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Bacteria play specific roles in cancer

In a recent article published in the journal Immunity, the authors discussed the findings from a 2022 study by Galeano Niño et al., which reported that microbiota associated with tumors form micro-niches and play a role in epithelial and immune mediations of cancer.

12 Jan 2023

Immunotherapy prior to surgery strikingly effective for patients with colorectal cancer

New research in the January 2023 issue of JNCCN - Journal of the National Comprehensive Cancer Network finds that immunotherapy from immune checkpoint (PD-1) inhibitors prior to surgery was strikingly effective for patients with localized mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC).

12 Jan 2023

Orally administered insulin tablet powered by chemical micromotors

For the millions of people living with diabetes, insulin is a life-saving drug. Unlike many other medicines, though, insulin cannot be easily delivered by swallowing a pill - it needs to be injected under the skin with a syringe or pump.

9 Jan 2023

Current research on gut microbial modulation with culinary herbs and spices

An article published in Food Chemistry elaborated on the health benefits of culinary herbs and spices.

5 Jan 2023

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Many public health warnings have been issued against alcohol consumption, even in small quantities, though the evidence for such strict limits is controversial. The current study, published in the MDPI journal Nutrients, is a narrative review focused on clearing up some of the confusion associated with alcoholic drinks.

4 Jan 2023

The metabolic links between diet-induced changes in the gut and NASH

Scientists reviewed the metabolic association between diet-induced alterations in the gut and NASH

4 Jan 2023

Innovations in expansion microscopy allow unprecedented view of the interior of cells

Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to innovations in expansion microscopy.

2 Jan 2023

Study reveals a previously unappreciated complexity of TRM cell biology in the gut

Recent pressure to maximize vaccine efficacy has stirred up many new discoveries within immunology, revealing numerous paradigms with untapped therapeutic potential.

28 Dec 2022

AI can improve the effectiveness of colonoscopy in the presence of Lynch syndrome

First study of AI-assisted colonoscopy for colorectal cancer surveillance in patients with genetic predisposition - People with Lynch syndrome have a higher hereditary risk of colon cancer.

28 Dec 2022

When it comes to harvesting energy, some guts do it better than others

New research from the University of Copenhagen suggests that a portion of the Danish population has a composition of gut microbes that, on average, extracts more energy from food than the microbes in their fellow Danes' guts.

25 Dec 2022

High ammonia levels lead to fewer T cells and immunotherapy resistance in colorectal cancer

High levels of ammonia in tumors lead to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed.

23 Dec 2022

Targeting Piezo2 could provide new avenue for treating chronic pain related to gastrointestinal disorders

Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.

23 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

Researchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules.

21 Dec 2022

Huge multi-omic data analysis deciphers colorectal cancer genetics

An analysis of more than 100,000 colorectal cancer cases and 154,000 healthy controls published in Nature Genetics uncovered hundreds of signals that may serve as new treatment and prevention targets.

21 Dec 2022

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models, according to a new study by Weill Cornell Medicine investigators.

16 Dec 2022

Colorectal cancer doesn’t wait - DNA methylation tests facilitate earlier treatment

In this interview, Yantao Li and Zhe Wang, Director of Cancer Early Screening Products and the Product Director of Oncology at BGI Genomics, talks to NewsMedical about colorectal cancer (CRC), including why incidences are important and the importance of screening.

From BGI Genomics 6 Dec 2022

Does irritable bowel syndrome result from gravity?

New research discussed the hypothesis that irritable bowel syndrome (IBS) may result from gravity.

5 Dec 2022

How two structurally different lemon pectins modulate the gut microbiota

A diet containing fruits and vegetables contains pectins (plant polysaccharides). Pectin cannot be metabolized by mammalian cells in the gastrointestinal tract but is fermented by the gut microbiota in the colon, where short-chain fatty acids (SCFAs) are released. Previous studies have examined pectin's prebiotic properties.

4 Dec 2022

Sharp increase in B cell population can prevent intestinal healing

B cells are critical to the proper functioning of the immune system. However, researchers at Karolinska Institutet have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel damage, preventing the tissue from healing.

2 Dec 2022