Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

New insight into mechanism regulating early mammalian development

Scientists at the Genome Institute of Singapore (GIS) have recently generated significant single cell expression data crucial for a detailed molecular understanding of mammalian development from fertilization to embryo implantation, a process known as the preimplantation period. The knowledge gained has a direct impact on clinical applications in the areas of regenerative medicine and assisted reproduction.

22 Apr 2010

Positive results from preclinical EP-302 program presented at AACR 2010

Drug discovery and development company Esperance Pharmaceuticals today presented positive results from their preclinical EP-302 program that support the initiation of IND enabling studies. EP-302 is a targeted membrane-disrupting peptide designed to selectively kill cells that express nucleolin on their surface. Nucleolin is a protein that is over-expressed in a wide range of cancers and tumor endothelial cells.

22 Apr 2010

AVEO Pharmaceuticals presents data on potential utility of Notch1-specific monoclonal antibody at 101st AACR

AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused on discovering, developing and commercializing cancer therapeutics, today announced preclinical data which demonstrate that its Notch1-specific monoclonal antibody is a highly potent inhibitor of Notch1 function in both in vitro and in vivo models. These data were presented today at the American Association for Cancer Research (AACR) 101st Annual Meeting 2010 in Washington, D.C.

22 Apr 2010

Researchers develop new mouse model of VUR to study chronic kidney disease in children

Kidney damage associated with chronic reflux is the fourth leading cause of chronic kidney disease and is the most common cause of severe hypertension in children. Doctors and researchers at Nationwide Children's Hospital have developed a new mouse model of vesicoureteral reflux, a common childhood condition that can lead to chronic kidney disease in children.

7 Apr 2010

ARQ 197 demonstrates 66% improvement in median PFS in patients with advanced NSCLC

ArQule, Inc. today announced that ARQ 197, when used in combination with erlotinib, demonstrated a 66% improvement in median Progression-Free Survival in patients with advanced, refractory non-small cell lung cancer.

31 Mar 2010

Two separate articles describing preclinical data of ACE-041 published

Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone, muscle, fat, and the vasculature, announced the publication of two separate peer-reviewed articles describing preclinical data demonstrating that treatment with ACE-041, an inhibitor of signaling through the activin receptor-like kinase 1 receptor, slows tumor growth and progression by inhibiting angiogenesis.

26 Mar 2010

MIT biochemist joins Thomson Reuters’ annual ‘Top 12’ list

The world's "hottest" researcher is biochemist Rudolf Jaenisch from the Massachusetts Institute of Technology. He is joined by scientists scattered from Ann Arbor to Osaka on the annual Thomson Reuters list of the world's 12 hottest researchers.

16 Mar 2010

Patient enrollment in Phase II study of BioCart Autologous Cartilage System nearing halfway point

ProChon Biotech, Ltd., an innovator of tissue regenerative technologies that are being developed to relieve pain and restore the mobility and quality-of-life for sufferers of articular cartilage injuries, today announced that patient enrollment in the Company’s Phase II study of the BioCart™ Autologous Cartilage System is nearing the halfway point and is expected to be completed within the next three months.

5 Mar 2010

Exposure to blue-violet light may enhance cell growth in wound sites

Today, during the 39th Annual Meeting of the American Association for Dental Research, convening at the Walter E. Washington Convention Center in Washington, DC, lead researcher C. Millan (U.S. Army Dental Corps, Martinez, Georgia) will present a poster of a study titled "A Novel In Vitro Model for Light-Induced Wound Healing."

4 Mar 2010

Blood glucose-lowering hormone FGF21 also activates brown adipose tissue metabolism

The blood glucose-lowering hormone FGF21 is also an activator of brown adipose tissue metabolism, according to the study featured on the cover of Cell Metabolism and directed by the lecturer Francesc Villarroya of the UB's Department of Biochemistry and Molecular Biology (Faculty of Biology), the Institute of Biomedicine, and the Biomedical Research Networking Centre in Physiopathology of Obesity and Nutrition.

3 Mar 2010

ArQule reports net loss of $36,136,000 for 2009

ArQule, Inc. today announced its financial results for the year and for the fourth quarter ended December 31, 2009.

2 Mar 2010

New project to unravel secret lives of cancer cells may help produce new cancer therapies

A team of scientists from Princeton University and The Cancer Institute of New Jersey has embarked on a major new project to unravel the secret lives of cancer cells that go dormant and self-cannibalize to survive periods of stress. The work may help produce new cancer therapies to stem changes that render cancer cells dangerous and resistant to treatment.

12 Feb 2010

Research suggests growth factor gene plays a central role in palate development

Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal.

3 Feb 2010

The American Journal of Pathology: Highlights from February 2010 issue

A group led by Dr. Peter Lloyd Jones at the University of Dundee, Dundee, Scotland; the University of Colorado Denver, Aurora, CO; and the University of Pennsylvania, Philadelphia, PA has demonstrated that tenascin-C affects proto-oncogene function in breast cancer. Their report can be found in the February 2010 issue of The American Journal of Pathology.

22 Jan 2010

Scientists study fruit fly to identify key molecular signal in cancer metastasis

Scientists trying to understand how cancer cells invade healthy tissue have used the fruit fly's metamorphosis from maggot to flying insect as a guide to identify a key molecular signal that may be involved in both processes.

20 Jan 2010

Scientists and clinicians address diagnosis and treatment for autoimmune and autoinflammatory diseases

Autoimmune and autoinflammatory diseases are a major health issue. The National Institutes of Health reports that up to 23.5 million Americans are afflicted. The American Autoimmune Related Diseases Association reports the number is closer to 50 million. Scientists and clinicians at The University of Texas Health Science Center at Houston can address the diagnosis and treatment of these conditions, as well as the latest advances in research.

8 Jan 2010

ProChon Biotech announces expansion of BioCart Cartilage Regeneration System study

ProChon Biotech, Ltd., an innovator of tissue regenerative technologies that are being developed to relieve pain and restore the mobility and quality of life for sufferers of articular cartilage injuries, today announced a significant expansion of its clinical study of the BioCart™ Cartilage Regeneration System.

15 Dec 2009

Cell transplants may yield new therapies for dementia patients

Nerve cells transplanted into brain-damaged rats helped them to fully recover their ability to learn and remember, probably by promoting nurturing, protective growth factors, according to a new study.

10 Dec 2009

Novel multi-analyte approach to develop urine-biomarker based diagnostic assay to be presented

Predictive Biosciences today announced that Company scientists will be presenting a novel multi-analyte approach to the development of a non-invasive, urine-biomarker based diagnostic assay during the 10th Annual Meeting of the Society of Urologic Oncology (SUO).

3 Dec 2009

Vitro Diagnostics files a patent application for its technology related to generation of iPS cells

Vitro Diagnostics, Inc., dba Vitro Biopharma, announced the filing of a new United States patent application entitled “POU5-F1 Expression in Human Mesenchymal Stem Cells” and the development of new technology related to generation of human induced pluripotent stem cells (iPS).

2 Dec 2009

Fibroblast News and Research

Further Reading

New insight into mechanism regulating early mammalian development

Positive results from preclinical EP-302 program presented at AACR 2010

AVEO Pharmaceuticals presents data on potential utility of Notch1-specific monoclonal antibody at 101st AACR

Researchers develop new mouse model of VUR to study chronic kidney disease in children

ARQ 197 demonstrates 66% improvement in median PFS in patients with advanced NSCLC

Two separate articles describing preclinical data of ACE-041 published

MIT biochemist joins Thomson Reuters’ annual ‘Top 12’ list

Patient enrollment in Phase II study of BioCart Autologous Cartilage System nearing halfway point

Exposure to blue-violet light may enhance cell growth in wound sites

Blood glucose-lowering hormone FGF21 also activates brown adipose tissue metabolism

ArQule reports net loss of $36,136,000 for 2009

New project to unravel secret lives of cancer cells may help produce new cancer therapies

Research suggests growth factor gene plays a central role in palate development

The American Journal of Pathology: Highlights from February 2010 issue

Scientists study fruit fly to identify key molecular signal in cancer metastasis

Scientists and clinicians address diagnosis and treatment for autoimmune and autoinflammatory diseases

ProChon Biotech announces expansion of BioCart Cartilage Regeneration System study

Cell transplants may yield new therapies for dementia patients

Novel multi-analyte approach to develop urine-biomarker based diagnostic assay to be presented

Vitro Diagnostics files a patent application for its technology related to generation of iPS cells

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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