Structural Biology News and Research

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Scientists study key malaria protein structure to demonstrate how cells grow and move

Researchers from the Walter and Eliza Hall Institute have overturned conventional wisdom on how cell movement across all species is controlled, solving the structure of a protein that cuts power to the cell 'motor'. The protein could be a potential drug target for future malaria and anti-cancer treatments.

31 May 2011

GIS discovery could help generate stem cells more efficiently for biomedical applications

A team of scientists from Genome Institute of Singapore (GIS) of the Agency for Science, Technology and Research (A*STAR) have shown how proteins involved in controlling genes work together to carry out their functions in stem cells and demonstrated for the very first time, how they can change interaction partners to make other types of cells.

20 May 2011

Study offers new understanding of cell signaling networks tied to diabetes and cancer

Researchers at the University of Texas Medical Branch at Galveston and the University of California-San Diego School of Medicine have published a study that offers a new understanding of a protein critical to physiological processes involved in major diseases such as diabetes and cancer. This work could help scientists design drugs to battle these disorders.

18 May 2011

New method helps scientists to determine specific protein molecular structure

The structures of many protein molecules remain unsolved even after experts apply an extensive array of approaches. An international collaboration has led to a new, high-performance method that rapidly determined the structure of protein molecules in several cases where previous methods had failed.

2 May 2011

Scientists develop new compound for multiple sclerosis treatment

Scientists from the Florida campus of The Scripps Research Institute have developed the first of a new class of highly selective compounds that effectively suppresses the severity of multiple sclerosis in animal models.

18 Apr 2011

Bruker offers new TopSpin NMR software to MAC users

At the 52nd ENC, Bruker is welcoming Apple users to its industry-leading TopSpin™ NMR software. Mac OS X joins Windows and Linux as supported operating systems for Bruker's TopSpin processing software, providing NMR scientists in academia and industry with the ability to use the operating environment of their choice.

11 Apr 2011

Takeda, Heptares collaborate to develop new drugs against CNS disorders

Heptares Therapeutics and Takeda Pharmaceutical Company today announced the formation of a two-year drug discovery collaboration focused on a single G-protein coupled receptor that plays an important role in the pathology of central nervous system disorders.

11 Apr 2011

ASBMB honors Stanford professor with DeLano Award for Computational Biosciences

Stanford University professor Axel T. Brunger has been named the winner of the American Society for Biochemistry and Molecular Biology's inaugural DeLano Award for Computational Biosciences. Brunger will present his award lecture, titled "Towards Structural Biology with Single Molecules" at 9:03 a.m. on Wednesday, April 13, at the Experimental Biology 2011 conference at the Walter E. Washington Convention Center in Washington, D.C.

8 Apr 2011

ASBMB to honor 11 scientists with annual awards for biomedical research

The winners of the American Society for Biochemistry and Molecular Biology annual awards will give lectures at the Experimental Biology 2011 conference April 9-13 at the Walter E. Washington Convention Center in Washington, D.C.

8 Apr 2011

Scientists identify two molecules that enable cancer spread

For many types of cancer, the original tumor itself is usually not deadly. Instead, it's the spread of a tiny subpopulation of cells from the primary tumor to other parts of the body—the process known as metastasis—that all too often kills the patient.

8 Apr 2011

Research offers first structural insights into 'client' protein shape in chaperone presence

In the constantly morphing field of protein structure, scientists at The Scripps Research Institute offer yet another surprise: a common "chaperone" protein in cells thought to help other proteins fold has been shown instead to loosen them.

4 Apr 2011

New discovery provides insight into complex Rad50 molecular motor function

Over the last years, two teams of researchers at The Scripps Research Institute have steadily built a model of how a powerful DNA repair complex works. Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions - findings they say may have implications for treatment of disorders ranging from cancer to cystic fibrosis.

28 Mar 2011

NeoProteomics secures exclusive option agreement with Case Western Reserve University

NeoProteomics Inc., a biomarker development and software company, has secured an exclusive option agreement with Case Western Reserve University. The deal has potential to enhance various forms of treatment of cancer, diabetes, and inflammatory diseases.

28 Mar 2011

Biologists decipher molecular code regulating availability of brain channel linked to neuronal excitability

A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where interactions governing channel protein activity can alter an organism's behavior.

23 Mar 2011

Vitamin A may play key role in sperm cell formation and development of central nervous system

In a recently-published study mapping the structure and function of the so-called "orphan" nuclear receptor TR4, Van Andel Research Institute (VARI) investigators suggest that Vitamin A may play a more direct role than was previously known in certain physiological functions including sperm cell formation and the development of the central nervous system.

18 Mar 2011

Researchers discover 3-D structure of key biological receptor

Researchers have solved the three-dimensional structure of a key biological receptor. The finding has the potential to speed drug discovery in many areas, from arthritis to respiratory disorders to wound healing, because it enables chemists to better examine and design molecules for use in experimental drugs.

16 Mar 2011

Study identifies potential therapeutic target for neurodegenerative disorders

Cell biologists pondering the death of neurons - brain cells - said today that by eliminating one ingredient from the cellular machinery, they prolonged the life of neurons stressed by a pesticide chemical. The finding identifies a potential therapeutic target to slow changes that lead to neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

14 Mar 2011

Scientists complete protein 3D structural sequence essential for cellular function

Researchers at IRB Barcelona have completed the 3D structural sequence adopted by several essential proteins in the exchange of substances between the extra and intracellular milieu. This finding provides a global perspective of the structural changes that occur in these relevant proteins during basic cell processes, such as protein synthesis, the regulation of metabolism and cell volume, and nerve transmission.

24 Feb 2011

Researchers develop hard X-ray laser to determine structure of biomolecules

Unraveling the molecular basis of life is an age-old quest of humanity. A breakthrough towards this goal was reported in a pair of studies published Feb. 3 in the scientific journal Nature, detailing a new method developed to determine structures of biomolecules based on diffraction from protein nanocrystals that are so small that they are not even visible under the microscope.

3 Feb 2011

Scientists to develop enzyme that protects against nerve agents

Protection against nerve gas attack is a significant component of the defense system of many countries around the world. Nerve gases are used by armies and terrorist organizations, and constitute a threat to both the military and civilian populations, but existing drug solutions against them have limited efficiency.

25 Jan 2011

Structural Biology News and Research

Scientists study key malaria protein structure to demonstrate how cells grow and move

GIS discovery could help generate stem cells more efficiently for biomedical applications

Study offers new understanding of cell signaling networks tied to diabetes and cancer

New method helps scientists to determine specific protein molecular structure

Scientists develop new compound for multiple sclerosis treatment

Bruker offers new TopSpin NMR software to MAC users

Takeda, Heptares collaborate to develop new drugs against CNS disorders

ASBMB honors Stanford professor with DeLano Award for Computational Biosciences

ASBMB to honor 11 scientists with annual awards for biomedical research

Scientists identify two molecules that enable cancer spread

Research offers first structural insights into 'client' protein shape in chaperone presence

New discovery provides insight into complex Rad50 molecular motor function

NeoProteomics secures exclusive option agreement with Case Western Reserve University

Biologists decipher molecular code regulating availability of brain channel linked to neuronal excitability

Vitamin A may play key role in sperm cell formation and development of central nervous system

Researchers discover 3-D structure of key biological receptor

Study identifies potential therapeutic target for neurodegenerative disorders

Scientists complete protein 3D structural sequence essential for cellular function

Researchers develop hard X-ray laser to determine structure of biomolecules

Scientists to develop enzyme that protects against nerve agents

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