Blood Vessels News and Research

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Sildenafil improves blood flow after heart attack in an animal model

Dogs treated with sildenafil, a drug most commonly used to treat erectile dysfunction, had better blood flow in coronary arteries than control animals, following an induced artery obstruction and treatment that modeled a heart attack and standard medical care given to people

13 Apr 2006

Losartan can prevent progression of Marfan syndrome

A commonly prescribed blood pressure medication may provide the first ray of hope in preventing potentially deadly complications of Marfan syndrome, a genetic disease that weakens the structural meshwork of blood vessels.

11 Apr 2006

Fat cells surrounding coronary arteries may play a role in development of heart disease

The fat cells that surround coronary arteries may play a central and previously unrecognized role in development of cardiovascular disease, according to a study by University of Iowa researchers.

11 Apr 2006

Scientists use corrective gene to block a protein in the kidneys that triggers high blood pressure

Nearly one-third of American adults have high blood pressure, a major cause of heart attacks, strokes and kidney failure. But a new technique tested at the University of Florida could prove to be a long-term way to treat the disorder in humans, researchers say.

11 Apr 2006

Carbon monoxide inhibitor controls traumatic bleeding

A chemical that blocks carbon monoxide (CO) has been used for the first time to arrest traumatic bleeding in rats, according to a Tulane University research team.

6 Apr 2006

Custom-made bladders produced from patients' own cells

Scientists in the U.S. have produced custom-made bladders grown from patients' own cells which have been have been successfully transplanted and function well.

4 Apr 2006

First human recipients of laboratory-grown organs

The first human recipients of laboratory-grown organs were by Anthony Atala, M.D., director of the Institute for Regenerative Medicine at Wake Forest University School of Medicine. In The Lancet, Atala describes long-term success in children and teenagers who received bladders grown from their own cells.

4 Apr 2006

Regular use of COX-2 inhibitors may reduce the risk of breast cancer

Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers.

4 Apr 2006

Moderate alcohol intake stimulates tumor angiogenesis and expression of vascular endothelial growth factor in a mouse model

University of Mississippi researchers say they have created the first-ever mammalian model of how alcohol consumption spurs tumor growth, showing that even moderate drinking resulted in larger and more robust tumors.

4 Apr 2006

Robotic device appears to be more precise than conventional catheter ablation devices for atrial fibrillation

A remotely-controlled catheter device guided by magnetic fields provides a safe and practical method for delivering radio frequency ablation treatment in the hearts of patients with atrial fibrillation, according to a new study in the April 4, 2006, issue of the Journal of the American College of Cardiology.

4 Apr 2006

Three-dimensional ultrasound probes poised to advance minimally invasive surgery

Three-dimensional ultrasound probes built by researchers at Duke's Pratt School of Engineering have imaged the beating hearts of dogs. The engineers said their demonstration showed that the probes could give surgeons a better view during human endoscopic surgeries in which operations are performed through tiny "keyhole" incisions.

4 Apr 2006

Antioxidant therapy will be useful for women with pre-eclampsia

The antioxidant tempol prevents the onset of pre-eclampsia in pregnant mice, a finding that further implicates oxidative stress in the illness, which is widespread among pregnant women.

4 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Vascular endothelial cells (VECs) form the walls of blood vessels and play a critical role in inflammation.

4 Apr 2006

Proteomics yields new drug targets for treating cardiogenic shock

When it comes to cell signaling and bioregulation, it's tough to find a more important molecule than nitric oxide (NO). Dysfunction of NO-mediated signaling is thought to be a culprit in lethal cardiovascular conditions such as angina, and septic, cardiogenic and hemorrhagic shock; it may play a role in many other illnesses as well.

3 Apr 2006

First trial to combine a biologic agent with a conventional chemotherapy agent for the treatment of ovarian cancer

Researchers found the addition of thalidomide to topotecan for the treatment of recurrent ovarian cancer significantly increases the response to therapy and the duration of progression free survival without additional toxicity.

28 Mar 2006

Aspirin therapy offers equal heart-protection to both men and women

Previous studies have suggested that when it comes to using aspirin as a preventative for heart attacks, it is less effective in women than in men.

27 Mar 2006

Trial of paclitaxel with or without bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer

Results from a large, randomised clinical trial for patients with breast cancer show that those who received bevacizumab (Avastin.) in combination with paclitaxel (Taxol.) survived without the disease getting worse for almost twice as long as patients who received paclitaxel alone.

23 Mar 2006

Low-dose aspirin lowers potential for clot-forming blood cells - in both men and women

In what is believed to be the first direct comparison of blood cell testing in both sexes of 81 milligrams of acetyl salicylic acid a day, Hopkins researchers found aspirin therapy prevents the clumping together of these clot-forming cells, called platelets.

23 Mar 2006

Jefferson neurosurgeons use innovative "Wingspan Stent System" to open clogged brain arteries

Neurosurgeons at Thomas Jefferson University Hospital in Philadelphia are the first in the region and among the first in the nation to successfully use a new stent specifically designed to open potentially life-threatening clogged arteries in the brain, preventing a stroke.

22 Mar 2006

Blood Vessels News and Research

Sildenafil improves blood flow after heart attack in an animal model

Losartan can prevent progression of Marfan syndrome

Fat cells surrounding coronary arteries may play a role in development of heart disease

Scientists use corrective gene to block a protein in the kidneys that triggers high blood pressure

Carbon monoxide inhibitor controls traumatic bleeding

Custom-made bladders produced from patients' own cells

First human recipients of laboratory-grown organs

Regular use of COX-2 inhibitors may reduce the risk of breast cancer

Moderate alcohol intake stimulates tumor angiogenesis and expression of vascular endothelial growth factor in a mouse model

Robotic device appears to be more precise than conventional catheter ablation devices for atrial fibrillation

Three-dimensional ultrasound probes poised to advance minimally invasive surgery

Antioxidant therapy will be useful for women with pre-eclampsia

Targeting the inflamed synovium: The quest for specificity

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Proteomics yields new drug targets for treating cardiogenic shock

First trial to combine a biologic agent with a conventional chemotherapy agent for the treatment of ovarian cancer

Aspirin therapy offers equal heart-protection to both men and women

Trial of paclitaxel with or without bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer

Low-dose aspirin lowers potential for clot-forming blood cells - in both men and women

Jefferson neurosurgeons use innovative "Wingspan Stent System" to open clogged brain arteries

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