancer patients after mastectomy

Radiotherapy can be safely omitted as a treatment for many breast cancer patients who have had a mastectomy and are taking anti-cancer drugs, a study shows.

5 Nov 2025

NYU Langone Health begins first clinical trial of gene-edited pig kidney transplants

The first surgery in a clinical trial testing the safety and efficacy of gene-edited pig kidney transplants in patients with end-stage renal disease was recently performed at NYU Langone Health.

5 Nov 2025

New analysis identifies safer treatment paths for children with medulloblastoma

By analyzing data from three clinical trials treating children with the brain tumor medulloblastoma, scientists at St. Jude Children's Research Hospital have designed an approach to safely reduce therapy, thereby lowering side effects.

5 Nov 2025

Rituximab shows remarkable success in adults with relapsing nephrotic syndrome

One monoclonal antibody, rituximab, can work wonders for the treatment of children with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome.

5 Nov 2025

Top-five pharmaceutical company expands partnership with Aptamer for multi-target Optimer® development program

Aptamer Group plc, the developer of next-generation synthetic binders for the life sciences industry, today announced a new contract valued at up to £617,000 with a top-five pharmaceutical company.

4 Nov 2025

Breakthrough research offers first targeted treatment option for NRAS-mutant melanoma

New research from Moffitt Cancer Center shows that RAS(ON) multi-selective inhibition can directly block tumor growth and activate the immune system, offering the first targeted approach for patients with NRAS-mutant melanoma, an aggressive form of skin cancer with limited treatment options beyond immune checkpoint inhibitors.

4 Nov 2025

New initiative aims to accelerate aortic stenosis diagnosis and treatment

People living with aortic stenosis (AS) could gain earlier access to innovative care and treatment thanks to a new effort from the American Heart Association designed to boost clinical trial participation and speed diagnosis of this common but underdiagnosed heart valve condition.

4 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025

Flexible drug-delivery patch can promote tissue healing after a heart attack

MIT engineers have developed a flexible drug-delivery patch that can be placed on the heart after a heart attack to help promote healing and regeneration of cardiac tissue.

4 Nov 2025

Familiar voices help reduce the risk of delirium in ICU patients

The innovative use of recorded messages from a family member to provide reorientation information to a critically ill patient receiving mechanical ventilation helped reduce the risk of developing delirium, according to new research published in American Journal of Critical Care (AJCC).

3 Nov 2025

Low-dose aspirin helps reduce the incidence of major cardiovascular event among diabetic individuals

People with Type 2 diabetes (T2D) and an elevated risk for cardiovascular disease (CVD) who took low-dose aspirin were less likely to experience a major cardiovascular event, including heart attack, stroke or death, than people with T2D at similar CVD risk who did not take low-dose aspirin, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2025.

3 Nov 2025

Research shows citrus and grape compounds may protect against type 2 diabetes

A six-month clinical trial found that a supplement combining citrus and grape extracts, hesperidin, and chromium significantly reduced fasting blood glucose in prediabetic adults. Participants also saw improved cholesterol and triglyceride levels, returning many to normal metabolic health.

2 Nov 2025

Sirolimus-eluting balloon emerges as a safe and effective option for coronary in-stent restenosis

A new drug-eluting balloon can perform just as well as the standard treatment for patients with coronary in-stent restenosis (ISR) undergoing repeated percutaneous coronary intervention (PCI).

31 Oct 2025

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Clinical Trial News and Research

New molecule offers a promising avenue to treat triple-negative breast cancer

Supervised training boosts muscle mass and balance in advanced breast cancer patients

Over-the-counter pain relievers outperform opioids after wisdom tooth extraction

Long-term study shows peanut patch treatment builds tolerance in toddlers

Novel therapy for psychosis tackles disturbing mental imagery

Experimental intranasal vaccine triggers broad immune response against multiple strains of H5N1

Global report reveals a decade of uneven progress in advanced breast cancer care

Radiotherapy may be unnecessary for many breast cancer patients after mastectomy

NYU Langone Health begins first clinical trial of gene-edited pig kidney transplants

New analysis identifies safer treatment paths for children with medulloblastoma

Rituximab shows remarkable success in adults with relapsing nephrotic syndrome

Top-five pharmaceutical company expands partnership with Aptamer for multi-target Optimer® development program

Breakthrough research offers first targeted treatment option for NRAS-mutant melanoma

New initiative aims to accelerate aortic stenosis diagnosis and treatment

GLP-1 drugs calm inflammation beyond diabetes and weight loss

Flexible drug-delivery patch can promote tissue healing after a heart attack

Familiar voices help reduce the risk of delirium in ICU patients

Low-dose aspirin helps reduce the incidence of major cardiovascular event among diabetic individuals

Research shows citrus and grape compounds may protect against type 2 diabetes

Sirolimus-eluting balloon emerges as a safe and effective option for coronary in-stent restenosis

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