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FSU researchers link prenatal nicotine exposure to future ADHD

Prenatal exposure to nicotine could manifest as attention deficit hyperactivity disorder in children born a generation later, according to a new study by Florida State University College of Medicine researchers.

28 Feb 2014

Study provides novel insight into the impact of genes on Huntington's disease

A study led by researchers at Boston University School of Medicine provides novel insight into the impact that genes may have on Huntington's disease (HD). The study, published online in PLOS Genetics, identified specific small segments of RNA (called micro RNA or miRNA) encoded in DNA in the human genome that are highly expressed in HD.

27 Feb 2014

Advanced paternal age effects extend to several psychiatric disorders

The effect of advanced paternal age at childbearing on the psychiatric morbidity risk of their children extends to several psychiatric disorders and particularly bipolar disorder, findings from a sibling-comparison study show.

27 Feb 2014

Novel SCLC tumour suppressor gene discovered

Inactivation of the MYC-associated factor X gene, MAX, may play a significant role in the development of small-cell lung cancer, scientists believe.

26 Feb 2014

FDA approves KALYDECO for people with cystic fibrosis

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the U.S. Food and Drug Administration (FDA) approved a supplemental New Drug Application (sNDA) for KALYDECOTM (ivacaftor) for people with cystic fibrosis (CF) ages 6 and older who have one of eight additional mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. KALYDECO was first approved in January 2012 for people with CF ages 6 and older who have at least one copy of the G551D mutation.

26 Feb 2014

Preventive oophorectomy reduces risks of ovarian, breast cancers in women with BRCA mutation

Women who carry a BRCA gene mutation and opt for a preventive oophorectomy, or ovary removal surgery, have a 77 per cent lower risk of death than those who do not, according to a new study led by Women's College Hospital's Amy Finch and Dr. Steven Narod.

26 Feb 2014

Unusual EGFR mutation should influence advanced NSCLC treatment choice

Non-small-cell lung cancer patients with very unusual epidermal growth factor receptor mutations may be more likely to be benefit from first-line chemotherapy than a tyrosine kinase inhibitor, research suggests.

25 Feb 2014

Understanding autism: an interview with Roberto Fernández Galán, PhD, Assistant Professor, Case Western Reserve School of Medicine

Autism does not come in just one flavour. It is a spectrum of disorders that share several features: impaired social interactions; impaired verbal and non-verbal communication; and restricted, repetitive behaviours.

25 Feb 2014

Study: Women with BRCA1 mutations should have preventive ovarian surgery by age 35

The findings of a large international prospective study published in the Journal of Clinical Oncology suggest for the first time that women with BRCA1 mutations should have preventive ovarian surgery (prophylactic oophorectomy) by age 35, as waiting until a later age appears to increase the risk of ovarian cancer before or at the time of the preventive surgery.

25 Feb 2014

Origin of deadly human malaria parasite linked to primates in Africa, not Asia

An international team of scientists has traced the origin of Plasmodium vivax, the second-worst malaria parasite of humans, to Africa, according to a study published this week in Nature Communications.

25 Feb 2014

Researchers find that single genetic mutation causes resistance to DDT and pyrethroids

Researchers from LSTM have found that a single genetic mutation causes resistance to DDT and pyrethroids (an insecticide class used in mosquito nets). With the continuing rise of resistance the research, published in the journal Genome Biology, is key as scientists say that this knowledge could help improve malaria control strategies.

25 Feb 2014

Researchers discover how brain cells change during learning and memories

A new University of British Columbia study identifies an important molecular change that occurs in the brain when we learn and remember.

25 Feb 2014

IIN collaborates with Nanyang Technological University to establish Nanomedicine

Northwestern University's International Institute for Nanotechnology (IIN) is collaborating with Nanyang Technological University (NTU), Singapore, to establish the NTU-Northwestern Institute for Nanomedicine.

24 Feb 2014

Researchers find new drug compound that treats laboratory mice with congenital heart disease

Congenital heart disease is the most common form of birth defect, affecting one out of every 125 babies, according to the National Institutes of Health. Researchers from the University of Missouri recently found success using a drug to treat laboratory mice with one form of congenital heart disease, hypertrophic cardiomyopathy - a weakening of the heart caused by abnormally thick muscle.

23 Feb 2014

Study on Zebrafish neurons could lead to better understanding of birth defects in humans

The zebrafish, a tropical freshwater fish similar to a minnow and native to the southeastern Himalayan region, is well established as a key tool for researchers studying human diseases, including brain disorders.

21 Feb 2014

MATH biomarker with HPV status may provide improved outcomes in HNSCC patients

Evaluating next-generation sequencing (NGS) data and associated clinical records of head and neck squamous cell carcinoma (HNSCC) patients from several institutions, made available through The Cancer Genome Atlas (TCGA), showed that combining Mutant-Allele Tumor Heterogeneity (MATH) as a biomarker with the patient's HPV status provides an effective indicator of improved patient outcome, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

21 Feb 2014

Lung cancer patients with Del19 mutation benefit most from afatinib

Afatinib has been approved in Germany since September 2013 for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer with activating EGF receptor mutations who have not been treated with an EGF receptor tyrosine-kinase inhibitor (EGFR TKI).

20 Feb 2014

Supercomputer dramatically accelerates genome analysis

Although the time and cost of sequencing an entire human genome has plummeted, analyzing the resulting three billion base pairs of genetic information from a single genome can take many months.

20 Feb 2014

Scientists receive 2014 Dan David Prize for exceptional excellence in sciences, arts and humanities

Pulitzer Prize-winning Holocaust historian Prof. Saul Friedlander and artificial intelligence pioneer Prof. Marvin Minsky are among the winners of the 2014 Dan David Prize, which annually bestows three awards of $1 million each.

20 Feb 2014

Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma

The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The research appears February 19 as an advanced online publication in the scientific journal Nature.

20 Feb 2014

Mutation News and Research

FSU researchers link prenatal nicotine exposure to future ADHD

Study provides novel insight into the impact of genes on Huntington's disease

Advanced paternal age effects extend to several psychiatric disorders

Novel SCLC tumour suppressor gene discovered

FDA approves KALYDECO for people with cystic fibrosis

Preventive oophorectomy reduces risks of ovarian, breast cancers in women with BRCA mutation

Unusual EGFR mutation should influence advanced NSCLC treatment choice

Understanding autism: an interview with Roberto Fernández Galán, PhD, Assistant Professor, Case Western Reserve School of Medicine

Study: Women with BRCA1 mutations should have preventive ovarian surgery by age 35

Origin of deadly human malaria parasite linked to primates in Africa, not Asia

Researchers find that single genetic mutation causes resistance to DDT and pyrethroids

Researchers discover how brain cells change during learning and memories

IIN collaborates with Nanyang Technological University to establish Nanomedicine

Researchers find new drug compound that treats laboratory mice with congenital heart disease

Study on Zebrafish neurons could lead to better understanding of birth defects in humans

MATH biomarker with HPV status may provide improved outcomes in HNSCC patients

Lung cancer patients with Del19 mutation benefit most from afatinib

Supercomputer dramatically accelerates genome analysis

Scientists receive 2014 Dan David Prize for exceptional excellence in sciences, arts and humanities

Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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