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Activating bacterial receptors boosts macrophage response, limits damage to spinal cord following injury

Macrophages are cellular sentinels in the body, assigned to identify "attacks" from viruses, bacteria, or fungi and sound the alarm when they are present. However, these cells are a "double edged sword" in spinal cord injury, providing both neural repair-promoting properties and pathological functions that destroy neuronal tissue

13 Jul 2015

Connexient, RWJUH announce public launch of MediNav Navigator Edition 2.0

Connexient and Robert Wood Johnson University Hospital announced this week the public launch of MediNav Navigator Edition 2.0. This makes RWJUH the first hospital in North America to deliver for its patients, visitors and staff the world's first true turn-by-turn indoor navigation smartphone application, with reliable indoor positioning accuracy of one to two meters.

10 Jul 2015

Potential molecular link identified between excess fat in the blood and blood vessel recovery in ischemia

The buildup of fat in the blood makes a bad situation worse - it not only raises a person's risk for heart attack or stroke but also impairs the growth of new blood vessels. How excess fat in the blood - a condition known as hyperlipidemia - blocks vessel growth was unclear, but new work by researchers at Temple University School of Medicine shows that a molecule known as caspase-1 plays a central role and that preventing its activity could be the key to building new blood vessels and restoring blood supply to oxygen-starved tissues.

10 Jul 2015

Retrosplenial cortex serves as 'conjunction junction' for brain's navigation function

Ever wake at night needing a drink of water and then find your way to the kitchen in the dark without stubbing your toe?

10 Jul 2015

Tillotts Pharma to purchase global rights for AstraZeneca’s Entocort excluding the U.S.

Tillotts Pharma AG, part of the Zeria Group, announced today that it has entered into an agreement for the acquisition of the global rights for Entocort (budesonide) from AstraZeneca, excluding the U.S., which will remain with AstraZeneca.

9 Jul 2015

New UCLA study reveals genetic architecture of schizophrenia

A new study by UCLA scientists adds to the understanding of the genetic architecture of schizophrenia. Past research has shown the impact of commonly occurring genetic variants on a person's risk of developing schizophrenia. This new study focused instead on rare coding mutations that affect protein function. It found that patients with schizophrenia have a higher-than-normal share of these mutations.

9 Jul 2015

Janssen-sponsored Phase 2b trial shows guselkumab effective in treating moderate to severe plaque psoriasis

Results published today in The New England Journal of Medicine from a Janssen Research & Development, LLC (Janssen)-sponsored Phase 2b trial showed up to 86 percent of patients with moderate to severe plaque psoriasis receiving guselkumab (CNTO 1959) achieved a Physician's Global Assessment (PGA) score of cleared psoriasis or minimal psoriasis at week 16, the study's primary endpoint.

9 Jul 2015

EvoRx Technologies, AstraZeneca successfully complete research collaboration

AstraZeneca and EvoRx Technologies successfully completed a one-year research collaboration leveraging EvoRx's proprietary Evo-Link technology to discover cell penetrating peptides for a high value intracellular protein–protein interaction target in the respiratory portfolio.

9 Jul 2015

Johns Hopkins, IOCB Prague sign drug discovery research agreement

The Johns Hopkins Drug Discovery (JHDD) program, created with the mission of identifying novel drug targets arising from Johns Hopkins faculty research and translating them into new therapeutics, and the Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences (IOCB Prague) have entered into a five-year drug discovery research agreement to develop small-molecule and peptide drugs for a range of therapeutic areas including neurological diseases, cancer and gastrointestinal disorders.

9 Jul 2015

Researchers find way to measure the aging process in young adults

An international research team from the US, UK, Israel and New Zealand has found a way to measure the aging process in young adults -- a younger population than is usually tested in aging studies.

9 Jul 2015

Diabetes and high blood sugar impose negative effect on cognitive, decision-making skills

MINNEAPOLIS - In just two years, people with type 2 diabetes experienced negative changes in their ability to regulate blood flow in the brain, which was associated with lower scores on tests of cognition skills and their ability to perform their daily activities, according to a new study published in the July 8, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

9 Jul 2015

Research examines reasons behind variation in prescription practices of antidepressants across Europe

Public attitudes towards mental illness and levels of healthcare spending may explain the huge variation in antidepressant use across Europe, according to a new study by researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London.

9 Jul 2015

Study: Brain activity changes after memory retraining in TBI patients

Kessler Foundation researchers published results of their TBI-MEM trial, the first study to demonstrate significant changes in cerebral activation after memory retraining in individuals with traumatic brain injury.

9 Jul 2015

Decreased connectivity between network-specific brain regions linked to cognitive deficit in MS

An estimated 2.3 million individuals are living with multiple sclerosis (MS) worldwide. Approximately half of all individuals with MS experience changes in cognition such as impaired concentration, attention, memory, and judgment. The underlying brain basis for these deleterious effects has been largely elusive.

8 Jul 2015

Researchers develop novel technique to generate activated T cells to tackle advanced melanoma

T cells from patients with melanoma can trigger a protective immune response against the disease according to a new study out of University Hospitals Case Medical Center Seidman Cancer Center and Case Western Reserve University School of Medicine.

8 Jul 2015

Georgia State University-led study identifies structural brain abnormalities in schizophrenia patients

Structural brain abnormalities in patients with schizophrenia, providing insight into how the condition may develop and respond to treatment, have been identified in an internationally collaborative study led by a Georgia State University scientist.

7 Jul 2015

EnteroMedics prices previously announced public offering of 32,000,000 units

EnteroMedics Inc., a developer and manufacturer of devices that use neuroblocking technology to treat obesity, metabolic diseases, and other gastrointestinal disorders, announced the pricing of its previously announced public offering of 32,000,000 units.

7 Jul 2015

Scientists and families to gather in The Woodlands, Texas to build up community around Christianson Syndrome

It takes a committed community to develop effective treatments for a new disease. With that hope, scientists and families will come together in a Houston suburb July 30- Aug. 2 to build up the community around Christianson Syndrome, a genetic intellectual disability disorder, often associated with autistic features, first discovered 16 years ago.

7 Jul 2015

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Peripheral nerve injuries often are caused by trauma or surgical complications and can result in considerable disabilities. Regeneration of peripheral nerves can be accomplished effectively using autologous (self-donated) nerve grafts, but that procedure may sacrifice a functional nerve and cause loss of sensation in another part of the patient's body.

7 Jul 2015

Sialic acid attached to brain cells may affect brain structure, cause neurological problems

New research from The Johns Hopkins University suggests that a molecule commonly found “decorating” brain cells in higher animals, including humans, may affect brain structure.

7 Jul 2015

Neuroscience News and Research

Activating bacterial receptors boosts macrophage response, limits damage to spinal cord following injury

Connexient, RWJUH announce public launch of MediNav Navigator Edition 2.0

Potential molecular link identified between excess fat in the blood and blood vessel recovery in ischemia

Retrosplenial cortex serves as 'conjunction junction' for brain's navigation function

Tillotts Pharma to purchase global rights for AstraZeneca’s Entocort excluding the U.S.

New UCLA study reveals genetic architecture of schizophrenia

Janssen-sponsored Phase 2b trial shows guselkumab effective in treating moderate to severe plaque psoriasis

EvoRx Technologies, AstraZeneca successfully complete research collaboration

Johns Hopkins, IOCB Prague sign drug discovery research agreement

Researchers find way to measure the aging process in young adults

Diabetes and high blood sugar impose negative effect on cognitive, decision-making skills

Research examines reasons behind variation in prescription practices of antidepressants across Europe

Study: Brain activity changes after memory retraining in TBI patients

Decreased connectivity between network-specific brain regions linked to cognitive deficit in MS

Researchers develop novel technique to generate activated T cells to tackle advanced melanoma

Georgia State University-led study identifies structural brain abnormalities in schizophrenia patients

EnteroMedics prices previously announced public offering of 32,000,000 units

Scientists and families to gather in The Woodlands, Texas to build up community around Christianson Syndrome

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Sialic acid attached to brain cells may affect brain structure, cause neurological problems

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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