Enzyme News and Research

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Reptile food causes allergic reactions

Reptiles are often chosen as pets when an allergy risk exists within a family and the choice is made to avoid potentially allergenic pets such as dogs, cats or guinea pigs.

30 Oct 2015

Novel enzyme therapy offers possible treatment for cocaine overdose

A long-acting enzyme that rapidly and safely metabolizes cocaine in the blood stream is currently being investigated in animal models as a possible treatment for cocaine overdose.

30 Oct 2015

Halozyme Therapeutics announces initiation of rivipansel Phase 1 clinical trial

Halozyme Therapeutics, Inc. today announced that the first healthy subject has been dosed in a Phase 1 clinical trial evaluating the safety, tolerability and pharmacokinetics of a subcutaneous formulation of rivipansel, a compound discovered by GlycoMimetics, Inc. and being developed by Pfizer Inc., using Halozyme's ENHANZE formulation.

30 Oct 2015

Certain drugs could be used to treat gastric cancers with particular pattern of mutations

Gastric cancer, otherwise known as stomach cancer, does not respond well to existing treatments and it is currently the third leading cause of cancer death in the world (after lung and liver cancer). Researchers have discovered that certain drugs, currently used to treat breast, ovarian and pancreatic cancers, could also be used to treat certain gastric cancers with a particular pattern of mutations (genomic molecular fingerprint).

29 Oct 2015

UAB researcher awarded NIH grant to study pathogenesis of thrombotic microangiopathy

University of Alabama at Birmingham researcher X. Long Zheng, M.D., Ph.D., has received a five-year, $2.5 million National Institutes of Health grant to study the pathogenesis of thrombotic microangiopathy, or TMA. In simple terms, this means looking for factors that cause or aid the onset of extensive microscopic clots in small blood vessels throughout the body. Though tiny, these spots can damage kidneys, heart and brain, and they can cause death.

29 Oct 2015

Study demonstrates efficacy of everolimus in treating nonfunctional neuroendocrine tumours of the lung

The results of the international, multicenter, Phase 3 RADIANT-4 study clearly demonstrate the efficacy of the agent everolimus in treating nonfunctional neuroendocrine tumours of lung or gastrointestinal origin.

28 Oct 2015

Researchers identify role of cGAS enzyme in autoimmune diseases

Activating an enzyme that sounds an alarm for the body's innate immune system causes two lethal autoimmune diseases in mice, while inhibiting the same enzyme rescues them, UT Southwestern Medical Center researchers report.

28 Oct 2015

WSU collaborates with Botanisol to study and develop new anti-inflammatory drug

Work on a new anti-inflammatory drug developed from the medicinal/spice plant turmeric recently received funding from a $225,000 grant from the National Institutes of Health National Center for Complementary and Integrative Health.

28 Oct 2015

Oral formulation of insulin shows promise in management of blood glucose in diabetic rats

An intestinal patch device containing insulin that can be swallowed in the form of a capsule, in development by researchers at University of California Santa Barbara, has demonstrated efficacy of blood glucose management in diabetic rats. This work is being presented Oct. 27 at the 2015 American Association of Pharmaceutical Scientists Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Orlando, Fla. Oct. 25-29.

28 Oct 2015

Nanofiber hydrogel infused with snake venom may stop bleeding, protect wounds

A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists.

27 Oct 2015

Scientists find way to produce industrial quantities of beneficial natural compounds in tomatoes

Scientists at the John Innes Centre have found a way to produce industrial quantities of useful natural compounds efficiently, by growing them in tomatoes.

26 Oct 2015

Inhibiting JAK family of enzymes promotes rapid hair growth, new study finds

Inhibiting a family of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study from researchers at Columbia University Medical Center has found.

26 Oct 2015

FDA approves Yondelis (trabectedin) for treatment of specific soft tissue sarcomas

The U.S. Food and Drug Administration today approved Yondelis (trabectedin), a chemotherapy, for the treatment of specific soft tissue sarcomas (STS) – liposarcoma and leiomyosarcoma – that cannot be removed by surgery (unresectable) or is advanced (metastatic).

24 Oct 2015

Strensiq approved for treatment of patients with juvenile-onset HPP

Today, the U.S. Food and Drug Administration approved Strensiq (asfotase alfa) as the first approved treatment for perinatal, infantile and juvenile-onset hypophosphatasia (HPP).

24 Oct 2015

Alaska pollock gelatin can be used to treat pulmonary diseases

In recent years, patients with pulmonary emphysema have been increasing mainly among middle-aged and elderly males due to aging and excessive smoking. Emphysema makes brittle lungs, and in severe cases, holes develop in the lung tissue, causing air leakage. Researchers at NIMS developed a new sealant to close holes developed in lungs and blood vessels using Alaska pollock gelatin.

23 Oct 2015

Potential new drug target for acute myeloid leukemia

New treatment options are badly needed for acute myeloid leukemia, a relatively rare form of cancer. The malignancy begins in the bone marrow, and from there can spread rapidly to the bloodstream, depriving the body of the essential blood cells that carry oxygen and fight infections.

23 Oct 2015

Research shows deep-sea bacteria could help neutralize atmospheric greenhouse gases

A type of bacteria plucked from the bottom of the ocean could be put to work neutralizing large amounts of industrial carbon dioxide in the Earth's atmosphere, a group of University of Florida researchers has found.

23 Oct 2015

DNA study reveals basic principle of gene regulation

A study of where and how an enzyme cuts DNA may have inadvertently revealed a basic principle of gene regulation, say researchers in Boston Children's Hospital's Program in Cellular and Molecular Medicine (PCMM).

23 Oct 2015

Scientists identify gene that could lead to development of new treatments for sepsis

Scientists have identified a gene that could potentially open the door for the development of new treatments of the lethal disease sepsis.

22 Oct 2015

Study reveals poor levels of use, availability and affordability of cardiovascular disease medicines worldwide

New research published in The Lancet shows that the use of vital life-saving generic (and supposedly inexpensive) medicines for prevention in people with existing heart disease is poor worldwide. In low-income and middle-income countries these medicines are not widely available and, when available, can often be unaffordable. In rich countries, although such medicines are both available and affordable, 35% to 50% of patients who have heart disease or a previous stroke still do not receive them.

22 Oct 2015

Enzyme News and Research

Reptile food causes allergic reactions

Novel enzyme therapy offers possible treatment for cocaine overdose

Halozyme Therapeutics announces initiation of rivipansel Phase 1 clinical trial

Certain drugs could be used to treat gastric cancers with particular pattern of mutations

UAB researcher awarded NIH grant to study pathogenesis of thrombotic microangiopathy

Study demonstrates efficacy of everolimus in treating nonfunctional neuroendocrine tumours of the lung

Researchers identify role of cGAS enzyme in autoimmune diseases

WSU collaborates with Botanisol to study and develop new anti-inflammatory drug

Oral formulation of insulin shows promise in management of blood glucose in diabetic rats

Nanofiber hydrogel infused with snake venom may stop bleeding, protect wounds

Scientists find way to produce industrial quantities of beneficial natural compounds in tomatoes

Inhibiting JAK family of enzymes promotes rapid hair growth, new study finds

FDA approves Yondelis (trabectedin) for treatment of specific soft tissue sarcomas

Strensiq approved for treatment of patients with juvenile-onset HPP

Alaska pollock gelatin can be used to treat pulmonary diseases

Potential new drug target for acute myeloid leukemia

Research shows deep-sea bacteria could help neutralize atmospheric greenhouse gases

DNA study reveals basic principle of gene regulation

Scientists identify gene that could lead to development of new treatments for sepsis

Study reveals poor levels of use, availability and affordability of cardiovascular disease medicines worldwide

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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