Bone News and Research

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SDF-1 turns on autophagy that helps cells stay in place and focused on making bone

A signaling molecule that helps stem cells survive in the naturally low-oxygen environment inside the bone marrow may hold clues to helping the cells survive when the going gets worse with age and disease, researchers report.

11 Mar 2013

Scientists develop new method for replacing missing teeth

Scientists have developed a new method of replacing missing teeth with a bioengineered material generated from a person's own gum cells.

11 Mar 2013

Weight loss may help prevent and alleviate symptoms of osteoarthritis

Weight loss may prevent and significantly alleviate the symptoms of osteoarthritis, a progressive disease of the joints known as "wear and tear" arthritis, according to a literature review appearing in the March 2013 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS).

11 Mar 2013

Cell fusion studies at Johns Hopkins could lead to improved treatments for muscular dystrophy

Researchers at Johns Hopkins have established a high-efficiency cell-cell fusion system, providing a new model to study how fusion works. The scientists showed that fusion between two cells is not equal and mutual as some assumed, but, rather, is initiated and driven by one of the fusion partners. The discovery, they say, could lead to improved treatments for muscular dystrophy, since muscle regeneration relies on cell fusion to make muscle fibers that contain hundreds or even thousands of nuclei.

8 Mar 2013

Femoral canal change detected in women over time

Women experience a gradual expansion in femoral canal diameter with increasing age, which could impact the longevity of total hip replacement, UK researchers report. age, which could impact the longevity of total hip replacement, UK researchers report.

8 Mar 2013

Researchers uncover cellular-level detail of what happens when bone bears stress over time

From athletes to individuals suffering from osteoporosis, bone fractures are usually the result of tiny cracks accumulating over time -- invisible rivulets of damage that, when coalesced, lead to that painful break.

8 Mar 2013

Acceleron commences ACE-536 phase 2 study in beta-thalassemia

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, today announced the initiation of a phase 2 study of its novel, investigational protein therapeutic, ACE-536, to treat patients with beta-thalassemia, a genetic hematologic disorder causing chronic and life-threatening anemia and serious complications affecting the spleen, liver and heart.

7 Mar 2013

USF, Saneron receive patent for transplantation method using umbilical cord blood cells

Researchers at Saneron CCEL Therapeutics and the University of South Florida have received a patent relating to a method for obtaining and using umbilical cord blood cells from a donor or patient to provide neural cells for transplantation aimed at repairing a variety of neurodegenerative diseases of the brain and spinal cord, such as Parkinson's disease, Huntington's disease, multiple sclerosis, Alzheimer's disease as well as brain and spinal cord injury.

7 Mar 2013

Study investigates how cancer cells 'hijack' platelets

A new research study has investigated how cancer cells 'hijack' blood cells known as platelets, enabling cancer to spread around the body and promoting the growth of new tumours, it was reported today at the annual Royal College of Surgeons in Ireland (RCSI) Research Day.

7 Mar 2013

Chemotherapy-free stem cell transplant shows promise for sickle cell disease

Two brothers have been cured of their sickle cell disease at the University of Illinois Hospital & Health Sciences System using a relatively uncommon type of stem cell transplant that is performed without chemotherapy.

6 Mar 2013

Media examine reaction to, potential implications of 'functional cure' of infant born with HIV

"The remarkable case of a baby being cured of HIV infection in the United States using readily available drugs has raised new hope for eradicating the infection in infants worldwide, but scientists say it will take a lot more research and much more sensitive diagnostics before this hope becomes a reality," Reuters reports.

6 Mar 2013

Inventors from 3 leading universities receive $30,000 Lemelson-MIT Student Prize

Nikolai Begg grew up in a box of LEGO- bricks and hasn't stopped tinkering since. Today he is an accomplished inventor with a portfolio of novel medical devices. Begg is the recipient of the prestigious $30,000 Lemelson-MIT Student Prize for his inventions that are making surgical procedures less invasive.

6 Mar 2013

Two novel radiolabeled small molecules can help detect prostate cancer

Two novel radiolabeled small molecules targeting prostate-specific membrane antigen (PSMA) have excellent potential for further development as diagnostic and therapeutic radiopharmaceuticals, according to research published this month in The Journal of Nuclear Medicine.

6 Mar 2013

AAP, ACMG release guidelines on best practices for genetic testing and screening of children

For the first time, the American Academy of Pediatrics (AAP) and the American College of Medical Genetics and Genomics (ACMG) spoke with one voice and released a set of recommendations and guidelines on best practices for genetic testing and screening of children.

5 Mar 2013

OPKO Health acquires Cytochroma

OPKO Health, Inc. announced that it has completed the acquisition of Cytochroma Inc. Cytochroma's lead products include CTAP101 Capsules, a vitamin D prohormone to treat secondary hyperparathyroidism (SHPT) in patients with stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency, and Fermagate Tablets, a new and potent non-absorbed phosphate binder to treat hyperphosphatemia in CKD patients on chronic hemodialysis.

4 Mar 2013

Researchers discover new candidate disease proteins for neurodegenerative disorders

A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders.

4 Mar 2013

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad.

4 Mar 2013

Bone News and Research

SDF-1 turns on autophagy that helps cells stay in place and focused on making bone

Scientists develop new method for replacing missing teeth

Weight loss may help prevent and alleviate symptoms of osteoarthritis

Cell fusion studies at Johns Hopkins could lead to improved treatments for muscular dystrophy

Femoral canal change detected in women over time

Researchers uncover cellular-level detail of what happens when bone bears stress over time

Acceleron commences ACE-536 phase 2 study in beta-thalassemia

USF, Saneron receive patent for transplantation method using umbilical cord blood cells

Study investigates how cancer cells 'hijack' platelets

Chemotherapy-free stem cell transplant shows promise for sickle cell disease

Media examine reaction to, potential implications of 'functional cure' of infant born with HIV

Inventors from 3 leading universities receive $30,000 Lemelson-MIT Student Prize

Two novel radiolabeled small molecules can help detect prostate cancer

AAP, ACMG release guidelines on best practices for genetic testing and screening of children

OPKO Health acquires Cytochroma

Researchers discover new candidate disease proteins for neurodegenerative disorders

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

Chroma Therapeutics, CTI announce results from tosedostat Phase 2 study on AML

Older patients with head and neck cancers less likely to die in high-volume hospitals

Study identifies how new ALS gene mutations cause other diseases of the brain, muscle and bone

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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